Calgb/swog c80405: a phase iii trial of irinotecan / 5-fu / leucovorin or oxaliplatin / 5-fu / leucovorin with bevacizumab, or cetuximab (c225), or with the combination of bevacizumab and cetuximab for patients with untreated metastatic adenocarcinoma o
Current Protocols in the Hematology /Oncology Clinic as of 06/01/2013 Breast 1. AMGEN 20110147: Randomized, Phase 2 Study to Estimate the Effect of Prophylactic Intervention with Naproxen or Loratadine on Bone Pain in Breast Cancer Subjects Receiving Chemotherapy and Pegfilgrastim 2. NSABP B-43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma in Situ Resected by Lumpectomy 3. NSABP B-47: A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of TC or Four Cycles of AC Followed by Four Cycles of Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Normal Invasive Breast Cancer 4. NSABP B-49: A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node- Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer 5. SWOG S1007: A Phase III Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less 6. SCUSF-0806: Phase II placebo-controlled trial of lisinopril and Coreg CR to reduce cardiotoxicity in patients with breast cancer receiving (neo)adjuvant chemotherapy with trastuzumab (Herceptin) 7. Pre-Activated: SWOG S1207: Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/NEU Negative Breast Cancer (Not open as yet) 8. Temporary Suspension to Accrual for Interim Analysis: WON CO09711: A Phase II Study of High Dose Estradiol in Metastatic Triple Negative Breast Cancer Colorectal 1. CALGB/SWOG C80702: A phase III trial of 6 versus 12 treatments of adjuvant FOLFOX plus celecoxib or placebo for patients with resected stage III colon cancer 2. NSABP P-5: Statin Polyp Prevention Trial in Patients with Resected Colon Cancer 1. AMGEN 20070782: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the
Long-term Safety and Efficacy of Darbopoetin Alfa Administered at 500 mcg Once Every 3
Weeks in Anemic Subjects with Advanced Stage NSCLC Receiving Multi-Cycle Chemotherapy
2. CALGB 30607: Randomized, Phase III, Placebo-Controlled Trial of Sunitinib as Maintenance Therapy in Non-Progressing Patients Following an Initial Four Cycles of Platinum- Based Combination Chemotherapy in Advanced, Stage IIIB/IV Non-Small Cell Lung Cancer 3. CALGB 30801: A Randomized Phase III Double Blind Trial Evaluating Selective COX-2 Inhibition in COX-2 Expressing Advanced Non-Small Cell Lung Cancer 4. ECOG E1505: A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (? 4 cm) - IIIA Non-Small Cell Lung Cancer (NSCLC) 5. ECOG E5508: Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed or Both Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Stage Non-Squamous Non-Small Cell Lung Cancer 6. SWOG S0819: A Randomized, Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/Bevacizumab with or without Concurrent Cetuximab in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) 7. WON CO11508: Randomized Phase II Study of Suramin and Docetaxel versus Docetaxel in Non-Small Cell Lung Cancer after Failure of First-Line Chemotherapy Hematology 1. Temporary Suspension to Accrual Due to IP Availability: ECOG E2905: Randomized Phase III Trial Comparing the Frequency of Major Erythroid Response (MER) to Treatment with Lenalidomide (Revlimid) Alone and in Combination with Epoetin Alfa (Procrit) in Subjects with Low- or Intermediate-1 Risk MDS and Symptomatic Anemia 2. SWOG S1117: A Randomized Phase II Study of Azactidine in Combination with Lenaldidomide vs. Azactidine Alone vs. Azactidine in Combination with Vorinostat for Higher-Risk Myelodysplatic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML).
Prostate 1. SWOG S1216: A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer Miscellaneous Waiting for Approval None Key: ECOG = Eastern Cooperative Oncology Group CALGB = Cancer and Leukemia Group B NCCTG = North Central Cancer Treatment Group NSABP = National Surgical Adjuvant Breast and Bowel Project SCUSF = SunCoast Community Clinical Oncology Program Research Base at the University of South FL. SWOG = Southwest Oncology Group WON = Wisconsin Oncology Network
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ABRIL NEGADO E SEMPRE RENOVADO Comemora-se a data de 25 de Abril de 1974, negando Abril. Mesmo muitos dos que viveram e recordam o espírito do Abril popular fazem-no agora mais como romagem de saudade aos belos tempos do PREC, do que pela afirmação concreta e convicta, nos dias de hoje, da luta pelos sonhos de então. No discurso oficial repetem-se as bonitas e velhas palavras gastas para