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Research Outputs
Publications
The WADDP has over 100 research publications in top-ranking internationally ISI-recognizedpeer-reviewed scientific journals. Below is a representative list of original research articles and criticalreview papers published since 2010. (Access to publications prior to 2010 is available on request) 1. In vitro evaluation of the physicochemical effects of drug-loaded carbon nanotubes on toxicity, Nyaradzo Chigumbu, Sunny Iyuke, Viness Pillay and Sehliselo Ndlovu, Journal of Nanomedicineand Nanotechnology, 3(4), 1-7, 2012. 2. Surface-engineered nanoliposomes by chelating ligands for modulating the neurotoxicity associated with ?-amyloid aggregates of Alzheimer's disease, Steven Mufamadi, Yahya E.
Choonara, Pradeep Kumar, Girish Modi, Dinesh Naidoo, Valence Ndesendo, Lisa C. du Toit,Leith C.R. Meyer, Sunny E. Iyuke and Viness Pillay, Pharmaceutical Research, Published Online,DOI: 10.1007/s11095-012-0770-0, 2012.
3. Composite polylactic-methacrylic acid copolymer nanoparticles for the delivery of methotrexate, Bongani Sibeko, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Riaz A. Khan,Valence M.K. Ndesendo, Pradeep Kumar, Sunny E. Iyuke and Viness Pillay, Journal of DrugDelivery, Volume 2012, 1-18, 2012.
4. A novel pH-dependant and double crosslinked polymethacrylate-based polysphere matrix for enteric delivery of isoniazid, Shivaan Cooppan, Viness Pillay, Yahya E. Choonara, Lisa C. duToit, Valence M.K. Ndesendo and Pradeep Kumar, Pharmaceutical Development andTechnology, Published Online, DOI:10.3109/10837450.2012.685654, 2012.
5. Orally administered therapeutic peptide delivery: Enhanced absorption through the small intestine using permeation enhancers, Viness Pillay, Angus Hibbins, Yahya E. Choonara, Lisa C. du Toit,Pradeep Kumar and Valence M.K. Ndesendo, International Journal of Peptide Research andTherapeutics, Published Online, DOI: 10.1007/s10989-012-9299-7, 2012.
6. Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test-tube to in vivo success, Viness Pillay, Felix Mashingaidze, Yahya E. Choonara, Lisa C. duToit, Valence Ndesendo and Pradeep Kumar, Journal of Pharmaceutical Sciences,101:1950–1968, 2012.
7. Crosslinked electrospun PVA nanofibrous membranes: Elucidation of their physicochemical, physicomechanical and molecular disposition, Rubina Shaikh, Viness Pillay, Yahya E. Choonara,Lisa C. du Toit, Valence M.K. Ndesendo and Pradeep Kumar, Biofabrication, 4(2):025002, 2012.
8. Micromechanical and physical stability analysis of an irradiated poly(lactic-co-glycolic acid) donut-shaped minitablet device for intraocular implantation, Yahya E. Choonara, Viness Pillay,Michael P. Danckwerts, Trevor R. Carmichael, Lisa C. du Toit and Riaz A. Khan, PharmaceuticalDevelopment and Technology, Published Online, DOI: 10.3109/10837450.2011.619541, 2012.
9. Optimization of a polymer composite employing molecular mechanic simulations and artificial neural networks for a novel intravaginal bioadhesive drug delivery device, Valence M.K.
Ndesendo, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Eckhart Buchmann, Leith C.R.
Meyer and Riaz A. Khan, Pharmaceutical Development and Technology, 17(4), 407-420, 2012. 10. Optimization of a dual mechanism gastrofloatable and gastroadhesive delivery system for narrow absorption window drugs, Caragh S. Murphy, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit,Valence M.K. Ndesendo, Nthato Chirwa and Pradeep Kumar, AAPS PharmSciTech, 13(1):1-15,2012.
11. The application of a crosslinked pectin-based wafer system for gradual buccal drug delivery, Rubina P. Shaikh, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K. Ndesendo,Pradeep Kumar and Riaz A. Khan, Journal of Biomedical Materials Research Part B: AppliedBiomaterials, 100(4):1029-43, 2012.
12. Advanced preformulation investigations for the development of a lead intravaginal bioadhesive polymeric device, Valence M.K. Ndesendo, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit,Eckhart Buchmann, Pradeep Kumar, Riaz A. Khan and Leith C.R. Meyer, Drug Development andIndustrial Pharmacy, 38(3):271-93, 2012.
13. Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery, Kovanya Moodley, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K.
Ndesendo, Shivaan Cooppan, Priya Bawa and Pradeep Kumar, International Journal ofMolecular Sciences, 13, 18-43, 2012.
14. Fabrication, modeling and characterization of multi-crosslinked methacrylate copolymeric nanoparticles for oral drug delivery, Ndidi C. Ngwuluka, Viness Pillay, Yahya E. Choonara, GirishModi, Dinesh Naidoo, Lisa C. du Toit, Pradeep Kumar, Valence M.K. Ndesendo and Riaz A.
Khan, International Journal of Molecular Sciences, International Journal of Molecular Sciences,12(9), 6194-6225, 2011.
15. Recent advances in the design of drug-loaded polymeric implants for the enhanced treatment of solid tumors, Ameena Wadee, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, ClementPenny, Valence M.K. Ndesendo and Caragh S. Murphy, Expert Opinion on Drug Delivery, 8(10),1323-1340, 2011.
16. Invited Paper Focus Issue on Liposomes: A review on composite liposomal technologies for specialized drug delivery, Maluta S. Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. Du ToitGirish Modi Dinesh Naidoo and Valence M.K. Ndesendo, Journal of Drug Delivery, volume(2011), 1-19, 2011. Accreditation: ISI; IF: None 17. Polymeric emulsion and crosslink-mediated synthesis of super-stable nanoparticles as sustained-release anti-tuberculosis drug carriers, Yahya E. Choonara, Viness Pillay, ValenceM.K. Ndesendo, Lisa C. du Toit, Riaz A. Khan, Caragh S. Murphy and Debbie-Leigh Jarvis,Colloids And Surfaces B: Biointerfaces, 87, 243-254, 2011.
