S-table+3 (8-17-07).xls

Supplementary Table 2: Genes upregulated by the cAMP-signaling pathway during normal budding growth
WT/ pde2/ pde2/
Grouping
ORF6. ORF19. cap1 cap1
Function
O-acetylhomoserine O-acetylserine sulfhydrylase; involved in sulfur amino acid biosynthesis; immunogenic; Hog1p; biofilm; Predicted ORF from Assembly 19; Gcn4p-regulatedProtein abundance is affected by URA3 expression in the CAI-4 strain background; alkaline upregulated; Gcn4p-regulatedProtein described as aspartate aminotransferase; soluble protein in hyphae; alkaline upregulated; amphotericin B repressed Malic enzyme, mitochondrial protein; transcription regulated by Mig1p and Tup1p; shows colony morphology-related gene Predicted ORF from Assembly 19; Gcn4p-regulated Large subunit of heterodimeric alpha-aminoadipate reductase; enzyme of lysine biosynthesis; contains predicted binding sites for AMP and alpha-aminoadipate; feedback inhibited by lysine or Putative NAD-specific glutamate dehydrogenase; fungal-specific (no human or murine homolog); transcription is regulated by Nrg1p, Mig1p, Tup1p, and Gcn4pSimilar to an aldose 1-epimerase-related protein; antigenic during murine systemic infectionSimilar to an aldose 1-epimerase-related protein; antigenic during Protein described as a putative precursor of a hypha surface antigen; putative GPI-anchor; induced by ciclopirox olamine, ketoconazole, or by Rim101p at pH 8; regulated during planktonic growth; induced during cell wall regeneration GPI-anchored cell wall protein; has CRoW motif; not required for filamentous growth; expression is regulated by Rfg1p, Rim101p; repressed by Sfu1p, Hog1p, Tup1p; induced by serum, iron, alkaline pH, ketoconazole, or ciclopirox olamine Major cell-surface ferric reductase under low-iron conditions; 7 transmembrane regions and a secretion signal predicted; repressed by Tup1p, Rim101p, Ssn6p, Hog1p, caspofungin; ciclopirox olamine induced; not required for filamentous growth Putative GPI-anchored protein that localizes to the cell wall; transcription is decreased upon yeast-hypha switch; transcriptionally regulated by iron; expression greater in high iron Surface antigen on elongating hyphae and buds; no obvious hypha defects in mutant; strain variation in number of repeat domains; upregulated in filaments; alkaline upregulated by Rim101p; 13.33 ciclopirox induced; Efg1p- and Cph1p-regulated Predicted ORF from Assembly 19; flucytosine inducedPredicted ORF from Assembly 19; ketoconazole-induced; Ergosterol Biosynthesis and Lipid Metabolism ERG251 (XJP2) Ergosterol Biosynthesis and Lipid Metabolism Predicted ORF in Assemblies 19 and 20Protein similar to S. cerevisiae Eht1p; transcription is induced in Ergosterol Biosynthesis and Lipid Metabolism response to alpha pheromone in Spider medium Protein similar to pyruvate decarboxylase; antigenic; at cell surface of hypha, but not yeast-form cells; soluble in hyphae; regulated by Gcn4p, Efg1p, Efh1p; fluconazole-induced; repressed upon amino acid starvation; biofilm-induced Putative alcohol dehydrogenase; soluble protein in hyphae; fungal-specific (no human or murine homolog); expression is regulated upon white-opaque switching; regulated by Ssn6pPutative pyruvate decarboxylase; fungal-specific (no human or Putative pyruvate carboxylase, binds to biotin cofactor; gene is up-regulated in a mutant lacking the Ssk1p response regulator protein, upon benomyl treatment, or in an azole-resistant strain Putative bHLH (basic region, helix-loop-helix) transcription factor; hypha regulated via Cph1p, Cyr1p; flucytosine, Hog1p induced; amphotericin B, caspofungin repressed; downregulated in azole- Protein described as hexokinase II; antigenic in human; downregulated in the presence of human neutrophils; regulated by Efg1p; fluconazole-induced; shows colony morphology-related Alpha subunit of phosphofructokinase (PFK), which is Pfk1p, Pfk2p heteromultimer; PFK is activated by fructose 2,6-bisphosphate or AMP, inhibited by ATP; activity reduced on hypha induction; phagocytosis-downregulated; fluconazole-induced Protein described as phosphoglycerate mutase; enzyme of glycolysis; antigenic during murine, human infection; biofilm-, fluconazole-, or amino acid starvation (3-aminotriazole treatment) Putative ortholog of S. cerevisiae Tpi1p, which is triose-phosphate isomerase involved in glycolysis and gluconeogenesis; antigenic in mouse or human; transposon mutation affects filamentous growth; Predicted ORF in Assemblies 19 and 20Predicted ORF in Assemblies 19 and 20; possibly spurious ORF Predicted ORF from Assembly 19; removed from Assembly 20 