Do you want to buy antibiotics online without prescription? http://buyantibiotics24h.com/ - This is pharmacy online for you!

Paper: chlorambucil plus rituximab produces better event-free survival in comparison with chlorambucil alone in the treatment of malt lymphoma: 5-year analysis of the 2-arms part of the ielsg-19 randomized study

Paper: Chlorambucil Plus Rituximab Produces Better Event-Free Surviv…5-Year Analysis of the 2-Arms Part of the IELSG-19 Randomized Study Last updated December 1, 2010. Please note that this site represents the latest program changes and differs from the print version in some details.
432 Chlorambucil Plus Rituximab Produces Better Event-Free Survival in Comparison with Chlorambucil Alone in the Treatment of MALT Lymphoma: 5-Year Analysis of the 2-Arms Part ofthe IELSG-19 Randomized Study Oral Session: Lymphoma - Therapy with Biologic Agents, excluding Pre-Clinical Models: Immunotherapy for Indolent Monday, December 6, 2010: 11:45 AM311 EFGH (Orange County Convention Center) Emanuele Zucca, MD1, Annarita Conconi, MD2, Giovanni Martinelli, MD3, Maurizio Martelli, MD4*, Catherine Thieblemont,
MD5, Peter W Johnson, MD, FRCP6, Armando Lopez-Guillermo, MD7, Reda Bouabdallah, MD8*, Alessandra Tucci, MD9*,
Umberto Vitolo, MD10, Bertrand Coiffier, MD, PhD11, Liliana Devizzi, MD12*, Fabrice Jardin, MD, PhD13*, Catherine Sebban,
MD14*, Graziella Pinotti, MD15*, Franck Morschhauser, MD, PhD16*, Ruth Pettengell, FRACP, PhD17*, Andre Bosly, MD18,
Emili Montserrat, MD7, Monica Bellei, MSc, PhD19*, Stefano A. Pileri, MD20, Christiane Copie-Bergman, MD, PhD21*, Elias
Campo, MD22*, Andrew Jack, PhD, MB23, Luca Mazzucchelli, MD24* and Franco Cavalli, MD, FRCP1

