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Home : Material Safety Data Sheets - Infectious Substances : MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES
SECTION I - INFECTIOUS AGENT
NAME: Candida albicans
SYNONYM OR CROSS REFERENCE: Candidiasis, Thrush, Moniliasis
CHARACTERISTICS: Oval, budding yeast, produces pseudohyphae in culture
and in tissues and exudates
SECTION II - HEALTH HAZARD
PATHOGENICITY: Mycosis of superficial layers of skin or mucous membranes
(oral thrush, vulvovaginitis, paronychia, onychomycosis, intertrigo); ulcers or
pseudomembranes in esophagus, gastrointestinal tract or bladder;
hematogenous dissemination may produce lesions in kidney, spleen, lung,
liver, prosthetic cardiac valve, eye, meninges, brain
EPIDEMIOLOGY: Worldwide
HOST RANGE: Humans
INFECTIOUS DOSE: Unknown
MODE OF TRANSMISSION: Endogenous spread (part of normal human flora);
by contact with excretions of mouth, skin, and feces from patients or carriers;
from mother to infant during childbirth; disseminated candidiasis may originate
from mucosal lesions, unsterile narcotic injections, catheters
INCUBATION PERIOD: Variable
COMMUNICABILITY: Communicable for duration of lesions
SECTION III - DISSEMINATION
RESERVOIR: Humans (normal human flora)
ZOONOSIS: None
VECTORS: None
SECTION IV - VIABILITY
DRUG SUSCEPTIBILITY: Sensitive to nystatin, clotrimazole, ketoconazole,
fluconazole, amphotericin B for invasive candidiasis
DRUG RESISTANCE: Resistant strains have been described for all the above
antifungal drugs
SUSCEPTIBILITY TO DISINFECTANTS: Sensitive to 1% sodium hypochlorite,
2% glutaraldehyde, formaldehyde; only moderately sensitive to 70% ethanol
file://C:\DOCUME~1\ALEXHO~1.EUR\LOCALS~1\Temp\54UUZF0P.htm PHYSICAL INACTIVATION: Inactivated by moist heat (121°C for at least 15
min)
SURVIVAL OUTSIDE HOST: Survives outside of host, especially in moist,
dark areas
SECTION V - MEDICAL
SURVEILLANCE: Monitor for symptoms; microscopic demonstration of
pseudohyphae and/or yeast cells in infected tissue or fluid; confirmation by
culture
FIRST AID/TREATMENT: Administer antibiotic therapy as required
IMMUNIZATION: None
PROPHYLAXIS: None
SECTION VI - LABORATORY HAZARDS
LABORATORY-ACQUIRED INFECTIONS: 2 reported laboratory-acquired
infections with Candida
SOURCES/SPECIMENS: Sputum, bronchial washings, stool, urine, mucosal
surfaces, skin or wound exudates, CSF, blood
PRIMARY HAZARDS: Accidental parenteral inoculation, exposure of mucous
membranes to droplets and aerosols, ingestion
SPECIAL HAZARDS: None
SECTION VII - RECOMMENDED PRECAUTIONS
CONTAINMENT REQUIREMENTS: Biosafety level 2 practices, containment
equipment and facilities for the manipulation of this organism
PROTECTIVE CLOTHING: Laboratory coat; gloves when contact with
infectious materials is unavoidable
OTHER PRECAUTIONS: None
SECTION VIII - HANDLING INFORMATION
SPILLS: Allow aerosols to settle; wearing protective clothing, gently cover spill
with absorbent paper towel and apply 1% sodium hypochlorite, starting at
perimeter and working towards the centre; allow sufficient contact time (30 min)
before clean up
DISPOSAL: Decontaminate before disposal; steam sterilization, chemical
disinfection, incineration
STORAGE: In sealed containers that are appropriately labelled
SECTION IX - MISCELLANEOUS INFORMATION
Date prepared: November 1999
Prepared by: Office of Laboratory Security, PHAC
file://C:\DOCUME~1\ALEXHO~1.EUR\LOCALS~1\Temp\54UUZF0P.htm Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date. file://C:\DOCUME~1\ALEXHO~1.EUR\LOCALS~1\Temp\54UUZF0P.htm

Source: http://phoebe.colorado.edu/MSDS/Archive/Yeast/MSDS-Candida-albicans-Yeast.pdf

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