Gastroentrologie, hpatologie et nutrition

Gastroentérologie, hépatologie et nutrition

Subventions

Titre:
Development of specific immunotherapies for treatment of autoimmune hepatitis Organisme: Fondation canadienne du foie Montant: Pratiques cliniques hospitalières et pluralisme urbain : L’arrimage d’une pédiatrie à la diversité de son milieu, PHASE II Organisme: Instituts de recherche en santé du Canada Montant: Chercheurs: Fortin S (PI), Alvarez F, Bibeau G, Laudy D Titre: Influence of sex organs and hormones on autoimmune hepatitis development Organisme: Instituts de recherche en santé du Canada Montant: Construire des ponts entre l’anthropologie et la santé des populations: arrimer la pédiatrie à l’obésité recherche du Centre universitaire de santé McGill Projet de recherche génétique et épidémiologique Organisme: Fondation québécoise de la maladie cœliaque Montant: Chercheurs: Dilali-Saiah I (PI), Dirks M (co-investigateur) Titre: Serotonin signalling in functional gastrointestinal disorders in children Organisme: Association canadienne de gastroentérologie - Instituts de recherche en santé du Création d’une biobanque des anomalies congénitales au Québec Organisme: Réseau de médecine génétique appliquée du Fonds de la recherche en santé du Essai randomisé contrôlé comparant Probaclac™ au placebo chez les enfants âgés de 8 à 18 ans souffrant d’intestin irritable Genetic epidemiology of early onset Crohn’s disease: Investigating the role of diet and xenobiotic metabolizing enzyme genes Organisme: Instituts de recherche en santé du Canada Montant: Chercheurs: Amre D (PI), Seidman E, Lévy E, Morgan K, Deslandres C (co-investigateurs) Service de gastroentérologie, hépatologie et nutrition - Rapport annuel 2008-2009 Identifying IBD risk alleles using halotype analysis Organisme: Institut national de la santé Montant: Chercheurs: Rioux J, Bitton A, Deslandres C et al. (co-investigateurs) Titre: Role of NK cell receptors and their ligands in the immunopathogenesis of Crohn’s disease Organisme: Fondation canadienne des maladies inflammatoires de l’intestin Montant: Chercheurs: Amre D, Deslandres C (co-investigateurs) Titre: Investigation of genetic markers that determine susceptibility and clinical phenotypes of inflammatory bowel diseases Organisme: Instituts de recherche en santé du Canada Montant: Chercheurs: Amre D (PI), Lévy E, Mack D, Seidman EG, Deslandres C (co-investigateurs) Titre: Thérapie immunosuppressive chez les patients pédiatriques avec maladies inflammatoires intestinales: modulation des fonctions immunes et du statut infectieux à Epstein-Barr virus Chercheurs: Deslandres C (PI), Haddad E, LeDeist F, Ovetchkine P, Alfieri C, Lévy E, Noble A, Bouthillier L, Willot S (collaborateurs) Trend in prescribing infliximab and clinical outcomes over an 8 year period in children with inflammatory bowel disease followed at a pediatric tertiary care center Organisme: Fonds Alexandre Lecavalier Montant: Évaluation des compétences en éthique et professionnalisme au cours de la formation pédiatrique: utilisation du test de concordance de script Organisme: Collège Royal du Canada Montant: Identification de gènes candidats de prédisposition à l’œsophagite éosinophilique Organisme: Association des gastroentérologues du Québec Montant: socioculturels de protection et de vulnérabilité dans l’apparition et l’évolution des troubles fonctionnels de l’intestin : les perspectives de l’enfant et de sa famille et leur recours aux services de santé Organisme: Fonds de la recherche en santé du Québec Montant: Chercheurs: Fortin S (PI), Bibeau G, Faure C, Rasquin A (co-investigateurs) Service de gastroentérologie, hépatologie et nutrition - Rapport annuel 2008-2009 Publications

