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Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Abacavir
Acamprosate
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen (See also Paracetamol)
Acetaminophen with Codeine (see also Paracetamol with codeine)
Positive for Opiates (OPI, MOR)
Acetaminophen with Codeine (see also Paracetamol with codeine)
Positive for Opiates (OPI, MOR)
Acetic Acid
Acetophenetidin
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Acetylsalicyclic acid
Aciclovir
Adinazolam
Allobarbital
Positive for Barbiturates (BAR)
Alphenol
Positive for Barbiturates (BAR)
Alprazolam
Positive for Benzodiazepines (BZO)
Aluminum Chloride Hexahydrate
Aluminum Chloride Hexahydrate
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Aluminum Hydroxide
Alverine Citrate
Alverine Citrate
Aminopyrine
Amitriptyline
Positive for Tricyclic Antidepressants (TCA)
Amitriptyline
Positive for Tricyclic Antidepressants (TCA)
Amitriptyline
Positive for Tricyclic Antidepressants (TCA)
Amitriptyline
Positive for Tricyclic Antidepressants (TCA)
Amitriptyline
Positive for Tricyclic Antidepressants (TCA)
Amlodipine
Amlodipine
Ammonia/Ipeacuanha
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Amobarbital
Positive for Barbiturates (BAR)
Amobarbital
Positive for Barbiturates (BAR)
Amoxicillin or Amoxycillin
Amoxicillin or Amoxycillin
Amoxicillin or Amoxycillin
Amoxicillin or Amoxycillin
Ampicillin
Ampicillin
Ampicillin
Amylmetacresol
Anhydrol forte
Antabuse
Antipyrine
Antazoline Sulphate
Aprobarbital
Positive for Barbiturates (BAR)
Atenolol
Atenolol
Atenolol
Atenolol
Atenolol
Atenolol
Atenolol
Atenolol
Atorvastatin
Azlocillin
Baclofen
Baclofen
Barbital
Positive for Barbiturates (BAR)
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Beclometasone
Bendrofluazide
Bendrofluazide
Bendrofluazide
Bendrofluazide
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Bendrofluazide
Bendrofluazide
Bendrofluazide
Bendrofluazide
Benzalknonium
Benzocaine
Benzocaine
Benztropine
Benzydamine
Positive for Benzodiazepine (BZO) 200 cutoff
Benzylpenicillin
Bromazepam
Positive for Benzodiazepines (BZO)
Bromopheniramine
Bromopheniramine
Bromopheniramine
Budesonide
Budesonide
Budesonide
Buprenorphine
Positive for Buprenorphine (BUP)
Buprenorphine
Positive for Buprenorphine (BUP)
Buprenorphine
Positive for Buprenorphine (BUP)
Buproprion
Buproprion
Butabarbital
Positive for Barbiturates (BAR)
Butabarbital
Positive for Barbiturates (BAR)
Butalbital
Positive for Barbiturates (BAR)
Butalbital
Positive for Barbiturates (BAR)
Butethal
Positive for Barbiturates (BAR)
Canestan
Carbamate
Carbamazepine
Carbamazepine
Carbamazepine
Carisoprodol
Cephalexin
Cephalexin
Celecoxib
Cetirizine
Cetylpyridinium
Chloral Hydrate
Chlorazepate
Positive for Benzodiazepines (BZO)
Chlordiazepoxide
Positive for Benzodiazepines (BZO)
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chlorhexidine Gluconate
Chloroform
Chlorpheniramine Maleate
Chlorpheniramine Maleate
Chlorpheniramine Maleate
Chlorpromazine
Chlorprothixene
Chlorprothixene
Chlorprothixene
Chlorprothixene
Cimetidine
Cimetidine
Cimetidine
Cinnarizine
Ciprofloxacin
Citalopram
Clofibrate
Clobazam