18. Polymeric Intracorporeal Devices for the Management of Neurological Disorders, Viness Pillay, Thiresen Govender, Yahya E. Choonara, Valence M.K. Ndesendo, Lisa C. du Toit, Girish Modiand Dinesh Naidoo, Polymers Research Journal, 4(2-3), Nova Science Publishers Inc.,Hauppauge, NY, USA, 2011. 19. Diverse approaches for the enhancement of oral drug bioavailability, Pius Fasinu, Viness Pillay, Valence Ndesendo, Lisa du Toit, Yahya Choonara, Biopharmaceutics and Drug Disposition, 32,185–209, 2011.
20. A composite polyelectrolytic matrix for controlled drug delivery, Priya Bawa, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K. Ndesendo and Pradeep Kumar, AAPSPharmSciTech, Published Online, 12(1), 227-238, 2011.
21. In vivo evaluation of a biodegradable donut-shaped minitablet for prolonged posterior segment drug delivery in the rabbit eye model, Yahya E. Choonara, Viness Pillay, Michael P. Danckwerts,Trevor Carmichael, Leith Meyer, Lisa C. du Toit, Simon Naylor and Carla Wanblad, Journal ofPharmaceutical Sciences, 100(5), 1819-1832, 2011. Accreditation: ISI; IF: 2.906 22. In vivo evaluation of the release of zidovudine and polystyrene sulfonate from a dual intravaginal bioadhesive polymeric device in the pig model, Valence M. K. Ndesendo, Viness Pillay, Yahya E.
Choonara, Lisa C. du Toit, Leith C.R. Meyer, Eckhart Buchmann, Riaz A. Khan and PradeepKumar, Journal of Pharmaceutical Sciences, 100(4), 1416-1435, 2011. Accreditation: ISI; IF:2.906 23. Investigating the effect of polymeric approaches on circulation time and physical properties of nanobubbles, Lisa C. du Toit, Thirumala Govender, Viness Pillay, Yahya E. Choonara andTetsuya Kodama, Pharmaceutical Research, 28(3), 494-504, 2011. Accreditation: ISI; IF: 3.933 24. Invited Paper for Special Issue on Neuroprotective Strategies: In silico theoretical drug modeling for Alzheimer’s disease: The nicotine – curcumin paradigm in neuro-protection and neuro-therapy, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi,Dinesh Naidoo, International Journal of Molecular Sciences, 12, 694-724, 2011.
25. Invited Paper: Polyvinyl alcohol-polyaniline based electro-conductive hydrogels for controlled stimuli-responsive liberation of indomethacin, Tong-Sheng Tsai, Viness Pillay, Yahya E.
Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo and Pradeep Kumar, Polymers, 3,150-172, 2011. Accreditation: ISI; IF: None 26. Invited paper: Ocular drug delivery – A look toward nanobioadhesives, Lisa C. du Toit, Viness Pillay and Yahya E. Choonara, Expert Opinion on Drug Delivery, 8(1), 71-94, 2011. Accreditation:ISI; IF: 3.345 27. Invited Paper: Self-assembling peptides: Implications for patenting in drug delivery and tissue engineering, Pradeep Kumar, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, RecentPatents on Drug Delivery and Formulation, 5(1), 24-51, 2011. Accreditation: ISI; IF: None 28. The influence of polyamide 6,10 synthesis variables on the physicochemical characteristics and drug release kinetics from a monolithic tablet matrix, Oluwatoyin Kolawole, Viness Pillay, YahyaE. Choonara, Lisa C. du Toit and Valence M.K. Ndesendo, Pharmaceutical Development andTechnology, 15(6), 595-612, 2010. Accreditation: ISI; IF: 0.895 29. An intracranial neurocompatible nanocomposite polymeric device for the chronic management of AIDS Dementia Complex, Riaz A. Khan, Sheri-Lee Harilall, Viness Pillay, Yahya E. Choonara,Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Sunny E. Iyuke, Nanotechnology 2010: Bio Sensors,Instruments, Medical, Environment and Energy-Technical Proceedings of the 2010 NSTINanotechnology Conference and Expo, NSTI-Nanotech 2010, 3, 361-363, 2010. Accreditation:ISBN 978-1-4398-3415-2; IF: None 30. Triple-layered solid matrix tablet configurations for constant multiple drug delivery, Kovanya Moddley, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, Journal of Pharmacy andPharmacology, 62(10), 1313-1314, 2010. Accreditation: ISI; IF: 1.742 31. Elucidation of the potential of starch-based multiparticulates for use as a platform in novel drug delivery systems, Yusuf Dawood, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, Journalof Pharmacy and Pharmacology, 62(10), 1429-1430, 2010. Accreditation: ISI; IF: 1.742 32. A polyamide-based membranous device for specialized drug delivery, Thiresen Govender, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and Dinesh Naidoo, Journal ofPharmacy and Pharmacology, 62(10), 1243-1244, 2010. Accreditation: ISI; IF: 1.742 33. Biological rhythms and chronopharmaceuticals: A timely review of state-of-the-art chronopharmaceuticals synchronized with biological rhythms, Seshni Sewlall, Viness Pillay,Yahya E. Choonara Valence M.K. Ndesendo and Lisa C. du Toit, Current Drug Delivery, 7(5),370-388, 2010. Accreditation: ISSN 1567-2018; IF: None 34. Rationalising fixed dose combinations for tuberculosis and acquired immunodeficiency syndrome therapy, Shivaan Cooppan, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit and Valence M.K.