1Oncology Institute of Southern Switzerland, Bellinzona, Switzerland 2Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy 3Division of Hematology, European Institute of Oncology, Milan, Italy 4Division of Hematology, ''Sapienza'' University, Rome, Italy 5Hematology - INSERM U728- IUH-, Hopital Saint Louis, Paris, France 6School of Medicine CR UK Centre, Southampton General Hospital, Southampton, United Kingdom 7Department of Hematology, Hospital Clinic, Barcelona, Spain 8Institut Paoli-Calmettes, Marseille, France 9Ematologia, Spedali Civili, Brescia, Italy 10Chair of Haematology, University of Torino, Torino, Italy 11Centre Hospitalier Lyon-Sud, Pierre-Benite, France 12Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy 13Hematology, Centre Henri Becquerel, Rouen, France 14Centre Léon Bérard, Lyon, France 15UO Oncologia Medica, Ospedale di Circolo Fondazione Macchi, Varese, Italy 16Hematology Department, Hôpital Claude Huriez, Lille, France 17Haematology, St George's University of London, London, United Kingdom 18Hematology, UCL Mont Godinne, Yvoir, Belgium 19Dipartimento di Oncologia ed Ematologia, Universita' di Modena e Reggio Emilia, Modena, Italy 20Dept. of Hematology/Oncology, University of Bologna, Bologna, Italy 21Pathology Department, Hopital Henri Mondor, Paris Créteil Cedex, France 22Pathology, Hospital Clinic, Barcelona, Spain 23Hem. Malignancy Diagnostic Serv., St James's University Hospital, Leeds, United Kingdom 24Istituto Cantonale di Patologia, Locarno, Switzerland The IELSG-19 study was launched in 2003 by the International Extranodal Lymphoma Study Group to compare Chlorambucil alone versus the combination of Chlorambucil and Rituximab in the treatment of MALT lymphomas. Main contributors were the Italian Lymphoma Intergroup, the French GELA Group, the UK NCRI Group, the Catalan Hematology Group and the Oncology Institute of Southern Switzerland. MALT lymphoma pts with localized disease at any extranodal site who did not respond or were not suitable for local therapy (including H.pylori-negative gastric lymphomas or those who failed antibiotic therapy) were eligible, as well as those with disseminated or multifocal MALT lymphoma. Central histology review wasperformed. In arm A, Chlorambucil was given 6 mg/m2 daily p.o for 42 consecutive days (d 1-42). After restaging,responding patients and those with stable disease were kept on Chlorambucil 6 mg/m2 daily p.o for 14 consecutive days every 28 days for 4 cycles (d 56-70, 84-98, 112-126, 140-154). In arm B, Chlorambucil was given as in arm A, together withRituximab, 375 mg/ m2 iv on day 1, 8, 15, 22, 56, 84, 112 and 140. Because of the excellent initial recruitment a third arm with Rituximab alone (with a randomisation rate of 1:1:6) was introduced in 2006. The study planned accrual of 450 patients was reached in June 2010. A planned final analysis was performed according to protocol on the 227 pts enrolled in the first http://ash.confex.com/ash/2010/webprogram/Paper29197.html Paper: Chlorambucil Plus Rituximab Produces Better Event-Free Surviv…5-Year Analysis of the 2-Arms Part of the IELSG-19 Randomized Study two arms before introduction of the third treatment arm: 119 men (52%) and 108 women (48%); 204 (90%) with no previous treatment. The sample size allowed the detection of a 20% improvement in event-free survival (EFS, main endpoint) with 5% significance and 80% power. The treatment was completed as per protocol in 86% of the 227 pts analysed (89% in Arm A and 80% in arm B, respectively), in 60% without any dose adjustment or delay. The primary MALT lymphoma site was the stomach in 94 pts (41%);133 pts (59%) had a non-gastric presentation. In 79 pts (35%) the lymphoma involved more than 1 extranodal site. Lymph node involvement was present in 85 pts (37%); 133 pts (59%) had localized disease (Ann Arbor stage I-II). The ECOG performance status was 0 in 168 pts (74%). According to the international prognostic index (IPI) 133 pts (59%) had a low risk, 48 (21%) a low-intermediate risk , 39 (17%) an intermediate-high risk, and only 7 (3%) a high risk score. B-symptoms were present in 21 pts (9%) and LDH levels were higher than normal in 17 (7%). The main risk factors were equally distributed between the two arms. Outcome analysis was performed on all randomised patients on an intent-to-treat basis, median follow-up time is 60 months. The 5-year EFS was significantly better for the patients treated with Chlorambucil plus Rituximab (68%; 95% CI, 58%-76%) in comparison with those receiving Chlorambucil alone (50%; 95% CI, 40%-59%). Overall survival (OS) at 5 years was identical in the two arms (88%). There was no outcome difference between pts with gastric and non-gastric localization (note that H. pylori-positive gastric MALT lymphoma pts still responding to antibiotics were not eligible). Among the main clinical characteristics, more than one extranodal site, advanced stage, the presence of lymph nodal involvement and an unfavourable IPI were significantly associated with shorter EFS and OS. With respect to toxicity, both treatments were well tolerated and no unexpected side effects were recorded. Severe hematologic toxicity was uncommon in both arms but grade 3-4 neutropenia was significantly more frequent in the Chlorambucil plus Rituximab arm (19 vs. 2 episodes, p<0.001). In conclusion, this is the largest randomised trial ever conducted in MALT lymphoma. While awaiting the analysis of the whole study (to include the third arm with Rituximab alone, added later on), the current results confirm the activity of Rituximab in combination with chemotherapy but also indicate that differences in EFS and response rate may not automatically translate into improved Chlorambucil R-Chlorambucil value
http://ash.confex.com/ash/2010/webprogram/Paper29197.html Paper: Chlorambucil Plus Rituximab Produces Better Event-Free Surviv…5-Year Analysis of the 2-Arms Part of the IELSG-19 Randomized Study Disclosures: Zucca: Roche: Research Funding; Mundipharma: Honoraria, Research Funding; Celgene: Membership on an
entity’s Board of Directors or advisory committees. Off Label Use: Among indolent lymphomas, Rituximab is not specifically
approved for MALT lymphoma but only for follicular lymphoma. Johnson: Roche: Membership on an entity’s Board of
Directors or advisory committees. Vitolo: Roche: Membership on an entity’s Board of Directors or advisory committees.
Coiffier: Roche: Research Funding. Morschhauser: Roche: Honoraria. Pettengell: Roche: Honoraria.
http://ash.confex.com/ash/2010/webprogram/Paper29197.html

Source: http://www.ielsg.org/documents/ielsg19ash00.pdf

orchardsnutrition.co.za

ORDER FORM/PRICE LIST SEPTEMBER 2012 Description OMEGA-3 PHARMACEUTICAL FISH OIL SYW1 SYW Omega 3 Fish Oil caps (1g x 90 softgels) Professional Grade TGSYW Omega 3 Fish Oil caps (1g x 150 softgels) Professional Grade TGSYW Omega 3 Fish Oil caps (1g x 300 softgels) Professional Grade TGSYW DHA Essentials 120 capsules - small capsules for easy swallowingLife Support Omega 3 Fish Oil C

Chemwatch msds 431815

OSMOSE PROTIM - LOSP H3 (235WR) WOOD PRESERVATIVE ChemWatch Material Safety Data Sheet CHEMWATCH 431815 Issue Date: Thu 11-Mar-2004 CD 2004/3 Page 1 of 15 Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME OSMOSE PROTIM - LOSP H3 (235WR) WOOD PRESERVATIVE SYNONYMS PROPER SHIPPING NAME ORGANOTIN PESTICIDE, LIQUID, TOXIC, FLAMMABLE PRODUCT USE For us

Copyright © 2010-2014 Medical Pdf Finder