Aspirin

MSDS Number: A7686 --- Effective Date: 12/08/96
1. Product Identification
Synonyms: 2-(acetyloxy)benzoic acid; salicylic acid acetate; acetysalicylic acid
CAS No.: 50-78-2
Molecular Weight: 180.15
Chemical Formula: C9H8O4
Product Codes: 0033
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------- --------- Acetylsalicylic Acid 50-78-2 100% Yes 3. Hazards Identification
Emergency Overview
--------------------------
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN, EYES
AND RESPIRATORY TRACT. MAY CAUSE ALLERGIC RESPIRATORY REACTION. POSSIBLE
BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL DATA.
AFFECTS THE RESPIRATORY SYSTEM, LIVER, KIDNEYS, EYES, SKIN AND BLOOD.

J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience) ----------------------------------------------------------------------------------------------------------- Health Rating: 1 - Slight Flammability Rating: 1 - Slight Reactivity Rating: 0 - None Contact Rating: 1 - Slight Lab Protective Equip: GOGGLES; LAB COAT Storage Color Code: Orange (General Storage) ----------------------------------------------------------------------------------------------------------- Potential Health Effects
----------------------------------
Inhalation:
Causes irritation to the respiratory tract. Exposure may cause an allergy to develop.
Ingestion:
Extremely large oral doses may cause mild burning pain in the mouth and stomach, anorexia, nausea, vomiting,
intense thirst, diarrhea, dizziness, irritability, confusion, coma, teratogenic effects, and death from respiratory
failure. The mean lethal dose of aspirin by mouth probably lies between 20 and 30 grams in adults.
Skin Contact:
May cause irritation.
Eye Contact:
Causes irritation. Contact cause sever pain and may cause eye damage.
Chronic Exposure:
Repeated ingestion may cause tinitus, abnormal bleeding (gastric or retinal), gastric ulcer, weight loss, mental
deterioration, and skin eruptions. May cause kidney and liver damage in susceptible individuals.
Aggravation of Pre-existing Conditions:
Persons with a history of asthma or allergies to aspirin may be at an increased risk upon exposure to this
substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a
physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious
person. Call a physician.
Skin Contact:
In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes. Remove
contaminated clothing and shoes. Wash clothing before reuse. Get medical attention if irritation develops or persists. Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally.
Get medical attention immediately.
5. Fire Fighting Measures
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
explosion hazard. Minimum explosive dust concentration: 40 g/m3.
Fire Extinguishing Media:
Water spray, foam, or dry chemical.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with
full facepiece operated in the pressure demand or other positive pressure mode.
6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container. 7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from any source of heat or ignition. Isolate from incompatible substances. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. 8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
- ACGIH Threshold Limit Value (TLV): 5 mg/m3 (TWA)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the
contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH
document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face dust/mist respirator may be worn for up to ten times the exposure
limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier,
whichever is lowest. A full-face piece dust/mist respirator may be worn up to 50 times the exposure limit, or the
maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is
lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-
pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-
deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
Transparent, colorless crystals.
Odor:
Odorless.
Solubility:
1g/100g water @ 37C.
Specific Gravity:
1.40
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
140C (284F)
Melting Point:
135C (275F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable in dry air.
Hazardous Decomposition Products:
Decomposes to acetic acid and salicylic acids in the presence of moist air. Carbon dioxide and carbon monoxide
may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers, alkali hydroxides, boiling water, and antipyrine, aminopyrine, methamine, phenol, phenyl
salicylate, and sodium bicarbonate.
Conditions to Avoid:
Moisture.
11. Toxicological Information
Toxicological Data:
Oral rat LD50: 200 mg/kg; investigated as a mutagen, reproductive effector.
Reproductive Toxicity:
Reproductive effects recorded on humans. (RTECS)
--------\Cancer Lists\------------------------------------------------------ ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------------------------------------ ----- ----------- ------------- Acetylsalicylic Acid (50-78-2) No No None 12. Ecological Information
Environmental Fate:
When released into the soil, this material may leach into groundwater. When released into the soil, this material
may biodegrade to a moderate extent. When released into water, this material is not expected to evaporate
significantly. This material has an estimated bioconcentration factor (BCF) of less than 100. This material is not
expected to significantly bioaccumulate. When released into the air, this material may be moderately degraded by
reaction with photochemically produced hydroxyl radicals. When released into the air, this material may be
removed from the atmosphere to a moderate extent by wet deposition.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements. 14. Transport Information
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Acetylsalicylic Acid (50-78-2) Yes Yes Yes Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- ----- Acetylsalicylic Acid (50-78-2) Yes Yes No Yes --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- -------------- Acetylsalicylic Acid (50-78-2) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Acetylsalicylic Acid (50-78-2) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: NoSARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: NoReactivity: No (Pure / Solid) Prop 65:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.
Australian Hazchem Code: No information found.
Poison Schedule: S2
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR)
and the MSDS contains all of the information required by the CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO SKIN, EYES AND
RESPIRATORY TRACT. MAY CAUSE ALLERGIC RESPIRATORY REACTION. POSSIBLE BIRTH
DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL DATA. AFFECTS THE
RESPIRATORY SYSTEM, LIVER, KIDNEYS, EYES, SKIN AND BLOOD.
Label Precautions:
Do not breathe dust. Avoid contact with eyes, skin and clothing. Keep container closed. Use only with adequate
ventilation. Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to
an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact, immediately flush eyes or skin with plenty of water for at least 15
minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. In all cases call a physician.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
************************************************************************************************
Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no
representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person using this product.

Individuals receiving the information must exercise their independent judgment in determining its
appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO
REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING
WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR
THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT
BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR
RELIANCE UPON THIS INFORMATION.
************************************************************************************************
Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)

Source: http://win14.american.edu/safety/au/vault/000/000689.pdf

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