Avec comités pairs
Alvarez F, Fortin S, Bibeau G. La Practica Pediatrica en un Medio Cultural Plural. Arch Argent Pediatr 2008;106(3):236-41. Amre DK, Mack DR, Israel D, Morgan K, Krupoves A, Costea I, Lambrette P, Grimard G, Deslandres C, Lévy E, Seidman EG. Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach. Inflamm Bowel Dis 2008;14(9):1214-8. Amre DK, Mack DR, Morgan K, Israel D, Lambrette P, Costea I, Krupoves A, Fegury H, Dong J, Grimard G, Deslandres C, Lévy E, Seidman EG. Interleukin 10 (IL-10) gene variants and susceptibility for pediatric onset Crohn’s disease. Aliment Pharmacol Ther 2009;29(9):1025-31. Amre DK, Mack DR, Morgan K, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Feguery H, Bucionis V, Deslandres C, Levy E, Seidman EG. Autophagy gene ATG16L1 but not IRGM is associated with Crohn’s disease in Canadian children. Inflamm Bowel Dis 2009;15(4):501-7. Bélanger S, Vanasse M, Spahis S, Sylvestre MP, Lippé S, l’Heureux F, Ghadirian P, Vanasse CM, Lévy E. Omega-3 fatty acid treatment of children with ADHD: A randomised, double-blind, placebo-controlled study. Pediatr Child Health 2009;14(2):89-98. Bouron-Dal Soglio D, Rougemont AL, Herzog D, Soucy G, Alvarez F, Fournet JC. An immunohistochemical evaluation of C4d deposition in pediatric inflammatory liver diseases. Hum Pathol 2008;39(7):1103-10. Chapados N, Seelaender M, Lévy E, Lavoie JM. Effects of exercise training on hepatic microsomal triglyceride transfer protein expression in rat. Horm Metab Res 2009;41(4):287-93. Connor FL, Hyman PE, Faure C, Tomomasa T, Pehlivanov N, Janosky J, Rudolph C, Liem O, Di Lorenzo C. Interobserver variability in antroduodenal manometry. Neurogastroenterol Motil 2009;21(5):500-7, e3. Debray FG, Boulanger Y, Khiat A, Décarie JC, Orquin J, Roy MS, Lortie A, Ramos F, Verhoeven NM, Struys E, Blom HJ, Jakobs C, Lévy E, Mitchell GA, Lambert M. Reduced brain choline in homocystinuria due to remethylation defects. Neurology 2008;71(1):44-9. Ethier-Chiasson M, Forest JC, Giguere Y, Masse A, Marseille-Tremblay C, Lévy E, Lafond J. Modulation of placental protein expression of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1): implication in pregnancy-related disorders or pathologies. Reproduction 2008;136(4):491-502. Fasano A, Araya M, Bhatnagar S, Cameron D, Catassi C, Dirks M, Mearin ML, Ortigosa L, Phillips A. Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Report on Celiac Disease. J Pediatr Gastroenterol Nutr 2008;47(2):214-9. Faure C, Giguere L. Functional gastrointestinal disorders and visceral hypersensitivity in children and adolescents suffering from Crohn’s disease. Inflam Bowel Dis 2008;14(11):1569-74. Grossman AB, Noble AJ, Mamula P, Baldassano RN. Increased dosing requirements for 6-mercaptopurine and azathioprine in inflammatory bowel disease patients six years and younger. Inflamm Bowel Dis 2008;14(6):750-5. Hammana I, Coderre L, Potvin S, Costa M, Berthiaume Y, Lavoie A, Chiasson JL, Lévy E, Rabasa-Lhoret R. Dichotomy between postprandial glucose and lipid profiles in adults with Cystic Fibrosis. J Cyst Fibros 2009;8(2):128-34. Herzog D, Soglio DB, Fournet JC, Martin S, Marleau D, Alvarez F. Interface hepatitis is associated with a high incidence of late graft fibrosis in a group of tightly monitored pediatric orthotopic liver transplantation patients. Liver Transpl 2008;14(7):946-55. Service de gastroentérologie, hépatologie et nutrition - Rapport annuel 2008-2009 Herzog DC, Delvin EE, Albert C, Marcotte JE, Pelletier VA, Seidman EG. triglyceride breath test (13C MTG-BT) in healthy children and children with cystic fibrosis under pancreatic enzyme replacement therapy (PERT), a pilot study. Clin Biochem 2008;41(18):1489-92. Lambert M, Delvin EE, Lévy E, O'Loughlin J, Paradis G, Barnett T, McGrath JJ. Prevalence of cardiometabolic risk factors by weight status in a population-based sample of Quebec children and adolescents. Can J Cardiol 2008;24(7):575-83. Lambert M, O’Loughlin J, Delvin E, Lévy E, Chiolero A, Paradis G. Association between insulin, leptin, adiponectin and blood pressure in a population-based sample of youth. J Hypertens 2009;27(5):1025-32. Leblond F, Seidah NG, Precourt LP, Delvin E, Dominguez M, Lévy E. Regulation of the proprotein convertase subtilisin/ kexin type 9 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2009;296(4):G805-15. Lipsich J, Rojas L, Alonso J, Teplisky D, Halac A, Alvarez F, Sierre S. Massive hematuria due to portal hypertension in a child with bladder augmentation for vesical exstrophy. J Pediatr Urol 2008;4(3):236-8. Marchand V. Nutrition in neurologically impaired children, a statement by the nutrition committee of the Canadian Pediatric Society. Paediatr Child Health 2009;14:395-402. Mark S, Gray-Donald K, Delvin EE, O'Loughlin J, Paradis G, Lévy E, Lambert M. Low vitamin D status in a representative sample of youth from Quebec, Canada. Clin Chem 2008;54(8):1283-9. Ntimbane T, Krishnamoorthy P, Huot C, Legault L, Jacob SV, Brunet S, Lévy E, Guéraud F, Lands LC, Comte B. Oxidative stress and Cystic fibrosis-related diabetes: A pilot study in children. J Cyst Fibros 2008;7(5):373-84. Pettersen G, Mouksassi MS, Théorêt Y, Labbé L, Faure C, Nguyen B, Litalien C. Population pharmacokinetics of intravenous pantoprazole in paediatric intensive care patients. Br J Clin Pharmacol 2009;67(2):216-27. Ravid Z, Bendayan M, Delvin E, Sane AT, Elchebly M, Lafond J, Lambert M, Mailhot G, Levy E. Modulation of intestinal cholesterol absorption by high glucose levels: impact on cholesterol transporters, regulatory enzymes and transcription factors. Am J Physiol Gastrointest Liver Physiol 2008;295(5):G873-85. Siitonen HA, Sotkasiira J, Biervliet M, Benmansour A, Capri Y, Cormier-Daire V, Crandall B, Hannula-Jouppi K, Hennekam R, Herzog D, Keymolen K, Lipsanen-Nyman M, Miny P, Plon SE, Riedl S, Sarkar A, Vargas FR, Verloes A, Wang LL, Kääriäinen H, Kestilä M. The mutation spectrum in RECQL4 diseases. Eur J Hum Genet 2009;17(2):151-8. Spahis S, Vanasse M, Bélanger S, Ghadirian P, Grenier E, Levy E. Lipid profile, fatty acid
composition and pro- and anti-oxidant status in pediatric patients with Attention-
deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2008;79(1-2):47-53.

