P D D R . M E D . B A R B A R A W I L H E L M Medical School of the Albert-Ludwig-Universität Guest student at the Ademiska Sjukhuset Uppsala, Sweden University of Mainz, practical year, Krankenhaus der Barmherzigen Brüder in Trier, Specialty Neurology. 1982 Medical Thesis at the Med. Fakultät Freiburg „Tumoren des Zentralnervensystems – retrospektive Studie aus strahlentherapeutischer Sicht“. 1981 – 1982 Resident at the Medical Department (Internal Medicine) Klinik Kues, Bernkastel-Kues, Germany 1983 family break Since 1986, Translation of „Clinical Decisions in Neuro-ophthalmology“ Burde, Savino, Trobe. Kohlhammer-Verlag, Stuttgart, Germany, 1989. Dep. Pathophysiology of Vision and Neuro- ophthalmology, University Eye Hospital Tübingen Contract to perform a scientific study on „Pupillenstörungen bei retrogenikulären Läsionen“ for the woman’s representative of the University Tübingen Establishing and developing a pupil research group at the Dep. Pathophysiology of Vision and Neuro-ophthalmology, University Eye Hospital Tübingen Establishing a pupillography laboratory: Infrared video pupillography, pupil campimetry and simultaneous assessment of accommodation. Development, introduction und application of these methods in normals Principal investigator of several investigator-initiated ophthalmological trials dealing with pupillography and pupil campimetry in Glaucoma Head of the pupillography laboratory of the University Head of research projects, inventions and construction of measuring devices, Supervising medical students in their thesis about pupil research, clinics Invention and development of the Pupillographic Sleepiness Test (PST) Technical solutions of long-time recording of pupil size Development of an algorithm for the determination of pupil diameter German patent for the special algorithm described above together with Helmut Wilhelm, MD und Dipl.-Phys. Holger Lüdtke (Bundespatentamt 19649542.3-35 Vigilanzprüfung mit Pupillographie). Since 1995 Introduction of the Pupillographic Sleepiness Test into German Sleep Medicine and Sleep Research Since 1997 Production and sales of the PST-device licensed by AMTech, 1997-2000 Main activities in research projects DFG WI 1066/3-1, WI 2000–2003: Head of research projects DFG 1928 1928/1-3 “Spontanverhalten der Pupille im Dunkeln als Maß für das Vigilanzniveau“ Research studies with the PST according to GCP (continuously since Development of an objective visual field test by Pupil Campimetry Anthocyan-Study “Efficacy of a bilberry extract standardised to a content of 25% anthocyanidines in improving the night vision of healthy volunteers: a double-blind, randomised, placebo controlled, cross-over trial over 2 x 28 days”, sponsored by Pharmaton SA (1999-2000) Since 1998: Steinbeis Transfer-Centre Biomedical Optics and Function Testing Tübingen FuE-research and development projects with industrial companies Development of Prototypes: SWIFT (Automated Swinging Flashlight Principal investigator of the European BRAION multicentre study, “Efficacy, tolerability and safety of 0.2% Brimonidine-Tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a three-month, double-blind, randomised, placebo-controlled trial”. Investigator-driven study, partially sponsored by Allergan. Head of the Sphere of Competence II Autonomous Nervous System and Safety Studies at the Steinbeis Transfer-Centre for Biomedical Optics and Function Testing Tübingen Principal Investigator of the Songha Night Clinical Trial, “A randomised, double-blind, double-dummy placebo-controlled cross-over trial to evaluate the presence of a hang-over effect in healthy adults after administration of Songha Night tablets (120 mg Valerian / 80 mg Lemon balm)”. Phase I Study. BI Trial 582.2 (2003) Main Investigator „Objective Assessment of daytime sleepiness under special shift conditions in public health services and construction sites“ sponsored by Bavarian Ministry of Health (Bayerisches Staatsministerium für Gesundheit, Umwelt und Verbraucherschutz“ (2003) Principal Investigator of „Double-blind, placebo-controlled randomized trial to investigate hang-over effects of 10 mg und 30 mg Oxazepam in healthy normals, assessed by the Pupillographic Sleepiness Test“ sponsored by Pharmaton SA, Lugano (2003) Main Investigator of the Study„Analysis of Driver Sleeepiness at German Roadhouses“ sponsored by Bavarian Ministry of Health (Bayerisches Staatsministerium für Gesundheit, Umwelt und Verbraucherschutz) (2004) Main Investigator of the Study „Light dimensions – Investigation of different