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Treating candidiasis final-sajnm
This article appeared in The South African Journal of Natural Medicine 2008, Issue 39, pp 72 – 80.
HEIDI DU PREEZ, PR SCI NAT
, is a professional natural scientist with a Masters degree in
Food Science. She is currently specialising in Nutritional Medicine. Heidi consults for
both the food and health industries. She began specialising in natural health while
living in the UK. Heidi uses a holistic, naturopathic approach, incorporating diet,
supplementation, detoxification and spiritual wellbeing into her treatment regimen.
Heidi serves on the Council of The South African Association for Nutritional Therapy
(www.saant.org) and she is also the author of the recipe book Naturally Nutritious
mail: firstname.lastname@example.org and website: www.naturalnutrition.co.za
Candida albicans is a common soil fungus. It is also found as part of the normal
microbial population of our body’s mucous membranes. Usually it does not cause
disease; however, on occasion it may cause infections of the throat, vagina and
In most people, the low pH created by the resident acid-forming bacteria of the
mucous membranes inhibits the growth of C. albicans
. However, conditions that
change the environment of the mucous membranes can lead to extensive growth of C. albicans
with resultant disease. Candida is a classic opportunistic pathogen,
normally kept in check but capable of flaring up under specific, predisposing
conditions. As pathogenic fungi, the dimorphic Candida can alternate between a
filamentous and unicellular form, depending on the environmental conditions of
nutrition, temperature and pH. Thus, as a part of normal flora, C. albicans
budding yeast; hyphal forms are produced only during tissue invasion. This can make
diagnosis of fungal diseases very difficult. The definite evidence of opportunistic
fungal infection usually depends on demonstration of the fungal elements in the
Patients with impaired host defences secondary to diseases such as leukaemia, AIDS, Hodgkin’s disease, neutropenia and other haematological diseases, or endocrinopathies including diabetes are particularly susceptible to fungal infections. In general, conditions and treatments that reduce the number or function of phagocytes or impaired cell-mediated immunity increase susceptibility to opportunistic mycoses, such as candidiasis.
is an overgrowth of Candida throughout the entire body. In the most severe cases, Candida can travel through the bloodstream to invade every
organ system in the body, causing a type of blood poisoning called Candida
septicaemia. Other names that have been given to this condition include Candida-
related complex, polysystemic candidiasis, chronic candidiasis and Candida
Any of the several species of the yeast Candida are capable of causing candidiasis. These organisms are members of the normal flora of the skin, mucous membrane and gastrointestinal tract. Candida species colonise the mucosal surfaces of all humans during birth or shortly thereafter. Of more than a hundred species of Candida several are part of the normal flora and are potential pathogens. C. albicans
causes most infections, followed by C. tropicalis.
The intact or physiologically normal epithelium is usually resistant to Candida invasion. However, Candida may invade if the skin and mucosa are traumatised or hormonally altered, or if the Candida attachment to endothelial cells is enhanced. Clinical manifestations are varied ranging from acute, through subacute to chronic. Involvement may be localised to the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs or the gastrointestinal tract, or become systemic as in septicaemia, endocarditis and meningitis.
The debate continues as to whether candidiasis exists in the body as the result, or the
cause, of some immunological diseases. SYMPTOMS
Because candidiasis can affect various parts of the body – the most common being
the mouth, ears, nose, toenails, fingernails, gastrointestinal tract and vagina – it can
be characterised by a wide array of symptoms. These include: • Gastrointestinal tract:
constipation, diarrhoea, colitis, abdominal pain, persistent
heartburn, intestinal gas and bloating, nausea, irritable bowel syndrome, ‘leaky gut’,
and bad breath. • Respiratory allergy:
rhinitis, sneezing and/or wheezing, canker sores, sore throat,
congestion, nagging cough, clogged sinuses, burning tongue, white spots on the
tongue and in the mouth. • Central nervous system:
mood swings, depression, memory loss, poor
concentration, anxiety, irritability, panic, ‘spaced-out’ feelings, autism, hyperactivity
and attention deficit disorders. • Urogenital problems:
rectal itching, impotence, prostatitis, vaginitis, kidney and
bladder infections, urinary frequency and urgency. • Menstrual abnormalities:
premenstrual tension, irregular menstruation, infertility, and
• Skin complaints:
acne, athlete’s foot, eczema, psoriasis and general ‘itchiness’.
