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Associate Research Professor
School of Computer Science
August 31, 2007 (3:30pm)
Can machine learning techniques be used to make the drug development process more efficient? Problem Statement
Given behavioral data gathered from animal trials on specific drug compounds, construct a
learning agent that can identify the class of a tested drug. Operational Definitions
Animal trials: Experiments conducted on rats in a laboratory where the rats are given a drug
compound (see below) and then continuously monitored for a set period of time in order to
record their reactions.
Behavioral data: Videos continuously recorded throughout the animal trials that capture all of the
animals’ externally visible behavior (e.g. sleeping, running, eating, scratching, and so on).
Combinations of chemical elements that are being tested to see if they have an
effect on a given disease or condition; for example, the drug Paxil is a drug compound that has
been shown to have an effect on the brain’s serotonin’s receptors that is beneficial to people
suffering from depression.
Drug classes: Pre-existing categories of drug compounds that describe the effect the drug
compound has in the body. For example, Paxil is classified as an antidepressant, meaning that it
has an effect that lessens symptoms of depression. Problem Description
The development process for new drugs is both time consuming and expensive. Years are spent
identifying potential drug compounds and testing these compounds in the laboratory. Because of
this, methods that can make these processes more efficient are in high demand. Schneider’s
work involves the use of machine learning algorithms to identify the class of a tested drug using
data from animal trials, a process that can help identify which compounds are actually targeting
the disease or condition they are being tested for. When using only data from tests of known
drugs, the drug class can be identified with 66.2% accuracy. By contrast, the drug class can be
predicted by chance alone with 7.7% accuracy. It can identify the specific drug 34.6% of the
time, compared to the 0.7% accuracy expected by chance.
Computer Science Perspective
Computer science techniques are well-suited to solve this kind of problem via active learning. A
computer can analyze a large dataset of behaviors and predict drug classes much more quickly
than a human can, saving both time and money. This research also helps computer scientists
develop more effective machine learning techniques. Description of Disciplines Involved
This research involves collaborations with biologists and researchers in the pharmaceutical
industry. Because this research focuses on drugs that target psychological conditions (such as
depression), neurobiologists, psychologists, and psychiatrists are also involved.
Actively Involved Disciplines
Computer science, pharmacology, neurobiology, psychology. Operational Definitions
Actively Involved Discipline: Any discipline from which one or more researchers made a
significant contribution to the research design and interpretation of the results. Typically, the
resulting research would add to the actively involved discipline’s body of knowledge in some
way, thus benefiting the discipline as a whole.
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