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What is Magnesium? Magnesium is a trace mineral, a metal. It is the eighth most abundant element in the world, the fourth most abundant in the body, and Magnesium oxide is the second most abundant compound in the earth’s crust. Magnesium is a key component of plant chlorophyll. Why is it Important to Me? Magnesium is used in over 350 enzyme processes in the human body, more than any other trace mineral. Every cell in your body has magnesium inside of it with 99% of your magnesium being inside of cells. Approximately 50% of total body magnesium is found in bone, the other half is found predominantly inside cells of body tissues and organs, and only 1% of magnesium is found in blood (outside of cells). Magnesiumhas a calming effect on the body … the heart, the blood vessels, your muscles, your mind.
It helps maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, and is known to be involved in energy metabolism and protein synthesis Research has shown that if you are diabetic or hypertensive, then you have a magnesium deficiency. Magnesium may one day prove to be the reason we see diabetes, heart disease and high blood pressure in the same people. A diet low in magnesium is associated with a risk of developing these problems. It is possible … but not proven yet … that taking magnesium supplements can prevent, or at the very least assist, these problems. Jerry Nadler is an international expert and division chief of endocrinology and metabolism at the University of Virginia in Charlottesville. He put 16 healthy people on magnesium-deficient diets for a mere three weeks and their cells not only became deficient in magnesium, they became insulin resistant, that is, their body needed more insulin to do its job of putting sugar into cells. He made the remark "You can induce insulin resistance even in people who do not have diabetes. Just deprive them of magnesium."
Calcium and Magnesium Calcium and magnesium work together and against each other. An excess of calcium in your body can upset the balance causing poor absorption of the magnesium, low intracellular levels of magnesium and high levels of cellular calcium leading to hardening of tissues and muscle contractions (spasms). One of the common classes of high blood pressure medications are “calcium blockers” (for example Plendil, Norvasc and Verapamil). This is for a good reason. High levels of calcium inside of the muscles that line arteries cause the muscles to spasm raising blood pressure. We give expensive calcium blockers to stop this. Magnesium is cheaper, safer, and natural and does the same thing, without any nasty side effects. Currently, in the western world, we are eating about four to six times as much calcium as magnesium. The recommended ratio is twice as much calcium as magnesium. Palaeolithic studies show that our bodies developed eating equal amounts of calcium and magnesium – it is important, in today’s world, that we make the appropriate efforts to return to this ratio, for our current and future health. Doesn’t the Doctor Test for Magnesium Deficiency? Most of the time no. It is not a standard addition to the automated metabolic profile like potassium, sodium and chloride. When the doctor does test for magnesium, they usually order serum magnesium. Since the body works hard to maintain a normal blood level of this element, you can lose significant amounts of from inside of your cells yet the blood test will come back ¨normal.¨ In other words, only if your magnesium deficiency is very severe will your doctor diagnose it with a blood test. What are some symptoms of Magnesium deficiency? Magnesium deficiency can cause all of the following but please keep in mind that it is not the only cause of these problems. (Remember, any or all of 350+ processes can go wrong when we are magnesium deficient so the symptoms can be very broad and varied) • Anxiety and panic attacks • Bowel disease • Cystitis • Depression • Insomnia • Headaches • Reynaud’s Syndrome • Tooth decay • Fatigue • Muscle aches and cramps • PMS • Asthma • Kidney stones • Impaired insulin secretion
• Insulin resistance and elevated blood sugars • High blood pressure • Osteoporosis • Atherosclerosis or hardening of the arteries • High triglyceride levels • Mitral valve prolapse • Palpitations, heart irregularities and heart rhythm problems • Phlebitis and blood clots • High hs-CRP, the test for artery inflammation and risk of heart disease • Oxidation … magnesium deficiency has a pro-oxidant effect negating the Antioxidants such as Vitamin C and E that you might be taking.
Increasing your magnesium intake every day may greatly help with these conditions.
How Much Magnesium Do I Need Per Day? The RDA of Magnesium is based on 6-8 mg to kg p/day, and is roughly estimated at:
• 320 milligrams of magnesium daily for women, and • 420 milligrams daily for men.