Predicted ORF in Assemblies 19 and 20Transcription is positively regulated by Sfu1p; possibly spurious ORF (Annotation Working Group prediction)Predicted ORF from Assembly 19; merged with orf19.3117 in Predicted ORF from Assembly 19; removed from Assembly 20 Inositol-1-phosphate synthase; enzyme of inositol biosynthesis; antigenic in human; repressed by farnesol (in biofilm) or caspofungin; regulated during planktonic growth; upstream inositol/choline regulatory element; glycosylation predicted Iron utilization protein; similar to an S. cerevisiae oxidoreductase, Ynr060wp; regulated by Sfu1p, Nrg1p, Tup1p; alkaline (via Rim101p, low iron, fluphenazine, ciclopirox olamine, flucytosine, induced; caspofungin, amphotericin B repressed Similar to GTPase regulators; transcriptionally regulated by iron; expression greater in low iron; possibly spurious ORF (Annotation Similar to multicopper ferroxidase; transcriptionally regulated by iron; expression greater in low iron; transcription is negatively regulated by Sfu1p; merged with orf19.4215 in Assembly 20 Protein similar to ferric reductases; transcription is positively regulated by Rim101p; expression greater in low iron; fluconazole-downregulated; ciclopirox olamine induced; colony morphology- Protein described as a similar to F1 beta subunit of F1F0 ATPase complex; antigenic in human; transcription upregulated in response to ciclopirox olamine; flucytosine induced; caspofungin repressed; macrophage/pseudohypha-induced Protein not essential for viability; similar to S. cerevisiae Aah1p, which is an adenine deaminase involved in purine salvage and nitrogen catabolism; shows colony morphology-related gene regulation by Ssn6p; Hog1p-, biofilm-induced Similar to oxidoreductases and to S. cerevisiae Yjr096wp; transcription is negatively regulated by Sfu1p; increased transcription is observed upon benomyl treatment; decreased expression observed in an ssr1 homozygous null mutant Predicted ORF in Assemblies 19 and 20Predicted ORF from Assembly 19; transcription is regulated by Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum Protein described as an aminopeptidase; transcription is positively regulated by Sfu1p; transcription is repressed in response to alpha pheromone in Spider mediumPredicted ORF from Assembly 19; soluble protein in hyphae; Putative gypsy-like reverse transcriptase; transcription is downregulated in response to treatment with ciclopirox olamine; 3,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hypha switch; macrophage interaction Inositol phosphoryl transferase, involved in sphingolipid biosynthesis; catalyzes the synthesis of the most abundant sphingolipid, mannose-(inositol-P)2-ceramide, M(IP)2C, from MIPC; required for wild-type membrane localization of Cdr1p Protein described as 4-nitrophenyl phosphatase; hypha downregulated; induced in core stress response; induced by heavy Copper- and zinc-containing superoxide dismutase, expression is regulated during white-opaque switching; ciclopirox olamine induced; caspofungin repressed; member of a gene family that includes SOD1, SOD4, SOD5, and SOD6Predicted ORF in Assemblies 19 and 20; induced by nitric oxide in Protein of TSA/alkyl hydroperoxide peroxidase C (AhPC) family; similar to thiol-dependent peroxidases, roles in oxidative stress signaling; immunogenic; on hypha surface, nucleus; yeast-form nucleus, cytoplasm; neutrophil, peroxide induced D-Arabinono-1,4-lactone oxidase, involved in biosynthesis of D-erythroascorbic acid, which has a protective role against oxidative damage; required for full virulence in a mouse model of systemic Similar to thioredoxin; increased transcription is observed upon benomyl treatment; flucytosine induced; amphotericin B repressed; caspofungin repressed; peroxide-induced; upregulated SUMO, small ubiquitin-like protein; Smt3p-conjugated proteins localize to septation site and mother side of bud neck; C. albicans septins appear not to be Smt3p-modified, in contrast to S. cerevisiae septins; similar to S. cerevisiae Smt3p Protein described as beta subunit of succinate-CoA ligase; transcription regulated by Mig1p and Tup1p; transcriptionally regulated by iron; expression greater in high iron; merged with orf19.1860 in Assembly 20Protein described as isocitrate dehydrogenase; transcriptionally induced by interaction with macrophage; alkaline upregulated Putative transcription factor; zinc finger; similar to S. cerevisiae Crz1p; homozygous crz1, not crz2, null mutation suppresses fluconazole resistance of homozygous cka2 null (defective in CK2 Protein similar to S. cerevisiae Pob3p, which is