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Innovative Mixing Solutions
Case Study: RAM Mixing of Compounded Pharmaceuticals
Compounded Pharmaceuticals
RAM Mix Test Results
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
MIX NUMBER
Summary:
 All mixes were well under the FDA required “readily mixed” RSD value line of 4% -- RSD results typically less than 3%  Thorough mixing of various excipients and actives resulted from short mixing times in the RAM mixer – typically 2 to 4 minutes  RAM mixing out performs all conventional pharmaceutical mixing processes follow us
 RAM has demonstrated substantial value-add for mixing pharmaceutical powder products Note: Values in the graph are color coded to correspond with the materials on the reverse side. 130 North Main Street, Suite 630 - Butte, MT USA 59701 1.406.497.5333 (p) / 1.406.497.5206 (f) www.resodynmixers.com
Case Study (Continued): RAM Mixing of
Compounded Pharmaceuticals
Compounded Pharmaceuticals
Acceleration Time
Active Ingredient
Excipient
Progesterone
Lactose Monohydrate/Methocel E4M
Progesterone
Lactose Monohydrate/Methocel E4M
Domperidone
Domperidone
Methylprednisolone
Methylprednisolone
Testosterone
Lactose Monohydrate/Methocel E4M
Testosterone
Lactose Monohydrate/Methocel E4M
Budesonide
Avicel/Methocel E4M
Budesonide
Avicel/Methocel E4M
Ergotamine Tartrate
Lactose Monohydrate
Ergotamine Tartrate
Lactose Monohydrate
Estriol/Estradiol (50%/50%)
Lactose Monohydrate/Methocel E4M
Estriol/Estradiol (50%/50%)
Lactose Monohydrate/Methocel E4M
Levothyroxine Sodium
Avicel/Methocel E4M 35
Levothyroxine Sodium
Avicel/Methocel E4M 35
Levothyroxine Sodium
Avicel/Methocel E4M
Levothyroxine Sodium
Avicel/Methocel E4M
Liothyronine (T3)
Avicel/Methocel E4M
Liothyronine (T3)
Avicel/Methocel E4M
Liothyronine (T3)
Avicel/Methocel E4M
Liothyronine (T3)
Avicel/Methocel E4M
Domperidone 10mg Capsule (lactose):
Lactose Monohydrate
Domperidone 10mg Capsule (lactose):
Lactose Monohydrate
Domperidone 10mg Capsule (corn starch):
Corn Starch
Domperidone 10mg Capsule (corn starch):
Corn Starch
Domperidone 10mg Capsule (acidophilus):
Acidophilus
Domperidone 10mg Capsule (acidophilus):
Acidophilus
Domperidone 10mg Capsule (Loxasperse):
Loxasperse
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Domperidone 10mg Capsule (Loxasperse):
Loxasperse
Domperidone 10mg Capsule (Bimuno):
Domperidone 10mg Capsule (Bimuno):
130 North Main Street, Suite 630 - Butte, MT USA 59701 1.406.497.5333 (p) / 1.406.497.5206 (f) www.resodynmixers.com

Source: http://www.resodynmixers.com/wp-content/uploads/2013/08/Pharmaceutical-Mixing-Case-Study.pdf

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