Positive for Benzodiazepines (BZO)
Clonazepam
Positive for Benzodiazepines (BZO)
Clonazepam
Positive for Benzodiazepines (BZO)
Clonazepam
Positive for Benzodiazepines (BZO)
Clofibrate
Clomethazole
Clomethazole
Clotrimazole
Clotrimazole
Clotrimazole
Clozapine
Clozapine
Clozapine
Co-Amoxiclav
Co-Amoxiclav
Co-danthramar
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Codeine Phosphate
Positive for Opiates (OPI/MOR)
Co-Fluampicil
Combivir
Co-Phenotrope (atropine/diphenoxylate)
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Co-Phenotrope (atropine/diphenoxylate)
Co-Trimoxazole
Cyclobenazprine
Positive for Tricyclic Antidepressants (TCA)
Cyclosporin
Cyprohetadine
Positive for Tricyclic Antidepressants (TCA)
Cyproterone
Cyproterone
Cyproterone
Cyproterone
Cyproterone
Dantrolene
Delorazepam
Positive for Benzodiazepines (BZO)
Dequalinium
Desmopressin
Desmopressin
Desmopressin
Dexamethasone
Dexamethasone
Dexamethasone
Dexamethasone
Dexamethasone
Dexamethasone
Dexamethasone
Dexamphetamine Sulphate
Positive for Amphetamine (AMP)
Dexamphetamine Sulphate
Positive for Amphetamine (AMP)
Dexamphetamine Sulphate
Positive for Amphetamine (AMP)
Dextropropoxyphene
Positive for Propoxyphene (PPX)
Dextropropoxyphene
Positive for Propoxyphene (PPX)
Dextropropoxyphene
Positive for Propoxyphene (PPX)
Diazepam
Positive for Benzodiazepines (BZO)
Diazepam
Positive for Benzodiazepines (BZO)
Diazepam
Positive for Benzodiazepines (BZO)
Diazepam
Positive for Benzodiazepines (BZO)
Diclofenac Sodium
Diclofenac Sodium
Diclofenac Sodium
Diclofenac Sodium
Diclofenac Sodium
Diclofenac Sodium
Dicyclomine
Dicyclomine
Didanosine
Dihydrocodeine
Positive for Opiates (OPI/MOR)
Dihydrocodeine
Positive for Opiates (OPI/MOR)
Dihydrocodeine
Positive for Opiates (OPI/MOR)
Dihydrocodeine
Positive for Opiates (OPI/MOR)
Diltiazem
Diltiazem
Diltiazem
Dimethicone
Dimethicone
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Diphenhydramine
Diphenhydramine
Diphenhydramine
Diphenhydramine
Dipenoxylate with Atropine
Docusate Sodium
Donepezil
Dopamine
Dothiepin
Positive for Tricyclic Antidepressants (TCA)
Doxycycline
Doxycycline
Positive for Tricyclic Antidepressants (TCA)
Positive for Tricyclic Antidepressants (TCA)
Doxylamine
Positive for Methadone (MTD)
Droperidol
Droperidol
Droperidol
Duloxetine
Efavirenz
Positive for Cannabinoids (THC)
Urinary metabolite(s) only;
(parent compound is non-reactive)
Enoxaparin
Enoxaparin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Erythromycin
Estazolam
Positive for Benzodiazepines (BZO)
Ethambutol
Ethylmorphine
Positive for Opiates (OPI/MOR)
Fenofibrate
Ferrous Fumarate
Flucloxacillin
Flucloxacillin
Flucloxacillin
Flumazenil
Flunitrazepam
Positive for Benzodiazepines (BZO)
Fluoxetine
Fluoxetine
Flupentixol Decanoate
Flupentixol Decanoate
Fluphenazine
Flurazepam
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Folic Acid
Fusidic Acid (Sodium Fusidate)
Fusidic Acid (Sodium Fusidate)
Fusidic Acid (Sodium Fusidate)
Gamma-Hydroxybutyrate
Gemfibrozil
Gemfibrozil
Gentamicin Sulphate
Gentamicin Sulphate
Gentamicin Sulphate
Gliclazide
Gliclazide
Halazepam
Positive for Benzodiazepines (BZO)
Halazepam