• Other systemic symptoms:
headaches, eye disorders, muscle pain and weakness,
joint pain and stiffness, numbness in the face or extremities, tingling sensations, night
sweats, extreme chronic fatigue, food allergy/intolerances, craving for sugar, bread
or alcohol, sensitivity to perfume and chemicals, arthritis, fibromyalgia,
hypothyroidism, adrenal problems, and even diabetes. Candida can be spread
through the bloodstream to give rise to widely disseminated, deep-seated mycoses
such as endocarditis,2 in which there is infection and inflammation of the heart tissue.
Symptoms usually worsen in damp or mouldy places, or after consumption of foods containing sugar and/or yeast. Patients with Candida infections often also have food allergies. The symptoms of a food allergy or environmental sensitivity can also mimic those of candidiasis. To further complicate matters some patients with candidiasis go on to develop environmental sensitivities as well. Because of its many and varied symptoms this disorder is often misdiagnosed. The patient generally complains of ‘feeling sick all over’.
The various disparate symptoms of a patient suffering from candidiasis are actually
due to gastrointestinal disturbance (gut dysbiosis). There appears to be a relationship
between gut mucous membrane permeability and normal bowel flora.3 Dysbiosis
results in a gastrointestinal mucous membrane that becomes abnormally permeable
allowing the absorption of inadequately broken down peptides and the reabsorption
of toxins from the bowel lumen leading to pharmacological effects. EPIDEMIOLOGY
Many conditions predispose individuals to opportunistic Candida infection. Certain
physiological changes in otherwise healthy individuals provide the setting for
opportunistic candidiasis. The incidence of vaginal candidiasis is higher during
pregnancy (due to a rise in pH) and is also increased among diabetics and women
taking oral contraceptives, hormones or antibiotics. The vastly more complex
hormonal system of women possibly predisposes them to more potential trouble,
although men are certainly not immune to the Candida syndrome. It has been
assessed that 60% of cases occur in women, 20% in men and 20% in children.4
Infants are especially at risk if they are heavily exposed to Candida before the normal microbial flora of the gastrointestinal tract and skin have been established. An infected mother may pass the fungal infection to her newborn. Babies usually develop oral thrush, peri-anal and genital infections, gastroenteritis with severe diarrhoea, or prolonged and painful diaper rash. Interestingly, most adults with severe cases of candidiasis experienced some of their symptoms from early childhood.
The intact adult epithelium is normally impervious to Candida invasion, however, certain conditions increase the opportunity of superficial candidiasis. Any trauma, burn, abrasion or break in the epithelial integrity of the skin or gut provides an opportunity for Candida to penetrate the skin, mucosa or subcutaneous tissue. Excessive moisture and warmth increase the number of Candida on the skin. Endocrinological disturbances, such as diabetes mellitus, hypoglycaemia,5 hypoparathyriodism and Addison’s disease, result in an increased incidence of candidiasis.1 Many medical procedures designed to prolong life also increase the likelihood of life-threatening opportunistic infections. Immunosuppressive treatment, transplantation, steroid treatment and anti-bacterial antibiotics all reduce resistance to Candida. Patients with AIDS are highly susceptible to candidiasis, especially involving the mucosal surfaces of the oesophagus and oropharynx. Enteric candidiasis follows the administration of tetracycline and occurs also when the yeast population is supposedly suppressed by the concomitant use of anti-fungal antibiotics. Exposure to heavy metals or metal allergy (e.g. to mercury or titanium) are also predisposing factors which can lead to candidiasis.
Disruptive factors leading to dysbiosis of the gut with consequently increased
probability of candidiasis include stress, altitude changes, lack of breastfeeding,6 X-
ray radiation,7 starvation, parasitic organisms, diarrhoea and constipation (intestinal
flow rates),8, 9 low stomach acid, environmental toxins, alcohol and drug abuse,
stimulants, a diet high in refined carbohydrates and nutrient-poor diets. CLINICAL ASSESSMENT
Although laboratory tests for yeast diagnosis might be helpful, their interpretation is
not always straightforward and they can sometimes be misleading. Stool cultures can
also be misleading because if yeast is in its fungal form most of the cells are physically
attached to the intestinal lining and a stool culture can only detect the cells that
have broken off. Therefore faecal microflora may differ considerably from that of the
mucosal surface of the intestinal wall, and in any case, colonic flora differs from that
above the ileo-caecal valve.