illumination levels on visual function, alertness and wellbeing in the work place” sponsored by DaimlerChrysler AG, PVT/PBT Sindelfingen (2004) Main Investigator of the Study „Sleep-wake behaviour and daytime alertness in men and women over the age of 50 years“ sponsored by Bavarian Ministry of Health (Bayerisches Staatsministerium für Gesundheit, Umwelt und Verbraucherschutz“ (2005) Principal Investigator of pilot study „Investigation of human retinal function in a model of modified oxygen supply“ sponsored by Pharmaton, SA, Lugano (2005) Principal investigator of “Sensitivity of test paradigms for assessing anticholinergic effects on pupillary light reflex and glare – a randomized double-blind double-dummy placebo controlled cross over pilot methodology trial with tolterodine and oxybutynin in healthy volunteers” sponsored by Pfizer (A6121145) (2006) Coordination of the trial at the eye hospital (Prof. Bartz-Schmidt): „A Phase 2/3 Randomized, Controlled, Double-Masked, Multi-Center,
Comparative Trial, in Parallel Groups, to Compare the Safety and
Efficacy of Intravitreous Injections of 0.3 mg Pegaptanib Sodium
(Macugen), Given as Often as Every 6 Weeks for 2 years, to Sham
Injections, in Subjects with Diabetic Macular Edema (DME) Involving
the Center of the Macula“ (since 2007)
Preparation and coordination at the centre for ophthalmology: “A Multicenter, Patient-masked, Dose-escalation, Paired-eye Comparison, Sham-controlled, 6-Month (Plus 6-Month Extension) Study to Evaluate the Safety, Tolerability, and Effects on Visual Function of 100 µg, 200 µg, and 400 µg Brimonidine Tartrate Posterior Segment Drug Delivery System (Brimonidine Tartrate PS DDS) Applicator System in Patients with Retinitis Pigmentosa” (since 2007) Preparation and coordination at the centre for ophthalmology: “A two- arm, randomised, double-blind, placebo-controlled, multicenter phase II study to evaluate safety and tolerability and to explore the neuroprotective effect of atacicept as assessed by Optical Coherence Tomography (OCT) in subjects with Optic Neuritis (ON) as Clinically Isolated Syndrome (CIS) over a 36 week treatment course.” (since 2007) Principal Investigator at the Centre for ophthalmology and Coordinating Investigator: “Case-crossover study of PDE5 inhibitor exposure as a potential trigger factor for acute NAION” (since 2008) Head of Steinbeis Transfer Centre Autonomous Nervous System and Safety Studies, Ofterdingen. Coordination of the first human trial with a subretinal implant „A prospective open pilot study with functional placebo-control to evaluate the efficacy and tolerability of a Subretinal Implant in blind patients”. BMBF-Project 01 KP 0401 (start 2004) Coordination and monitoring of the trial: “Transcorneale Elektrostimulation zur Therapie retinaler Erkrankungen – eine randomisierte, einfach verblindete Pilotstudie“ (start 2007) Head of Steinbeis Transfer Centre eyetrial at the Centre for Ophthalmology, University of Tübingen Coordination of linical trials (industry or investigator-driven) according to the German pharmaceutical (AMG) and medical product laws (MPG) with innovative therapeutic approaches in ophthalmology and consulting of companies active in these fields. • German Ophthalmological Society (DOG) • German Society for Sleep Research and Sleep Medicine (DGSM) - Active member of the Vigilance Task Force, DGSM • European Sleep Research Society (ESRS) • European Aviation Group for Occupational Safety and Health • German Society of Occupational and Environmental Medicine • German Society for Traffic Medicine (DGVM) • Member of the women’s representative group of the medical faculty, university Tübingen. Replacement person of the women’s representative in appointment procedures of professorships at the medical faculty Tübingen. • Elfriede Aulhorn Award of the German Ophthalmological Society HABILITATION MEDICAL SCHOOL AT THE UNIVERSITY OF TÜBINGEN, • Field of Teaching: Experimental Ophthalmology since May 2006 • Inaugural Lecture: 3rd november 2006 • Rank 11 of the 50 best Medical Lecturers 2008 (out of 600 Lecturers ) • Born 1954 in Pirmasens, Germany. Married to Prof. Dr. Helmut Wilhelm; three children (born 1982, 1984 and 1987) • Hobbies: Lyrics; Knitting, Hiking, Swimming, Snorkling. • Other Interests: Autogenic Training teacher for normal subjects and • Languages: English and Swedish, Norwegian. • Member of the International Physicians for the Prevention of Nuclear Tel: (0 70 71) 298 4898 Fax: (0 70 71) 29 50 21 e-mail:


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