Positive for Benzodiazepines (BZO)
Halazepam
Positive for Benzodiazepines (BZO)
Haloperidol
Hepatitis B Vaccine
Hydrochlorothiazide
Hydrochlorothiazide
Hydrocodone
Positive for Opiates (OPI/MOR)
and/or Oxycodone (OXY)
Hydrocodone
Positive for Opiates (OPI/MOR)
and/or Oxycodone (OXY)
Hydrocodone
Positive for Opiates (OPI/MOR)
and/or Oxycodone (OXY)
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Hydrocortisone
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Hydrocortisone
Hydrocortisone
Hydrocortisone-17-butyrate
Hydrocortisone-17-butyrate
Hydromorphone
Positive for Opiates (OPI/MOR)
and/or Oxycodone (OXY)
Hydromorphone
Positive for Opiates (OPI/MOR)
and/or Oxycodone (OXY)
Hydroxocobalamin
Hydroxychloroquine
Hydroxyzine
Hydroxyzine
Hyoscine butylbromide
Hyoscine butylbromide
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen
Ibuprofen
Indomethacin
Indomethacin
Indomethacin
Interferon Alfa
Interferon Alfa
Interferon Alfa
Interferon Alfa
Isoniazide
Isosorbide Dinitrate
Isosorbide Dinitrate
Isosorbide Dinitrate
Isosorbide Dinitrate
Isosorbide Dinitrate
Isosorbide Dinitrate
Isosorbide Dinitrate
Isosorbide Dinitrate
Koalin and Morphine Mixture
Positive for Opiates (OPI/MOR)
Koalin and Morphine Mixture
Positive for Opiates (OPI/MOR)
Koalin and Morphine Mixture
Positive for Opiates (OPI/MOR)
Ketoprofen
Ketoprofen
Ketoprofen
Lactulose
Lactulose
Lamotrigine
Positive for Phencyclidine (PCP)
Lansoprazole
Lansoprazole
Lisinopril
Lisinopril
Lisinopril
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Lofepramine
Positive for Tricyclic Antidepressants (TCA)
Lofepramine
Positive for Tricyclic Antidepressants (TCA)
Lofexidine
Loperamide
Loperamide
Loperamide
Loratadine
Lorazepam
Positive for Benzodiazepines (BZO)
Lormetazepam
Positive for Benzodiazepines (BZO)
Magnesium Alginate
Mannitol
Medazepam
Positive for Benzodiazepines (BZO)
Medazepam
Positive for Benzodiazepines (BZO)
Medazepam
Positive for Benzodiazepines (BZO)
Medazepam
Positive for Benzodiazepines (BZO)
Medazepam
Positive for Benzodiazepines (BZO)
Mefenamic Acid
Mefenamic Acid
Meperidine
Meperidine
Metoclopramide
Methadone Hydrochloride
Positive for Methadone (MTD)
Methadone Hydrochloride
Positive for Methadone (MTD)
Methadone Hydrochloride
Positive for Methadone (MTD)
d-Methamphetamine HCL
Positive for Methamphetamine (mAMP)
d-Methamphetamine HCL
Positive for Methamphetamine (mAMP)
d-Methamphetamine HCL
Positive for Methamphetamine (mAMP)
l-Methamphetamine HCL
Positive for Methamphetamine (mAMP)
Methylenedioxyamphetamine (MDA)
Positive for Amphetamine (AMP)
and Ecstasy (MDMA)
Methylenedioxyamphetamine (MDA)
Positive for Amphetamine (AMP)
and Ecstasy (MDMA)
Methylenedioxymethamphetamine (MDMA)
Positive for Methamphetamine (mAMP)
and Ecstasy (MDMA)
Methylenedioxymethamphetamine (MDMA)
Positive for Methamphetamine (mAMP)
and Ecstasy (MDMA)
Methylenedioxymethamphetamine (MDMA)
Positive for Methamphetamine (mAMP)
and Ecstasy (MDMA)
Methylenedioxymethamphetamine (MDMA)
Positive for Methamphetamine (mAMP)
and Ecstasy (MDMA)
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Metronidazole
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Morphine