Possibly one of the most reliable tests for elevated Candida levels is an organic acid urine test to detect by-products of yeast and fungi. Tartaric acid, a highly toxic substance that inhibits the supply of malic acid and that is needed for proper function of the Krebs cycle, is one of the organic acids found to be elevated in the presence of yeasts. The biochemical process, which is responsible for the production of most of the body’s energy, is therefore short-circuited leading to symptoms of weakness, foggy thinking, depression, chronic fatigue and muscle and joint pain. Elevated organic acids including tartaric acid and low levels of malic acid have been found in a large percentage of patients with fibromyalgia.10 Furthermore, it has
been shown that 80 - 90% of children with autism, attention deficit disorder and hyperactivity similarly have abnormal levels of yeast or fungal metabolites.11, 12 According to antibody studies it has been found that Candida is also involved in more than 80% of all cases of Crohn's disease and colitis.11
The most simple and accessible method for diagnosis is to use a questionnaire, which
indicates symptoms and history.13 The questionnaire comprises of symptoms typically
experienced by a Candida-sufferer, with a specific rating allocated to each
symptom. The question is not whether or not an individual has Candida, but rather
whether an overgrowth of Candida occurs. However, the surest way of confirming
the possibility of a yeast infection is to embark on an anti-yeast regimen and await
results. Since it is not dangerous to proceed with a trial yeast treatment programme,
in the final analysis this is actually the most reliable diagnostic test. TREATMENT REGIMEN
A safe, systematic naturopathic approach is recommended to bring Candida under
control. The following six steps together form an effective anti-yeast strategy. The
exclusion of any one of the steps will almost certainly lead to disappointing results.
This regimen should be followed for at least 3 months. 1. Boost the immune system.
Since a compromised immune system is the underlying
cause of candidiasis, it is essential to boost the system with a personal
supplementation programme. A wholefood supplement (e.g. a green ‘superfood’),
vitamin C (minimum 1 000 mg/day – ideally a buffered form) and essential fatty acids
should form the basis of such a programme. Supplements must be yeast and sugar-
free and digestive enzymes should be included. A 50% raw food diet is advisable,
which will include juicing (fresh vegetable juices). 2. Follow a strict anti-yeast diet to starve the Candida.
Yeasts are facultative
anaerobes and under anaerobic conditions utilise sugars via alcoholic or lactic acid
fermentations for their energy requirements. Therefore dietary glucose and sugar
promote fungal growth, so all forms of sugar – sucrose, glucose, maltose, fructose
and dextrose – must be avoided. No artificial sweeteners should be taken. However,
the herb stevia or xylitol could be used for sweetening, but ideally the patient should
overcome his or her ‘sweet tooth’! Refined carbohydrates add to the glucose load.
For at least the first 3 months, no fruit should be allowed. All foods containing yeast
must also be eliminated, because of the high degree of apparent cross-sensitisation
between Candida and other yeasts.14 Additional items to be eliminated are anything
fermented (vinegar and alcohol), containing mould (cheese and mushrooms) and
stimulants (tea, coffee etc.). A wheat-free diet must be followed, but ideally gluten-
free for at least the first 3 months. Soy products should also be avoided and dairy
products limited. An understanding of the reasons for the dietary restrictions and a determination to get well are the keys to perseverance, and only scrupulous adherence to the diet will achieve results.
However, patients might get so focussed on what not to eat that they almost stop
eating altogether. Emphasis should therefore also be placed on foods that are
allowed, e.g. animal and plant protein, vegetables and whole grains. The anti-yeast
diet must be strictly followed for at least 3 months. Even when Candida-related
symptoms have disappeared, it is advisable to keep within the diet guidelines for a
further year in order to consolidate the newly corrected balance of gut flora. Usually
by this time the patient feels so good on this diet that it becomes a natural way of
living. 3. Destroy the Candida through anti-fungal supplementation.
There are various
natural anti-fungal supplements on the market. Resistant strains of Candida develop
rapidly due to genetic mutation, therefore rotating the anti-fungals is very important.
Olive leaf extract with oleuropein has been found to be powerful against Candida.
Propolis is an alternative anti-fungal agent, which can also be used safely in
combination with olive leaf extract for greater effectivity. Caprylic acid is also known
to be useful for inhibiting an overgrowth of yeast organisms. Caprylic acid is best used
for destroying Candida in the gut. It is important to do this before attempting to
destroy Candida in outlying tissues, because the dysbiosis within the colon is the root
cause underlying Candida overgrowth in other areas of the body.