Ndesendo, International Journal of Biotechnology, 11(3/4), 284-304, 2010. Accreditation: ISSN:0963-6048; IF: None 35. Investigation of the physicochemical and physicomechanical properties of a novel intravaginal bioadhesive polymeric device in the pig model, Valence M.K. Ndesendo, Viness Pillay, Yahya E.
Choonara, Leith C.R. Meyer, Eckhart Buchmann, Lisa C. du Toit, Riaz A. Khan and Uwe Rosin,AAPS PharmSciTech, 11(2), 793-808, 2010. Accreditation: ISI; IF: 1.190 36. Encapsulation of essential oils within a polymeric liposomal formulation for enhancement of antimicrobial efficacy, Ashleigh Parry, Sandy van Vuuren, Lisa C. du Toit, Viness Pillay andYahya E. Choonara, Natural Product Communications, 5(9), 1401-1408, 2010. Accreditation: ISI;IF: 0.745 37. A review of multi-responsive membranous systems for rate-modulated drug delivery, Rubina P.
Shaikh, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence MK Ndesendo, Priya Bawa,Shivaan Cooppan, AAPS PharmSciTech, 11, 441-459, 2010. Accreditation: ISI; IF: 1.190 38. Construction and in vitro characterization of an optimized porosity-enabled amalgamated matrix for sustained transbuccal drug delivery, Oluwatoyin Adeleke, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, International Journal of Pharmaceutics, 391, 79-89, 2010. Accreditation: ISI;IF: 2.962 39. A review of implantable intravitreal drug delivery technologies for the treatment of posterior chamber eye diseases, Yahya E. Choonara, Viness Pillay, Michael P. Danckwerts, Trevor R.
Carmichael and Lisa C. du Toit, Journal of Pharmaceutical Sciences, 99, 2219-2239, 2010.
Accreditation: ISI; IF: 2.906 40. Invited Paper: Nano-microbicides: Challenges in drug delivery, patient ethics and intellectual property in the war against HIV/AIDS, Lisa C. du Toit, Viness Pillay and Yahya E. Choonara,Advanced Drug Delivery Reviews, 62, 532-546, 2010. Accreditation: ISI; IF: 11.957; Citations: 1 41. Invited Paper: Advances in the treatment of neurodegenerative disorders employing nanotechnology, Girish Modi, Viness Pillay and Yahya E. Choonara, Annals of the New YorkAcademy of Sciences, 1184, 154-172, 2010. Accreditation: ISI; IF: 2.670 42. Levodopa delivery systems: Advancements in delivery of the gold standard, Ndidi Ngwuluka, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence MK Ndesendo, Expert Opinion onDrug Delivery, 7(2), 203-224, 2010. Accreditation: ISI; IF: 3.345 43. A mathematical approach for the simultaneous in vitro spectrophotometric analysis of rifampicin and isoniazid from modified release anti-TB drug delivery systems, Lisa C. du Toit, Viness Pillayand Yahya E. Choonara, Current Drug Delivery, 7, 5-12, 2010. Accreditation: ISSN 1567-2018;IF: None For a reprint of any of the publications above kindly send your emailed requests to Prof. Viness Pillay Conference and Seminar Papers Presented
The WADDP has made over 300 oral and poster presentations at recognized international and localpeer-reviewed conferences. Below is a representative list of original research findings that werepresented since 2010. 1. Exploration of a Composite Nano-Medical Device for the Delivery of Neuroprotectant-Nanocarriers into Targeted Neuronal Cells of Alzheimer’s disease. Maluta S.
Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar,Valence M.K. Ndesendo, Leith C.R Meyer, Sunny E. Iyuke, Viness Pillay. 16th Congress of theEuropean Federation of Neurological Societies (EFNS), Ageing and dementia, Stockholm,Sweden, Europe, September 08 - 11, 2012.
2. Design, Biomolecular Modeling and Evaluation of Surface-Engineered Nanoliposomes for the Management of Alzheimer’s disease. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit,Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R Meyer, SunnyE. Iyuke, Viness Pillay. 16th Congress of the European Federation of Neurological Societies(EFNS), Neurotoxicology/Occupational Neurology, Stockholm, Sweden, Europe, September 08 -11, 2012.
3. Physicomechanical Transitions of an Implantable Nano-Enabled Biorobotic Intracranial Device for Alzheimers Disease Management for Validation of In Vivo Behaviour in a Simulated Brain
Environment. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh
Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R Meyer, Sunny E. Iyuke, Viness
Pillay. 16th Congress of the European Federation of Neurological Societies (EFNS), Ageing and
dementia, Stockholm, Sweden, Europe, September 08-11, 2012.
4. Bio-Architecture of an Implantable Nano-Biorobotic Intracranial Device for Optimized CNS Drug Delivery. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo,Pradeep Kumar, Valence M.K. Ndesendo, Sunny E. Iyuke, Viness Pillay. Wits Faculty of HealthSciences Research Day & Postgraduate Expo 2012. Wits Medical School, Parktown, JHB, SouthAfrican. September 19, 2012.
5. Design, Development and Optimisation of a Novel Neurotherapeutic Intracranial Implantable Composite Device Thiresen Govender, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E.
Choonara and Lisa C. du Toit Presented at the British and Irish Group for the Study ofPersonality Disorders (BIGSPD) Conference, Manchester, United Kingdom, March 2012.
(POSTER) 6. Novel Approaches to Personality Disorder Treatment: Design of Dual-Acting Nanoparticles for the Enhanced Neurotherapy of Borderline Personality Disorder Thiresen Govender, NabeelaBhabha, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara and Lisa C. du ToitPresented at the British and Irish Group for the Study of Personality Disorders (BIGSPD)Conference, Manchester, United Kingdom, March 2012. (POSTER) 7. Advances in Neurotherapeutics: Intracranial Implantation of a Novel Optimised Polymeric Composite in the New Zealand White Rabbit Cadaver Thiresen Govender, Viness Pillay, GirishModi, Dinesh Naidoo, Yahya E. Choonara, Lisa C. du Toit and Leith Meyer Presented at theBritish and Irish Group for the Study of Personality Disorders (BIGSPD) Conference, Manchester,United Kingdom, March 2012.