While these are the current official recommendations, the body needs more when it is under physical or mental stress, when diseased or imbalanced, and when pregnant or breastfeeding. It is therefore recommended that you take 400 to 500 milligrams of magnesium daily, unless otherwise advised by your health care practitioner. This dosage easily meets the recommended daily intake and provides extra for healing, repair and special needs. Depending on your individual condition, and degree of deficiency, supplementation with magnesium may take about six weeks to start to take noticeable effect, so patience is important. Remembering that you didn’t become Magnesium deficient overnight (it’s often months if not years in the making) so give your body time to rebuild its stores before you start to notice the effects. Who may need extra magnesium? Increasing dietary intake of magnesium may not be enough to restore very low magnesium levels to normal, and in such cases a therapeutically viable supplement may be recommended daily for best effect. Magnesium supplementation may be indicated when a specific health problem or condition causes an excessive loss of magnesium or limits magnesium absorption
Some medicines may result in magnesium deficiency, including certain diuretics, antibiotics, and medications used to treat cancer (anti-neoplastic medication) Examples of these medications are:
Diuretics: Lasix, Bumex, Edecrin, and hydrochlorothiazide
Antibiotics: Gentamicin, and Amphotericin
Following an injury or an illness you need more magnesium for tissue repair, as well as during times of excess mental or physical stress (students, athletes, etc.), as during these times the body is under considerable pressure which further exhausts existing magnesium supplies.
Individuals with poorly-controlled diabetes may benefit from magnesium supplements because of increased magnesium loss in urine associated with hyperglycemia [21].
Magnesium supplementation may be indicated for persons with alcoholism. Low blood levels of magnesium occur in 30% to 60% of alcoholics, and in nearly 90% of patients experiencing alcohol withdrawal. Anyone who substitutes alcohol for food will usually have significantly lower magnesium intakes, due to lack of magnesium ingestion through a balanced diet.
Individuals with chronic malabsorptive problems such as Crohn's disease, gluten sensitive enteropathy, regional enteritis, and intestinal surgery may lose magnesium through diarrhea and fat malabsorption. Individuals with these conditions may need supplemental magnesium.
Pregnant and lactating women also require higher daily amounts of Magnesium, as the physical burden of growing a fetus and producing the milk to then feed it, increases a woman’s daily requirement of the mineral. There is also evidence that magnesium levels are further decreased in women who later develop pre-eclampsia. Leg cramps (especially at night) are a sure sign of magnesium deficiency in a pregnant woman.
Individuals with chronically low blood levels of potassium and calcium may have an underlying problem with magnesium deficiency. Magnesium supplements may help correct the potassium and calcium deficiencies.
Older adults are at increased risk for magnesium deficiency. The 1999–2000 and 1988–94 National Health and Nutrition Examination Surveys suggest that older adults have lower dietary intakes of magnesium than younger adults. In addition, magnesium absorption decreases and renal excretion of magnesium increases in older adults. Seniors are also more likely to be taking drugs that interact with magnesium. This combination of factors places older adults at risk for magnesium deficiency. It is very important for older adults to get recommended amounts of dietary magnesium.
Can I get enough magnesium from food? At the turn of the century, people ate more “farm fresh” (less processed) foods and it is estimated that with such a “natural” and “healthy” diet they typically consumed 500 to 1,200 mg of magnesium per day. With the introduction of “fast food” and the highly processed, packaged, flavoured and preserved foods that we see filling our supermarket shelves today, our current average daily consumption is 143 to 266 milligrams of magnesium per day, far below the suggested daily amount of 400-500 mg p/day. It is important to re-introduce more chemical free, natural and organic fresh foods back into the daily diet in order for us to change these stats around and benefit our long-term health. What Foods Contain Magnesium? Green vegetables such as spinach and silver-beet are good sources of magnesium because the center of the chlorophyll molecule (which gives green vegetables their color) contains magnesium.
Magnesium is also contained in wheat germ, wheat bran, wheat grass, spirulina, barley grass, whole grain oats, millet and barley, buckwheat, mature lima beans, navy beans, kidney beans, green beans, soybeans, black-eyed peas, bananas, blackberries, dates, dried figs, mangoes, watermelons, almonds, Brazil nuts, cashews, hazelnuts, shrimp and tuna. Refined grains are generally low in magnesium. When white flour is refined and processed, the magnesium-rich germ and bran are removed. Bread made from whole grain wheat flour provides more magnesium than bread made from white refined flour. Hard water also contains magnesium but most localities prefer soft water without magnesium. Distilled water does not contain any magnesium while mineral water does. Processed foods … sugar, white flour products, most things that come in a box or can have lost their magnesium. Magnesium is not a required element to list on the package nutritional labelling so you don’t know if there is any magnesium in the food or not. In short, eating a variety of whole grains, legumes, and vegetables (especially dark-green, leafy vegetables) every day will help provide recommended intakes of magnesium and maintain normal storage levels of this mineral. Freshly juicing green veg is a great way to boost stores of magnesium naturally, and by increasing dietary intake of magnesium alone, mildly depleted magnesium levels can be restored.