The essential oils of oregano, cloves and artemisia have great systemic anti-microbial
activity, being able to reach Candida, which has colonised in tissues of the body
beyond the gastrointestinal tract. Grapefruit seed extract (Citricidal) is a very
effective anti-fungal, available in capsule and liquid (ideal for douching) forms.
Kolorex is a patented herbal formula containing extracts of the New Zealand herb
horopito (Pseudowintera colorata)
and aniseed. Horopito contains a strong anti-
fungal agent called polygodial. Pau d’arco is an extremely useful herb for Candida
because it has both anti-fungal and immune-enhancing properties. Aloe vera and
Warburgia are other anti-fungal agents, as is oleic acid, making olive oil a useful
dietary supplement. Fresh garlic should be included in the diet, since it will not only
help to bring C. albicans
under control, but also other pathogens.11 4. Detoxification. C. albicans
releases toxins, a minimum of 79 known chemical
substances. There are over 900 species of yeast, including over 80 species of
Candida, at least six of which have been implicated as human pathogens. Since
each strain of C. albicans
is thought to contain up to 35 antigens and any one
person may harbour more than one strain, this suggests that the sensitisation potential
is enormous, quite apart from the infectious potential through tissue invasion. The sensitisation potential of C. albicans
is supported by studies showing that histamine release is stimulated by Candida antigens.11
As yeast is destroyed, the breakdown products and toxins released can cause extremely unpleasant symptoms, both as general malaise with nausea, aching limbs and depression, and locally as an apparent flare-up of previous symptoms in areas where the Candida has colonised. German dermatologist, Dr Karl Herxheimer, first described this response when C. albicans
was being destroyed by the use of anti-fungal substances.4 Usually referred to as ‘die-off’, it is not an unwanted reaction in the sense of a side-effect to a drug, and it should in fact be recognised as an encouraging sign. However, the symptoms can be far from pleasant and in some cases are sufficient to persuade the sufferer to give up the anti-yeast regimen.
It is therefore preferable to approach the regimen slowly but surely, and it is advisable to spend at least 1 month on the diet and immune-boosting supplement programme alone. These two factors are sufficient in many cases to cause a high degree of Herxheimer's reaction as die-off toxins start to circulate in the bloodstream. Once over this initial phase, anti-fungal supplements should be introduced at low levels and built up at intervals as die-off symptoms allow. The Candida sufferer should be encouraged to feel that s/he is in control of the situation by being responsible for the level of anti-fungal agents being taken.
It is very important to support the liver, since its detoxification pathways will have great difficulty in off-loading increased levels of toxins released by dead Candida, so they remain circulating in the bloodstream. The Ultra Clear range from Amipro is an ideal nutritional supplement to support the patient while severe die-off symptoms are being experienced. The Ultra Clear range could also be used long-term throughout the treatment regimen.
Constipation should be avoided at all costs because of the danger of reabsorption of toxins and Candida metabolites. Further, micro-organisms thrive on stagnant putrefactive matter within the intestines. Old impacted faeces do not pass from the body with ordinary bowel movements but require special techniques to dissolve the mucoid material.15 A seven-day tissue-cleansing programme together with colon irrigation16 is the most effective way of ridding the intestine of old accumulated toxic material and should be considered during the third month of the regimen. The tissue-cleansing programme also helps the body cells to release waste material. Other means of lymphatic cleansing, e.g. skin brushing and lymphatic drainage massage, are also recommended. Plenty of fluid (ideally distilled water) should be consumed on a daily basis to aid detoxification.
5. Restore dysbiosis.
It is important to re-establish strong colonies of bifido bacteria in
the intestines as fast as Candida is being destroyed. By re-inoculating the bowel with
proper symbiotic acid-producing bacteria, there is reduction in the compatibility of
the intestinal environment for yeast proliferation. Supplementation with a pre- and
probiotic as the last stage of the regimen is therefore essential. A prebiotic, e.g.
fructo-oliggosaccharides (FOS), supports the growth of the probiotic. Supplementing
with probiotics could also form part of the initial supplementation programme. 6. Emotional support.