Positive for Opiates (MOR, OPI)
Naloxone
Naltrexone
Naltrexone
Naltrexone
Naproxen
Naproxen
Naproxen
Naproxen
Naproxen
Naproxen
Naproxen
Nicotine
Nicotine
Nicotine
Nicotine
Nicotine
Nifedipine
Nifedipine
Nifedipine
Nifedipine
Nifedipine
Nitrazepam
Positive for Benzodiazepines (BZO)
Nitrazepam
Positive for Benzodiazepines (BZO)
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Norethindrone
Noscapine
d/l-Octopamine
Olanzapine
Orphenadrine
Orphenadrine
Orphenadrine
Oxazepam
Positive for Benzodiazepines (BZO)
Oxazepam
Positive for Benzodiazepines (BZO)
Oxymetazoline
Oxymetazoline
Oxytetracycline
Oxytetracycline
Oxytetracycline
Paracetamol (Acetaminophen)
Paracetamol (Acetaminophen)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paracetamol (Acetaminophen) /Codeine Preparations
Positive for Opiates (MOR, OPI)
Paroxetine
Paroxetine
Penicillin
Penicillin
Pentobarbital
Positive for Barbiturates (BAR)
Pericyazine
Pericyazine
Pericyazine
Pericyazine
Pericyazine
Pericyazine
Pericyazine
Pericyazine
Phenobarbitone (see also Phenobarbital)
Positive for Barbiturates (BAR)
Phenytoin
Possible Positive for Barbiturates (BAR)
Urinary metabolite(s) only;
(parent compound is non-reactive)
Phenytoin
Possible Positive for Barbiturates (BAR)
Urinary metabolite(s) only;
(parent compound is non-reactive)
Phenytoin
Possible Positive for Barbiturates (BAR)
Urinary metabolite(s) only;
(parent compound is non-reactive)
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Phenobarbital
Positive for Barbiturates (BAR)
Pholcodine
Positive for Opiates (MOR, OPI)
Pholcodine
Positive for Opiates (MOR, OPI)
Pholcodine
Positive for Opiates (MOR, OPI)
Pholcodine
Positive for Opiates (MOR, OPI)
Piperacillin
Piperacillin
Prazepam
Positive for Benzodiazepines (BZO)
Prazepam
Positive for Benzodiazepines (BZO)
Prednisolone
Prednisolone
Prednisolone
Prednisolone
Prednisolone
Procaine
Positive for Opiates (OPI, MOP)
Progesterol
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Promethazine
Positive for Tricyclic Antidepressants (TCA)
Propranolol
Propranolol
Propranolol
Propranolol
Pseudoephedrine
Pseudoephedrine
Pseudoephedrine
Pseudeophedrine
Ranitidine
Positive for Methamphetamine (M-AMP)
Urinary metabolite(s) only;
(parent compound is non-reactive)
Risperidone
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Salbutamol
Secobarbital
Positive for Barbiturates (BAR)
Sennosides
Sertraline
Potential Positive for Benzodiazepines (BZO)
Drugs of Abuse
Cross Reactivity Generic Name
COMPOUND (Generic Name)
COMPOUND (Trade Name)
Sodium Valproate
Sodium Valproate
Sodium Valproate
Temazepam
Positive for Benzodiazepines (BZO)
Testosterone
Testosterone
Testosterone
Testosterone
Testosterone
Thioridazine
Thyroxine Sodium
Tramadol
Tramadol
Tramadol
Tramadol
Trazodone
Trazodone
Trazodone
Triazolam
Positive for Benzodiazepines (BZO)
Valporic Acid
Venlafaxine
Potential Positive for Phencyclidine (PCP)
Venlafaxine
Potential Positive for Phencyclidine (PCP)
Warfarin Sodium
Warfarin Sodium
Split-Specimen Cup®
Muti-Drug
Cassette
Point of care medical diagnostic testing products

Source: https://www.rapidexams.com/v/vspfiles/assets/images/noble%20cross%20reaction%20chart.pdf