8. Fabrication and Evaluation of Camptothecin-loaded Nano-liposomes for the Targeted Treatment of Ovarian Cancer, Derusha Frank, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, ClementPenny, Viness Pillay, NanoBio 2012 Conference, Villa Ponti, Varese, Lombardy, Italy, 18-20 June2012.
9. Formulation, optimization and characterization of mucin-pectin-polyethylene glycol microspheres for intravaginal anti-HIV-1 drug delivery, Felix Mashingaidze, Viness Pillay, Yahya E. Choonara,Lisa C. du Toit, Vinesh Maharaj, Eckhart Buchmann, Valence M.K. Ndesendo and PradeepKumar, PharmSci 2012 Conference: The Science of Medicines, East Midlands ConferenceCentre, Nottingham, United Kingdom, 12 - 14 September 2012.
10. Polyphenol-Flavonol synergistic paradigm for neural repair: combinatorial computational modeling approach for post-traumatic ?-calpain inactivation, Pradeep Kumar, Viness Pillay,Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, 7th World Congress forNeuroRehabilitation Congress (WCNR): Innovations in NeuroRehabilitation, MelbourneConvention & Exhibition Centre, Melbourne, Victoria, Australia, 16–19 May 2012. 11. Image processing and analysis to investigate the morphological design parameters for the fabrication of nanofibrous and macroporous polymeric scaffolds, Pradeep Kumar, Viness Pillay,Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, 36th Annual South AfricanNumerical and Applied Mathematics Conference, Professional Development Hub, University ofthe Witwatersrand, Johannesburg, Gauteng, South Africa, 02-04 April, 2012.
12. In silico theoretical molecular modeling for Alzheimer’s disease: The nicotine-curcumin paradigm in neuroprotection and neurotherapy, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, GirishModi, Dinesh Naidoo and Lisa C. du Toit, 19th Biennial Meeting of the International Society forDevelopmental Neuroscience - ISDN2012: Neurodevelopment and Neurological diseases, TataInstitute of Fundamental Research, Mumbai, Maharashtra, India, 11-14 January, 2012.
13. Engineering multifunctional nanoconstructs for spinal cord injury intervention: Nanomicelles-enclatherated nanofibriller implants mimicking the nanophysicomechanicalproperties of spinal cord, Pradeep Kumar, Dinesh Naidoo, Girish Modi, Yahya E. Choonara,Viness Pillay, 22nd Biennial Congress of the Society of Neurosurgeons of South Africa, LordCharles Hotel, Western Cape, South Africa, 4-6 October, 2012. [Abstract accepted for oralpresentation] 14. Multifunctional Nanoconstructs- Enclatherated Nanoporous Implants for Spinal Cord injury Intervention: Mimicking the Nanophysicomechanical Properties of Spinal Cord, Pradeep Kumar,Yahya E. Choonara, Girish Modi, Dinesh Naidoo, Viness Pillay, 10th Biennial Southern AfricanSpinal Cord Association Congress, The Pavilion Conference Centre, V & A Waterfront, CapeTown, South Africa, 22-24 November, 2012.
15. In Vivo Verification of the Bioresponsive Potential of an Intelligent Intraocular Implant, Lisa C. Du Toit, Viness Pillay, Thirumala Govender, Trevor Carmichael and Yahya E. Choonara, Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2012, Fort LauderdaleFlorida, USA, 6-10 May 2012.
16. Effect of polymer functionalization and crosslinking on the design of novel spinomimetic cryosponges: A mechanotransduction approach for enhanced neuronal anchoring, PradeepKumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and D. Naidoo, 4thInternational Conference on the Mechanics of Biomaterials and Tissues, Marriott Waikola BeachResort and Spa, Hawai’i, USA, 11-14 December 2011.
17. Robust design of biodegradable block-copoly(ester-ether)s and multifunctional nanoconstructs for spinal cord injury intervention: Cellular uptake and nano-neuro-sealing of disrupted neuronalmembranes, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi andD. Naidoo, Dhanjay Jhurry, Yaman Lochee, Archana Bhaw-Luximon, 2nd Nano TodayConference 2011, Marriott Waikola Beach Resort and Spa, Hawai’i, USA, 11-15 December2011.
18. Quantification of energy surfaces and molecular attributes for emulsified polymeric systems: An in silico analytico-mathematical interpretation of novel surfactant-electrolyte-stabilizednanoparticulate assemblies, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit,2nd Nano Today Conference 2011, Marriott Waikola Beach Resort and Spa, Hawai’i, USA,11-15 December 2011.
19. Hierarchically micro-meso-macroporous PLGA/PCL scaffolds for neural tissue engineering, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and D. Naidoo,2nd International symposium Frontiers in Polymer Science 2011, Lyon, France, in associationwith journal Polymer, 29-31 May 2011.
20. The development of an in situ forming implant for the treatment of solid tumors: Determination of the effect of methotrexate release on colon carcinoma cells and in vivo studies in the rat model,Ameena Wadee, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit and Clement Penny, 6thInternational Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), Durban,South Africa, 25-27 September, 2011.
21. Design and characterization of intravenously administered nanolipobubbles for targeted ovarian cancer therapy, Derusha Frank, Viness Pillay, Yahya E. Choonara and Lisa C. u Toit, 6thInternational Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), Durban,South Africa, 25-27 September, 2011.