When the die-off reaction manifests as emotional disturbances
(depression, morbidity, anxiety, panic, irritability and aggression), it is possible that the
immune system is reacting to the presence of excess toxins in the bloodstream so that
in addition to die-off there is also allergy to die-off! Furthermore, stress is a frequently
ignored factor, which keeps Candida supported even in the face of an otherwise
strict anti-Candida regimen. Stress is one of the greatest challenges to our immune
systems, putting pressure on nearly every organ and system in the body.
The Candida sufferer is trapped in a world of pain, confusion and foggy thinking. It
needs the objective insight and experience of a caring practitioner to find a way
through the minefield of possible problems, to pinpoint the cause of a plateau and
point the way forward. Bringing Candida under control is not an easy process; it
necessitates radical dietary changes and considerable self-discipline as well as
perseverance through periods of unpleasant die-off symptoms. Support from a
sympathetic practitioner is as valuable to the healing process as each and every
part of the treatment regimen. GENERAL
It is important to remove houseplants while on the treatment regimen, because of
cross-contamination 11,17 between Candida and mould, to which it is closely related,
as spores from damp soil become airborne in the room and are inhaled.14 Avoid
household chemical products and cleaners, chlorinated water, mothballs, synthetic
textiles, and damp and mouldy places, such as basements. Dentures can be an
ongoing source of Candida re-infection. Aloe vera, grapefruit seed extract or
propolis may be used as a refreshing mouthwash or gargle and aloe vera can be
used as an overnight denture soak. During the treatment regimen a patient should
not use oral contraceptives, hormone replacement therapy or steroid medications.
Sometimes it is evident that an anti-Candida approach alone is not sufficient to achieve restoration to health. In these situations it is worth considering the possibility of parasitic infection by such organisms as Blastocystis hominis
or Giardia lamblia
, or an overgrowth of potentially pathogenic bacteria such as Klebsiella, Helicobacter
The presence of one of these will not only cause symptoms in its own right, but may severely compromise the body's ability to bring Candida
under control. If no satisfactory results are achieved, treat for parasites towards the end of the anti-Candida regimen.
When Candida-related symptoms have disappeared, but food intolerance’s are still
experienced after the treatment regimen, a ‘leaky gut’ could be the cause. To treat
a leaky gut while Candida is still actively making holes in the intestinal lining tends to
be a waste of money. A leaky gut should therefore only be addressed after anti-
fungals and probiotics have been introduced.
Many people experiencing ill health are discovering that it is possible to regain health
if ways are found to bring an overgrowth of C. albicans
under control. References
1. Sullia SB, Shantharam S. General Microbiology. USA: Science Publishers Inc., 1998.
2. VanDemark PJ, Batzing BL. The Microbes – An Introduction to Their Nature and Importance.
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3. Draser B, Hill NJ. Human Intestinal Flora. London: Academic Press, 1974.
4. Trowbridge JP, Walker M. The Yeast Syndrome. New York: Bantam Books, 1986.
5. Balch Phyllis A, Balch JF. Prescription for Nutritional Healing. 3rd ed. New York: Avery, 2000.
6. Long SS, Swenson RM. Development of anaerobic fecal flora in healthy newborn infants. J Pediatr
7. Rasic J, Kurmann J. Bifidobacteria and Their Role.
Berkhauser: Verlag, 1983.
8. Gorbach SL. Population control in the small bowel. Gut
9. Banwell JG, et al. The microbial mass in the human large intestine. Gastroenterology
10. Russell J, et al.
Treatment of fibromyalgia syndrome with super malic: a randomized, double-blind,
placebo controlled, crossover pilot study. J Rheumatol
11. White E. Candidiasis – An Update. Educational leaflet. Lamberts Bulletin. Kent, UK: Lamberts
12. Shaw W.
Biological Treatments for Autism and PDD. USA: Health, 1998. Available from Health
13. Crook WG. The Yeast Connection: A Medical Breakthrough. 2nd ed. Jackson, Tenn.: Professional
14. Brostoff J, Challacombe SJ. Chronic Candidiasis and Allergy. In: Food Allergy and Intolerance.
Bailliere: Tindall, 1988.
15. Gray R. The Colon Health Handbook. 12th ed. USA, 1991.
16. Jensen B. Tissue Cleansing Through Bowel Management. California: Bernard Jensen Enterprises,
17. Santelmann H, et al. Effectiveness of nystatin in polysymptomatic patients. A randomised, double-
blind trial with nystatin versus placebo in general practice. Fam Pract
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