This drug can cause severe nausea and vomiting and the specialist may prescribe MoTiLiUM® Parkinson’s: Medications
This group of medications acts on the dopamine (domperidone) to address this side effect.
receptors and mimic dopamine. They can be used in combination with levodopa or alone. The medications outlined in this brochure are available on prescription (PBS Listed). SIFROL®(pramipexole)
0.125mcg; 0.25mcg; 1mg; 1.5mg
Currently NEuPRO® (rotigotine) a transdermal
(applied to skin) patch dopamine agonist is
SIFROL ER®(Extended Release)
available on private prescription. The patch is applied daily and comes in four strengths 2mg; Medications
CABASER® (cabergoline) 1mg; 2mg
The patches should be refrigerated. in addition Used in the
to the side effects of other dopamine agonists a rash at site of application may occur.
PERMAX® (pergolide mesylate)
Treatment of
This brochure provides information on the drugs used in Parkinson’s in layman’s terms. it is PARLODEL® (bromocriptine mesylate)
designed to be used only as a guide. Please consult your doctor, pharmacist or Parkinson’s KRIPTON® (bromocriptine mesylate)
Compiled by Janet McLeod, Parkinson’s Nurse Specialist, Parkinson’s Western Australia inc.
Side effects include nausea, dizziness, confusion and increased sleepiness. There have been (Professional Advisory Board), Parkinson’s Western Australia reports of associated gambling or increased libido. Less frequent side effects associated with Endorsed by Parkinson’s Australia inc. and distributed some of these medications include pulmonary or by Parkinson’s Western Australia inc.
peritoneal fibrosis and cardiac valve changes. CONTACT DETAILS
APOMINE® (apomorphine hydrochloride)
Used under specialist medical supervision.
Parkinson’s Australia Inc.
Given by intermittent subcutaneous injection, continuous subcutaneous infusion or less Parkinson’s
Australia Inc.
Australia Inc.
Parkinson’s disease is a progressive neurological COMT INHIBITORS
condition primarily related to the loss of dopamine producing cells within the brain. This brochure is This group of drugs inhibits CoMT (an enzyme intended as a guide to the medications used in the acetylcholine and dopamine. They are useful treatment of Parkinson’s. Specific questions relating which metabolises levodopa), thus making more in the treatment of tremor particularly in the to your own medication should be directed to an experienced health care professional.
STALEVO® (L-dopa/carbidopa/entacapone)
The management of Parkinson’s can be chal enging ARTANE® (benzhexol hydrochloride) 2mg; 5mg
due to drug interactions and side effects. Response BENZTROP® (benzhexol hydrochloride) 2mg
to medications may change over time. Timing decarboxylase inhibitor/CoMT inhibitor.
of medications may be critical to obtain optimal COGENTIN® (benztropine mesylate) 2mg
benefit with minimal side effects and varies for each AKINETON® (biperiden hydrochloride) 2mg
Side effects (especial y in the older patient) Levodopa remains the main drug used in the include dry mouth, urinary retention, blurred treatment of Parkinson’s. it is a precursor of dopamine which is reduced in Parkinson’s. The addition of a decarboxylase inhibitor enables larger amounts of levodopa to pass into the brain. These drugs are MONOAMINE OXIDASE
COMTAN® (Entacapone) 200mg
SINEMET® (L-dopa + carbidopa)
This is a CoMT inhibitor and must be taken with monoamine oxidase which is responsible for the break down of dopamine within the brain.
Side effects of both include an increase of KINSON® (L-dopa + carbidopa)
levodopa effects (e.g. increased dyskinesia) SELGENE® ELDEPRYL® (selegiline
and rarely diarrhoea. A harmless side effect is hydrochloride) 5mg. it is important to take this
DuODOPA® (L-dopa + carbidopa)
drug early in the day (no later than 1200 hours). A gel preparation administered by a permanent tube directly into the duodenum.
Side effects include sleep disturbance and it MADOPAR® (L-dopa + benserazide)
Amantadine is an anti-viral agent that has anti- may increase the side effects of levodopa.
100/25 HBS (Long Acting)
Madopar® Rapid – 50/12.5; 100/25
SYMMETREL® (amantadine hydrochloride)
NB. Madopar® Rapid must be dissolved.
WARNiNG: Serious reactions may occur when patients Side effects may include nausea, increased dreams, taking selegiline are given Pethidine or certain types Side effects are rare but may include insomnia, dizziness and with long term use hallucinations and of antidepressants. Check with your health care dyskinesias (involuntary movements) may occur.
confusion and a mottled rash on the legs.
professional before taking ANY medication if you have been prescribed selegiline.


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Exploring the molecular basis of combination drugs using ToxWiz For further information: Email: Tel: +44 1223 703 137 Fax: +44 1223 858 794 Drug combinations represent intriguing possibilities for new therapies. The basic principle is that two active compounds can lead to effects that are more than the sum of their parts, possibly by simultaneously blocking

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