22. Evaluation of the physicochemical and physicomechanical properties of optimized ciprofloxacin- and diclofenac-loaded co-blended alginate fibers for oramucosal delivery, Deanne Hazel, VinessPillay and Michael P. Danckwerts, 6th International Conference on Pharmaceutical andPharmacological Sciences (ICPPS), Durban, South Africa, 25-27 September, 2011.
23. In vivo determination of the bioresponsive potential of an intelligent intraocular implant, Lisa du Toit, Viness Pillay, Thirumala Govender, Trevor R. Carmichael and Yahya E. Choonara, Schoolof Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
24. Development of chlorpromazine-loaded, polycaprolactone based nanoparticles utilizing a novel melt-dispersion technique, Thiresen Govender, Viness Pillay, Yahya E. Choonara, Lisa C.du Toit,Girish Modi and Dinesh Naidoo, School of Therapeutic Sciences Research Day, University of theWitwatersrand, August 24, 2011.
25. A novel oral ghost drug delivery device for the injection free administration of salmon calcitonin, Angus Hibbins, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit and Pradeep Kumar, School ofTherapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
26. In silico theoretical molecular modeling for Alzheimer’s disease: The nicotine-curcumin paradigm in neuroprotection and neurotherapy, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, GirishModi, Dinesh Naidoo and Lisa C. du Toit, School of Therapeutic Sciences Research Day,University of the Witwatersrand, August 24, 2011.
27. An implantable nano-enabled bio-robotic intracranial device for the delivery of anti-aging drug in Alzheimer’s disease, Maluta S. Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit,Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
28. Pectin-mucin interactions: Implication and application in microsphere formulation for drug delivery, Felix Mashingaidze, Viness Pillay, Yahya E. Choonara, Vinesh Maharaj and Lisa C. duToit, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24,2011.
29. Fabrication and characterizations of an implantable nano-enabled Biorobotic Intracranial Device for enhance drug delivery into targeted neuronal cells of Alzheimer’s disease, Maluta StevenMufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo, LeithC.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting & Exposition, Washington ConventionCenter, Washington, DC, USA, 23-27 October, 2011.
30. Formulation and physicochemical characterization of surface-modified nanoliposomes by chelating ligands, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit,Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting &Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
31. Surface-modified nanoliposomes by chelating ligands modulates neurotoxicity associated with beta amyloid aggregation, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C.
du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting& Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
32. Development of functionalized nanoliposomes using Box-Behnken experimental design validate improvement of galantamine uptake by neuronal cells, Maluta Steven Mufamadi, Viness Pillay,Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E.
Iyuke, AAPS Annual Meeting & Exposition, Washington Convention Center, Washington, DC,USA, 23-27 October, 2011.
33. Elucidation of the cytotoxicity and intracellular uptake of a surface modified nanoliposomes by a chelating ligands, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit,Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting &Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
34. A triple-mechanism gastroretentive system for sustained delivery of levodopa, Ndidi C. Ngwuluka, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara and Lisa C. du Toit, 38th AnnualMeeting & Exposition of the Controlled Release Society (CRS), Gaylord National Hotel andConvention Center, National Harbor, Maryland, USA, July 30 - August 3, 2011.
35. Application of ligand-functionalize nanoliposomes to reduce the neurotoxicity associated with ?-amyloid aggregation in Alzheimer’s disease, Maluta Steven Mufamadi, Viness Pillay, Yahya E.
Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, 6thInternational Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), Durban,South Africa, 25-27 September, 2011.
36. An implantable nano-enabled Biorobotic Intracranial Device for neurotherapeutic applications, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, DineshNaidoo, Leith C.R Meyer and Sunny E. Iyuke, 6th International Conference on Pharmaceuticaland Pharmacological Sciences (ICPPS), Durban, South Africa, 25-27 September, 2011.
37. Robust design of biodegradable block-poly(ester-ether)s and multifunctional nanoconstructs for spinal cord injury intervention: Cellular uptake and nano-neuro-sealing of disrupted neuronalmembranes, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi,Dinesh Naidoo, R. Jeetah, Y. Lochee, A. Bhaw-Luximon, Dhanjay Jhurry, 4th InternationalConference on the Mechanics of Biomaterials and Tissues, Frontiers in Polymer Science, Centrede congrès, Lyon, France, 29-31 May, 2011.
38. Invited Plenary Speaker: Overview of the Preclinical Phase of Drug Delivery Technologies Developed at the Wits Drug Delievry Platform: A Case for Technology Transfer andCommercialization, Viness Pillay, Yahya E. Choonara and, Lisa C. du Toit, 17th ScientificMeeting of the South African Association for Laboratory Animal Science (SAALAS), University ofthe Witwatersrand, Johannesburg, South Africa, 9-11 March 2011.
39. Invited Keynote Speaker: In Vivo Evaluation of Novel Implantable Drug Delivery Technologies for Penetration of Restrictive Physiological Barriers, Viness Pillay, Yahya E. Choonara and Lisa C.
du Toit, 17th Scientific Meeting of the South African Association for Laboratory Animal Science(SAALAS), University of the Witwatersrand, Johannesburg, South Africa, 9-11 March 2011.
40. Invited Keynote Speaker: Preclinical Investigation of Novel Site-Specific Drug Delivery Technologies for Admisitration in the Large White Pig Model: A Surrogate for Human Studies,Viness Pillay, Lisa C. du Toit and Yahya E. Choonara, 17th Scientific Meeting of the SouthAfrican Association for Laboratory Animal Science (SAALAS), University of the Witwatersrand,Johannesburg, South Africa, 9-11 March 2011.
41. Invited Key Note Speaker: A smart composite polymeric scaffold for neural tissue
engineering, Viness Pillay and Yahya E. Choonara, 40th South African Chemical Institute (SACI)
National Convention and the 3rd Federation of African Chemical Societies (FASC) Meeting: A
Prelude Event to the International Year of Chemistry SACI 2011, First National Bank Building
West Campus, University of the Witwatersrand, Johannesburg, South Africa, 16-21 January
2011.
