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This drug can cause severe nausea and vomiting and the specialist may prescribe MoTiLiUM®
This group of medications acts on the dopamine
(domperidone) to address this side effect.
receptors and mimic dopamine. They can be used in combination with levodopa or alone.
The medications outlined in this brochure are available on prescription (PBS Listed).
0.125mcg; 0.25mcg; 1mg; 1.5mg
Currently NEuPRO® (rotigotine)
(applied to skin) patch dopamine agonist is
SIFROL ER®(Extended Release)
available on private prescription. The patch is
applied daily and comes in four strengths 2mg;
The patches should be refrigerated. in addition
Used in the
to the side effects of other dopamine agonists a rash at site of application may occur.
PERMAX® (pergolide mesylate)
This brochure provides information on the drugs used in Parkinson’s in layman’s terms. it is
PARLODEL® (bromocriptine mesylate)
designed to be used only as a guide. Please
consult your doctor, pharmacist or Parkinson’s
KRIPTON® (bromocriptine mesylate)
Compiled by Janet McLeod, Parkinson’s Nurse Specialist,
Parkinson’s Western Australia inc.
Side effects include nausea, dizziness, confusion and increased sleepiness. There have been
(Professional Advisory Board), Parkinson’s Western Australia
reports of associated gambling or increased
libido. Less frequent side effects associated with
Endorsed by Parkinson’s Australia inc. and distributed
some of these medications include pulmonary or
by Parkinson’s Western Australia inc.
peritoneal fibrosis and cardiac valve changes.
APOMINE® (apomorphine hydrochloride)
Used under specialist medical supervision.
Parkinson’s Australia Inc.
Given by intermittent subcutaneous injection,
continuous subcutaneous infusion or less
Parkinson’s disease is a progressive neurological
condition primarily related to the loss of dopamine producing cells within the brain. This brochure is
This group of drugs inhibits CoMT (an enzyme
intended as a guide to the medications used in the
acetylcholine and dopamine. They are useful
treatment of Parkinson’s. Specific questions relating
which metabolises levodopa), thus making more
in the treatment of tremor particularly in the
to your own medication should be directed to an
experienced health care professional.
The management of Parkinson’s can be chal enging
ARTANE® (benzhexol hydrochloride)
due to drug interactions and side effects. Response
BENZTROP® (benzhexol hydrochloride
to medications may change over time. Timing
decarboxylase inhibitor/CoMT inhibitor.
of medications may be critical to obtain optimal
COGENTIN® (benztropine mesylate
benefit with minimal side effects and varies for each
AKINETON® (biperiden hydrochloride)
Side effects (especial y in the older patient)
Levodopa remains the main drug used in the
include dry mouth, urinary retention, blurred
treatment of Parkinson’s. it is a precursor of dopamine
which is reduced in Parkinson’s. The addition of a
decarboxylase inhibitor enables larger amounts of levodopa to pass into the brain. These drugs are
TYPE B INHIBITORS
SINEMET® (L-dopa + carbidopa)
This is a CoMT inhibitor and must be taken with
monoamine oxidase which is responsible for the
break down of dopamine within the brain.
Side effects of both include an increase of
KINSON® (L-dopa + carbidopa)
levodopa effects (e.g. increased dyskinesia)
SELGENE® ELDEPRYL® (selegiline
and rarely diarrhoea. A harmless side effect is
5mg. it is important to take this
DuODOPA® (L-dopa + carbidopa)
drug early in the day (no later than 1200 hours).
A gel preparation administered by a permanent tube directly into the duodenum.
Side effects include sleep disturbance and it
MADOPAR® (L-dopa + benserazide)
Amantadine is an anti-viral agent that has anti-
may increase the side effects of levodopa.
DRUG INTERACTIONS WITH
100/25 HBS (Long Acting)
Rapid – 50/12.5; 100/25
SYMMETREL® (amantadine hydrochloride)
SELGENE® AND ELDEPRYL®
Rapid must be dissolved.
WARNiNG: Serious reactions may occur when patients
Side effects may include nausea, increased dreams,
taking selegiline are given Pethidine or certain types
Side effects are rare but may include insomnia,
dizziness and with long term use hallucinations and
of antidepressants. Check with your health care
dyskinesias (involuntary movements) may occur.
confusion and a mottled rash on the legs.
professional before taking ANY medication if you have been prescribed selegiline.
Exploring the molecular basis of combination drugs using ToxWiz For further information: Email: firstname.lastname@example.org Tel: +44 1223 703 137 Fax: +44 1223 858 794 Drug combinations represent intriguing possibilities for new therapies. The basic principle is that two active compounds can lead to effects that are more than the sum of their parts, possibly by simultaneously blocking
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