Referenz 1) Parkinson Study Group. Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. JAMA 2000: 284:1931-38. 2) Parkinson Study Group. Pramipexole vs Levodopa as Initial Treatment for Parkinson Disease. A 4-Year Randomized Controlled Trial Arch Neurol 2004: 61:1044-53. 3) Corbin A et al. Maintained pramipexole monotherapy treatment results in significantly lower dyskinesia rates in early Parkinson's disease: A result of the CALM-PD study after 4 years. Poster Presentation P-04 / 2.231 11 December 2007 XVII WFN World Congress of Parkinson's Disease and Related Disorders. 4) Fabbrini G et al. Levodopa-induced dyskinesias. Mov Disord 2007 22 (10), 1379-1389. 5) Constantinescu R et al. Impact of pramipexole on the onset of levodopa-related dyskinesias. Mov Disord 2007 Jul 15;22(9):1317-9. 6) Fahn S et al. Parkinson Study Group. Levodopa and the progression of Parkinson's disease. N Engl J Med 2004; 351:2498-2508. 7) Barone P et al. PRODEST - Depressive symptoms in Parkinson's disease: Pattern across scales. Poster Presentation P-01 / 1.167. 10 December 2007 XVIIth WFN World Congress of Parkinson's Disease and Related Disorders. 8) Möller JC et al. Long-term efficacy and safety of pramipexole in advanced Parkinson's disease: results from a European multicenter trial. Mov Disord 2005 May; 20(5): 602-10. 9) Rektorova I et al. Pramipexole and pergolide in the treatment of depression in Parkinson's disease: a national multicentre prospective randomized study. Eur J Neurol 2003; 10(4): 399-406. 10) Reichmann H et al. Pramipexole in routine clinical practice. CNS Drugs 2003; 17(13): 965-973. 11) Lemke MR et al. Depression and Parkinson's disease. J Neurol 2004 Sep;251 Suppl 6:VI/24-7. 12) Lemke MR et al. Anhedonia, depression, and motor functioning in Parkinson's disease during treatment with pramipexole. J Neuropsychiatry Clin Neurosci 2005 Spring; 17(2): 214-20. 13) Rektorova I et al. Cognitive performance in people with Parkinson's disease and mild or moderate depression: effects of dopamine agonists in an add-on to L-dopa therapy. Eur J Neurol 2005; 12: 9-15. 14) Goldberg JF et al. Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression. Am J Psychiatry 2004 Mar; 161(3): 564-6. 15) Künig G et al. Pramipexole, a nonergot dopamine agonist, is effective against rest tremor in intermediate to advanced Parkinson's disease. Clin Neuropharm 1999; 22: 301-305. 16) Barone P et al. Pramipexole versus sertraline in the treatment of depression in Parkinson's disease: a national multicenter parallel-group randomized study. J Neurol. 2006;253(5):601-7. 17) Maj J et al. The effect of repeated treatment with pramipexole on the central dopamine D3 system. J Neural Trans 2000; 107(12): 1369-1379. 18) Houben J et al. Pramipexole improves depressive and motivational symptoms in Parkinson's disease. Abstract no. P575, presented at MDS 2006; Kyoto, Japan. 19) Zhang ZX, et al. Worldwide occurrence of Parkinson's disease: An updated review. Neuroepidemiology. 1993;12:195-208. 20) de Rijk MC et al. Prevalence of Parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997;62:10?5. 21) Parkinson Study Group, Holloway RG et al. Pramipexole vs levodopa as initial treatment for Parkinson disease. Arch Neurol 2004; 61(7): 1044-1053. 22) Miyasaki JM et al. Practice parameter: Initiation of treatment for Parkinson's disease: An evidence-based review. Neurology 2002; 58; 11-17. 23) Barone P et al. Depressive symptoms in Parkinson's disease: Design and methods of an observational study. Mov Disord. Vol. 21, Suppl. 15, 2006: S476. 24) Barone P et al. Depression and antidepressant use in Parkinson's disease: Results from the PRODEST-PD study. Abstract P1122 poster presented at 11th Congress of EFNS, Brussels, 26 Aug 2007.
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NOTA CLINICA Embriopatía por isotretinoína. A propósito de una observación Introducción La isotretinoína es conocida desde hace años como uno de losteratógenos más potentes en humanos(1). Su uso terapéutico en adul-tos está limitado a casos de acné resistente, psoriasis e ictiosis. Serecomienda que no sea utilizada por mujeres en edad fértil y que,en cualquier caso, se e