42. Toxicity of Multi-Walled Carbon Nanotubes in Saccharomyces cerevisiae, Chantelle Phillips, Sunny E. Iyuke, Viness Pillay, Karl Rumbold and Clarence Yah, 7th International Workshop onBiomedical Applications of nanotechnology, NanoMed 2010, Berlin, Germany, 2-3 December2010. Abstract available online at http://nm10.nanoevents.de/posters.html 43. Computational modeling and drug release characteristics of a pH-responsive interpolyelectrolyte complex, Ndidi C. Ngwuluka, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara, LisaC. du Toit and Riaz Khan, Annual Meeting and Exposition of the American Association ofPharmaceutical Scientists, Morial Convention Center, New Orleans, Louisianna, USA, 14-18November 2010. 44. Invited Plenary Presentation: A Novel Enzyme-Responsive Colon-Targeted Drug Delivery System for the Treatment of Local Colonic Pathologies, Valence M. K. Ndesendo, Priya Bawa,Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, and Pradeep Kumar, International Symposiumon Stimuli-Responsive Materials, University of Southern Mississippi, Hattiesburg, Mississippi,United States of America, 26-27 October 2010. Abstract available online at:http://www.stimuliresponsivematerials.org/symposia2010pub.htm 45. An Electro-Rheological Fluid as an In situ Forming Implant for Controlled Stimuli-Responsive Liberation of Diclofenac Sodium, Valence M. K. Ndesendo, Viness Pillay, Yahya E. Choonara,Refilwe B. Mosane, Pradeep Kumar and Lisa C. du Toit, International Symposium onStimuli-Responsive Materials, Hattiesburg, Mississippi, United States of America, 26-27 October2010. Abstract available online at:http://www.stimuliresponsivematerials.org/symposia2010pub.htm 46. A Novel Enzyme-Responsive Colon-Targeted Drug Delivery System for the Treatment of Local Colonic Pathologies, Priya Bawa, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.
K. Ndesendo and Pradeep Kumar, International Symposium on Stimuli-Responsive Materials,Hattiesburg, Mississippi, United States of America, 26-27 October 2010. Abstract available onlineat: http://www.stimuliresponsivematerials.org/symposia2010pub.htm 47. An Injectable In Situ Forming Implant for the Treatment of Solid Tumors Utilizing a Central Composite Design, Ameena Wadee, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, ClementPenny and Valence M.K. Ndesendo, International Symposium on Stimuli-Responsive Materials,Hattiesburg, Mississippi, United States of America, 26-27 October 2010. Abstract available onlineat: http://www.stimuliresponsivematerials.org/symposia2010pub.htm 48. Electro-Conductive Hydrogel for Controlled Stimuli-Responsive Liberation of Indomethacin,
Tong-Sheng Tsai, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh
Naidoo, Pradeep Kumar and Valence M.K. Ndesendo, International Symposium on
Stimuli-Responsive Materials, Hattiesburg, Mississippi, United States of America, 26-27 October
2010. Abstract available online at:
http://www.stimuliresponsivematerials.org/symposia2010pub.htm
49. A Pepsin-Responsive Polymeric Drug Delivery System for the Targeted Delivery of Loperamide HCl to the Small Intestine, Priya Bawa, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit,Valence M. K. Ndesendo and Pradeep Kumar, International Symposium on Stimuli-ResponsiveMaterials, Hattiesburg, Mississippi, United States of America, 26-27 October 2010. Abstractavailable online at: http://www.stimuliresponsivematerials.org/symposia2010pub.htm 50. A pH-responsive Mucoadhesive Membrane for Prolonged Oral Drug Delivery, Rubina P. Shaikh, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, Valence M.K. Ndesendo and PradeepKumar, International Symposium on Stimuli-Responsive Materials, Hattiesburg, Mississippi,United States of America, 26-27 October 2010. Abstract available online at:http://www.stimuliresponsivematerials.org/symposia2010pub.htm 51. Triple-layered solid matrix tablet configurations for constant multiple drug delivery, Kovanya Moodley, Viness Pillay, Yahya E. Choonara and Lisa C. Du Toit, Academy of PharmaceuticalSciences-UK-PharmSci- "The Science of Medicines", East Midlands Conference Center,University Park, Nottingham, UK, September 1-3, 2010.
52. A polyamide-based membranous device for specialized drug delivery, Thiresen Govender, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit, Girish Modi and Dinesh Naidoo, Academy ofPharmaceutical Sciences-UK-PharmSci- "The Science of Medicines", East Midlands ConferenceCenter, University Park, Nottingham, UK, September 1-3, 2010.
53. Elucidation of the potential of starch-based multipartculates for use as a platform in novel drug delivery systems, Yusuf Dawood, Viness Pillay, Yahya E. Choonara and Lisa C. Du Toit,Academy of Pharmaceutical Sciences-UK-PharmSci- "The Science of Medicines", East MidlandsConference Center, University Park, Nottingham, UK, September 1-3, 2010.
54. Novel polymeric approaches in the enhancement of nanobubble lifetime, Lisa C, du Toit, Thirumala Govender, Viness Pillay, Yahya E. Choonara, Tetsuya Kodama, Cross-FacultyPostgraduate Symposium, University of the Witwatersrand, Johannesburg, South Africa, October25-29, 2010.
55. Bioactive nano-liposhells and a polyamide-based membranous device for specialized central nervous system drug delivery, Thiresen Govender, Viness Pillay, Yahya E. Choonara, Lisa C. duToit, Girish Modi and Dinesh Naidoo, Cross-Faculty Postgraduate Symposium, University of theWitwatersrand, Johanesburg, South Africa, October 25-29, 2010.