involved in chromatin assembly and disassembly; transposon mutation affects Predicted ORF from Assembly 19; caspofungin repressed Putative transporter; slightly similar to the Sit1p siderophore transporter; Gcn4p-regulated; fungal-specific (no human or murine homolog)Putative low-affinity phosphate transporter; fungal-specific (no Putative potassium transporter; similar to Schwanniomyces occidentalis Hak1p; amphotericin B induced; transcriptionally induced upon phagocytosis by macrophagePutative sperimidine transporter; fungal-specific (no human or Putative glucose transporter, major facilitator superfamily; glucose-, fluconazole-, Snf3p-induced, expressed at high glucose; upregulated in biofilm; C. albicans glucose transporter family comprises 20 members; 12 TM regions predicted Protein not essential for viability; similar to S. cerevisiae Smf1p, which is a manganese transporter; Gcn4p-regulated; alkaline Oligopeptide transporter; transports 3-to-5-residue peptides; alleles are distinct, one has intron; not ABC or PTR type transporter; suppresses S. cerevisiae ptr2-2 mutant defects; induced by BSA or peptides; Stp3p, Hog1p regulated Predicted ORF in Assemblies 19 and 20; Gcn4p-regulated; flucytosine induced; ketoconazole-repressed; oxidative stress- Protein described as predicted zinc transporter; ciclopirox olamine, fluconazole, or alkaline downregulated; transcriptionally induced by interaction with macrophage; amphotericin B inducedAlkaline downregulated; amphotericin B induced; shows colony morphology-related gene regulation by Ssn6pPutative general amino acid permease; Plc1p-regulated; Gcn4p- regulated; fungal-specific (no human or murine homolog) Putative oligopeptide transporter; regulated by Stp2p and Stp3p; transcriptionally induced upon phagocytosis by macrophage; downregulated by Rim101p at pH 8Predicted ORF in Assemblies 19 and 20; regulated by Tsa1p, Transcriptionally regulated by iron or by yeast-hypha switch; expression greater in high iron, decreased upon yeast-hypha switch; downregulation correlates with clinical development of fluconazole resistance; Ras1p-regulatedPredicted ORF in Assemblies 19 and 20; ciclopirox olamine induced; regulated by Ssn6p; induced by nitric oxide in yhb1 Predicted ORF in Assemblies 19 and 20; decreased expression observed in an ssr1 homozygous null mutant Predicted ORF in Assemblies 19 and 20; ketoconazole-repressed Predicted membrane protein; similar to S. cerevisiae Ynr018wp Protein not essential for viability; similar to S. cerevisiae Ecm21p (may have cell wall role); alkaline upregulated by Rim101p; fluconazole induced; caspofungin repressed; downregulated in azole-resistant strain overexpressing MDR1 Putative 3-phosphoserine phosphatase; fungal-specific (no human or murine homolog); increased transcription is observed upon benomyl treatment or in an azole-resistant strain that Predicted ORF in Assemblies 19 and 20; downregulation correlates with clinical development of fluconazole resistance Protein similar to S. cerevisiae Sha3p, which is a serine/threonine kinase involved in glucose transport; transposon mutation affects filamentous growth; fluconazole-induced; ketoconazole-repressed; induced in response to alpha pheromoneProtein described as having a role in Ty3 transposition; decreased expression in hyphae compared to yeast-form cells Putative cell wall protein; transcription is negatively regulated by Rim101p, Efg1p, Ssn6p; alkaline downregulated; predicted signal Predicted ORF in Assemblies 19 and 20; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2Predicted ORF in Assemblies 19 and 20; fluconazole-induced;

Source: http://www.candidagenome.org/download/systematic_results/Bahn_2007/S_Table_3.pdf

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udo ruhrenwassenberger str. 9852525heinsberg organisierte kriminalität in der euregio maas-rhein im februar dieses jahres wurde ich auf betreiben meines vaters, ernst von der ruhren und meines onkels, kriminalhauptkommissar ullrich gütte, von der heinsberger polizei gewaltsam in die psychiatrie der gangelter einrichtungen verbracht und dort zu einer medikation gezwungen, die mein herz, das

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Iranian J Parasitol: Vol. 3, No. 2, 2008, pp. 38-42 Original Article In Vitro Effects of Metronidazole and Albendazole on Giardia lamblia Isolated from Iranian Patients F Mohamadnezhad, * F Ghaffarifar, A Dalimi Dept. of Parasitology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran (Received 28 Dec 2007; Accepted 08 Mar 2008) Abstrac

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