Magnesium Supplementation When considering Magnesium supplementation, as per supplementation of any vitamin or mineral, it is important to remember that the amount of elemental magnesium in a compound and its bioavailability influence the effectiveness of the magnesium supplement. Bioavailability refers to the amount of magnesium in food, medications, and in this case supplements that is absorbed in the intestines and ultimately available for biological activity in your cells and tissues. Enteric coatings (the outer layer of a tablet or capsule that allows it to pass through the stomach and be dissolved in the small intestine) of a magnesium compound can decrease bioavailability, which is why powdered and liquid formulas tend to be much more effective. A great choice is Bioceuticals Ultra muscle-eeze powder tang, sold at most leading health food stores or prescribed upon naturopathic consultation. This is a strong therapeutic grade formula with great bioavailability. Though magnesium supplements have been the most popular strategy to replenish our magnesium reserves, there are also other tried and tested methods alongside oral supplementation and appropriated dietary adjustments. The skin, being our external lung has massive unrecognised absorption potential, whereby using magnesium products topically allows direct entry into the bloodstream, bypassing the digestive system – where issues with absorption and assimilation can sometimes occur, especially in those with pre-existing digestive issues. The following suggestions have proven to be very beneficial for some people wishing to boost their magnesium stores naturally. MagSorb™ is a liquid concentration of magnesium chloride, derived from ancient sea bed deposits. It has a naturally oily texture and is commonly called magnesium oil (although it is not technically a oil). It can be purchased at most leading health food stores or on-line. Epsom Salts (see Epsom salt bathing notes: www.rachelgray.com.au ) Magnesium Sulfate (Epsom salts) can be purchased at most supermarkets and make a great relaxing bath soak. What Interferes with Magnesium absorption? • Boiling vegetables leaches the magnesium out into the liquid. • Cooking in general causes a 40% loss in magnesium. The following cause loss of magnesium in your urine; • Dietary phosphates (found in phosphoric acid) in soft drinks • High salt/sodium diets • High sugar diets • Excess insulin
• Diuretics (caffeine, fluid pills) alcohol and medications (inc. contraceptive pill) • Stress - releases stress hormones that cause magnesium loss • High calcium intake interferes with magnesium absorption If Magnesium is so good why don’t I hear about it more? You can’t patent magnesium. Therefore, there is no incentive for a drug company to spend millions of dollars conducting studies to prove its effectiveness. There are no drug representatives, expensive TV commercials or magazine ads selling magnesium. Unfortunately these days Money, and the profit motive, drive much medical research. No one pays experts to lecture to doctors about magnesium and medical schools don’t teach of its therapeutic value or use. But also, In all fairness, most doctors don’t use magnesium because there have been no large, long term, double blind, placebo controlled studies showing the effectiveness of daily magnesium supplementation in lowering blood sugar, improving insulin resistance, lowering blood pressure, stopping migraine headaches, etc. So to convince doctors will take many years. What are the dangers of Magnesium? Very few… People with diseased kidneys on dialysis should not take magnesium or any other supplement without the express approval of their doctor. Taking too much magnesium, being a muscle relaxant and stimulant of the parasympathetic nervous system, can cause loose stools or diarrhoea as a side effect. If you are a diabetic it might lower your blood sugar too much and if you are hypertensive, it might lower your blood pressure too much … actually the effects we want, so you can start to reduce your dependency on medications. In Summary… Magnesium is one of the most important minerals in our body. Without it, over 350 different enzyme processes can go wrong. It is difficult to measure in the blood, poorly appreciated by physicians and may be the underlying cause of a large number of diseases, including migraine headaches, anxiety and panic attacks, osteoporosis, heart disease, high cholesterol, diabetes, blood clots and hypertension. If you are not eating enough magnesium or it is being poorly absorbed, you will gradually become more and more deficient as the years go on … and no one will diagnose you! Increasing your daily consumption through fresh foods, and or taking a daily magnesium supplement is smart, cheap, safe and good for you now, and long-term.
International Journal of Pharmaceutical Sciences INT.J.PH.SCI.,SEP-DEC, 2010;2(3):680-686 ISSN 0975-4725 Original Research Manuscript Date of Submission: 29-06-2010 Date of Acceptance: 20-09-2010 Evaluation of iridoid glycosides from leave of Barleria Prionitis as an Anti-diarrhoeal Activity: an Ethnopharmacological study Sunil K. Jaiswal3*, Mukesh K
SUMMARY OF PRODUCT CHARACTERISTICS ▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See section 4.8 for how to report adverse reactions. 1. NAME OF THE MEDICINAL PRODUCT Pixuvri 29 mg powder for concentrate for solution