56. Comparative inhibition of felodipine metabolism by naringenin and 8-arm-poly(ethylene glycol) employing freshly excised pig intestinal tissue, Pius Fasinu, Viness Pillay, Yahya E. Choonaraand Lisa C. du Toit, Annual Meeting of the American Association of Pharmaceutical Scientists,Morial Convention Center New Orleans, Louisiana, United States of America, November 14 - 18,The AAPS Journal. 2010; 12(S2), ISSN: 1550-7416 (electronic version), available from: 57. Computational modeling and drug release characteristics of a pH-responsive interpolyelectrolyte complex, Ndidi Ngwuluka, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara, Lisa C.
du Toit, Riaz A. Khan and Pradeep Kumar, Annual Meeting of the American Association ofPharmaceutical Scientists, Morial Convention Center New Orleans, Louisiana, United States ofAmerica, November 14 - 18, The AAPS Journal. 2010; 12(S2), ISSN: 1550-7416 (electronic 58. Physicochemical characterization of nanoparticles prepared from a basic ester of poly (acrylic) acid for sustained levodopa delivery, Ndidi Ngwuluka, Viness Pillay, Girish Modi, Dinesh Naidoo,Yahya E. Choonara, Lisa C. du Toit, Riaz A. Khan and Pradeep Kumar, Annual Meeting of theAmerican Association of Pharmaceutical Scientists Morial Convention Center New Orleans,Louisiana, United States of America, November 14 - 18, The AAPS Journal. 2010; 12(S2), ISSN:1550-7416 (electronic version), available from: 59. Design of a Biometrically Modeled Nanocomposite Neuro-Device for the Chronic Management of Aids Dementia Complex, Yahya E. Choonara, Viness Pillay, Sheri-Lee Harilall, Lisa C. du Toit,Riaz A. Khan, Girish Modi, Dinesh Naidoo, Sunny E. Iyuke and Leith Meyer, 37th CRS AnnualMeeting, Portland, Oregon, United States of America, 10-14 July 2010, published by theControlled Release Society, Minneapolis, Minnesota, USA, ISSN 1022-0178. 60. Podium Presentation: Pharmacokinetic Modeling Analysis of Drug Release from a Novel Doughnut-Shaped MiniTablet Intraocular Drug Delivery Device, Yahya E. Choonara, VinessPillay, Michael P. Danckwerts and Trevor R. Carmichael, 37th CRS Annual Meeting, Portland,Oregon, United States of America, 10-14 July 2010, published by the Controlled Release Society,Minneapolis, Minnesota, USA, ISSN 1022-0178. The WADDP has amassed over 25 PCT quality patents in the field of advanced drug deliverytechnology. Several patents have been geographically granted and many are currently underprosecution in the USA, UK, Europe, Japan and South Africa. Below is a representative list of patentsthat have been filed from original research emanating from the WADDP laboratories. 1. Monolithic tablet for controlled drug release, United States Patent # 6,090,411, Viness Pillay and 2. Compressed composite delivery system for release-rate modulation of bioactives, Reza Fassihi and Viness Pillay, United States Patent Application 20060024368, Filed on February 02, 2006.
3. A heterogeneously configured multiparticulate gastrointestinal drug delivery system, Lisa C. du Toit, Michael P. Danckwerts, Viness Pillay, Yahya E. Choonara and Shivaan Cooppan, SAComplete Application 2007/10786 (based on SA Provisional Patent Application 2006/08301)granted on October 8, 2008.
4. Oramucosal pharmaceutical dosage form, Rupal Patel, Viness Pillay and Michael P. Danckwerts, South African Provisional Patent Application 2005/07545 granted on April 20, 2009.
5. An improved monolithic drug delivery system, Sibongile R. Sibambo, Viness Pillay, Yahya E.
Choonara and Michael P. Danckwerts, SA Provisional Patent Application 2006/09747 granted on21 April, 2009.
6. An improved monolithic drug delivery system, Sibongile R. Sibambo, Viness Pillay and Yahya E.
Choonara, SA Complete Application 2008/01724 (based on SA Provisional Patent Application2006/09747) filed on February 22, 2008.
7. An improved monolithic drug delivery system, Sibongile R. Sibambo, Viness Pillay and Yahya E.
Choonara, PCT International Patent Application PCT/IB/2008000396 (based on SA ProvisionalPatent Application 2006/09747) filed on February 22, 2008.
8. A polyamide rate-modulated monolithic drug delivery system, Oluwatoyin A. Kolawole, Viness Pillay and Yahya E. Choonara, SA Provisional Application 2006/09748 granted on April 21, 2009.
9. A polyamide rate-modulated monolithic drug delivery system, Oluwatoyin A. Kolawole, Viness Pillay and Yahya E. Choonara, SA Complete Patent Application 2008/01723 (based on SAProvisional Application 2006/09748) filed on February 22, 2008.
10. A polyamide rate-modulated monolithic drug delivery system, Oluwatoyin A. Kolawole, Viness Pillay and Yahya E. Choonara, PCT International Patent Application PCT/IB/2008/000395 (basedon SA Provisional Patent Application 2006/09748) filed on February 22, 2008.
11. Multiparticulate gastrointestinal drug delivery system, Lisa Claire du Toit, Michael P. Danckwerts and Viness Pillay, South African Provisional Patent Application 2006/08301 filed on October 5,2006.
12. A heterogeneously configured multiparticulate gastrointestinal drug delivery system, Lisa C. du Toit, Michael P. Danckwerts, Viness Pillay, Yahya E. Choonara and Shivaan Cooppan, PCTInternational Patent Application PCT/IB2007/003727 (based on SA Provisional Patent Application2006/08301) filed on December 3, 2007.
13. A heterogeneously configured multiparticulate gastrointestinal drug delivery system, Lisa C. du Toit, Michael P. Danckwerts, Viness Pillay, Yahya E. Choonara and Shivaan Cooppan, SAComplete Application 2007/10786 (based on SA Provisional Patent Application 2006/08301) filedon December 12, 2007.
14. Oramucosal pharmaceutical dosage form, Rupal Patel, Viness Pillay and Michael P. Danckwerts, South African Provisional Patent Application 2005/07545 filed on September 19, 2005.
15. Oramucosal pharmaceutical dosage form, Rupal Patel, Viness Pillay and Michael P. Danckwerts, PCT International Patent Application PCT/IB06/002585 (based on SA Provisional PatentApplication 2005/07545) filed on September 19, 2006 (US and Japan).
16. Biodegradable implantable drug delivery device, Yahya E. Choonara, Michael P. Danckwerts and Viness Pillay, US Patent Application 11/288,035, Filed November 28, 2005.
17. A gastroretentive drug delivery system, Sarashnee Moonisami, Viness Pillay, Yahya E.
Choonara, and Caragh Murphy, SA Provisional Patent Application 2007/10997 filed onDecember 19, 2007.
18. A multi-configured oramucosal delivery system, Deshika Reddy, Viness Pillay and Yahya E.
Choonara, SA Provisional Patent Application 2007/10999 filed on December 19, 2007.
19. A stimuli-responsive drug delivery system, Priya Bawa, Viness Pillay and Yahya E. Choonara, SA Provisional Patent Application 2007/11000 filed on December 19, 2007.
20. A multi-layered device for drug delivery, Seshni Sewlall, Viness Pillay, Yahya E. Choonara and Zaheeda Khan, SA Provisional Patent Application 2007/10998 filed on December 19, 2007.
21. Rate modulated delivery of drugs from a composite delivery system, Kim Hobbs, Viness Pillay, Yahya E. Choonara and Bradley R. Parsons, SA Provisional Application 2008/07122 filed onAugust 19, 2008.
22. Membranous polymeric scaffold, Bongani Sibeko, Viness Pillay, Yahya E. Choonara, Girish M.
Modi, Sunny E. Iyuke and Dinesh Naidoo, Patent Application Filed, awaiting priority date.
23. Polymeric configuration for site-specific drug delivery, Viness Pillay, Sheri-lee Harilall, Samantha Pillay, Yahya E. Choonara, Girish M. Modi, Sunny E. Iyuke and Dinesh Naidoo, PatentApplication Filed, awaiting priority date.
24. A controlled release bioadhesive intravaginal polymeric device, Valence M.K. Ndesendo, Viness Pillay and Yahya E. Choonara, Patent Application Filed, awaiting priority date. 25. Development of a matrix for transmucosal drug delivery, Toyin A. Kolawole, Viness Pillay and Yahya E. Choonara, Patent Application Filed, awaiting priority date.
26. Improving the oral bioavailability of active pharmaceutical ingredients, Pius S. Fasinu, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, SA Patent Application Number 2010/03742, 31March 2010.
27. An oral multi-crosslinked nanocomposite-charged pharmaceutical dosage form for improved bioavailability of active pharmaceutical ingredients, Ndidi Ngwuluka, Viness Pillay, Yahya E.
Choonara and Lisa C. du Toit, SA Patent Application Number 2010/03741, 12 October 2010.
28. Development of a membranous oral pharmaceutical dosage form, Rubina P. Shaikh, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, SA Patent Application Number 2010/03740, 12October 2010.
29. A nano-enabled site-specific drug delivery device, Thiresen Govender, Viness Pillay, Yahya E.
Choonara, Lisa C. du Toit, Girish Modi and Dinesh Naidoo, SA Patent Application Number2010/3743, 12 October 2010.
30. Development of a polymeric stratified zero-order drug release tablet, Kovanya Moodley, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, SA Patent Application Number 2010/03744 31. An implant for the controlled release of drugs, Ameena Wadee, Viness Pillay, Yahya E.
Choonara and Lisa C. du Toit, SA Patent Application Number 2010/03745, 12 October 2010.
32. A stimuli-actuated implantable drug delivery device, Thomas Tsai, Viness Pillay, Yahya E.
Choonara and Lisa C. du Toit, SA Patent Application Number SA 2010/03746, 12 October 2010.
33. An intelligent inflammation-responsive multipolymeric implantable system, Lisa C. du Toit, Viness Pillay, Yahya E. Choonara, Thirumala Govender and Trevor R. Carmichael, SA PatentApplication Number 2010/03748, 12 October 2010.
34. A biodegradable nano-enabled implant for targeted cancer chemotherapy, Nthato Chirwa, Viness Pillay, Yahya E. Choonara, Pradeep Kumar and Lisa C. du Toit, SA Patent Application Number2010/03747, 12 October 2010.
35. An implantable device for targeted and prolonged drug delivery, Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, SA Patent ApplicationNumber 2010/07276, 12 October 2010.
36. A polymer engineered neural device, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, SA Patent Application Number 2010/07276, 12 October2010.

Source: http://www.wits.ac.za/pdf/15116/15116_waddp_15116_research_outputs.pdf

Hc439901930p

Current Perspective Coronary Heart Disease: Reducing The Risk A Worldwide View Gerd Assmann, FRCP; Rafael Carmena, MD; Paul Cullen, FRCPI; Jean-Charles Fruchart, PhD;Fabrizio Jossa, MD; Barry Lewis, FRCP; Mario Mancini, MD; Rodolfo Paoletti, MD;for the International Task Force for the Prevention of Coronary Heart DiseaseWorldwide, cardiovascular diseases are now the most risk increases

Adhd: the tip of the iceberg

ADHD: The Tip of the Problems and Summary This chapter can serve as a review for the reader, and can be reproduced for personal use by family members or teachers. Figure 1. The extended spectrum of problems experienced by people with ADHD. The classically discussed symptoms of ADHD are only the tip of the iceberg. We’ve Been Missing the Point “Johnny is very active!

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