Sans comités pairs
Drouin E, Leboeuf S, MacLellan AM. Les limites du stage d’observation. Le Collège 2008;48(4). Drouin E, Leboeuf S, MacLellan AM. Exercer la médecine au Québec – la voie du permis restrictif. Le Collège 2009;49(1). Drouin E, Leboeuf S, MacLellan AM. Nouvelles procédures de vérification à la source - Permis restrictifs et demandes d’équivalence du diplôme ou de la formation. Le Collège, printemps 2009;50(2). Drouin E, Leboeuf S, MacLellan AM. Permis restrictif à titre de résident en médecine. Le Collège 2009;50(2). Service de gastroentérologie, hépatologie et nutrition - Rapport annuel 2008-2009 Fortin S, Alvarez F, Bibeau G, Laudy D. Contemporary medicine: Applied human science or technological enterprise? Ethics Med 2008;24:41-50. Gauthier A, Bibeau G, Alvarez F. Créer des espaces de négociation entre famille et équipe
soignante lors de traitement de pointe en pédiatrie : illustrations et réflexions. Intervention, la
revue de l’Ordre des travailleurs sociaux du Québec 2008;129:58-68.
Chapitres de livres
Faure C. Approche gastroentérologique de la prise en charge des malformations anorectales et de leurs séquelles. In : Crétolle C, Sarnacki S, Révillon Y (eds). Les malformations anorectales. Sauramps Medical 2008:153-9. Lévy E, Delvin E, Ménard D, Beaulieu JF. Functional development of human fetal gastrointestinal tract. In: Lafond J, Vaillancourt C (eds). Human Embryogenesis: methods and protocols. Humana Press 2009:205-24. Lévy E, Spahis S. Fish oil in the gastrointestinal tract: emphasis on function and inflammation and potential efficacy in chronic disorders. In: Heikkinen Eetu P (ed). Fish Oils and Health. Nova Publisher 2008:185-96. Marchand V. Nutrition support for children with developmental disabilities. In: Kleiman RE (ed).
American Academy of Pediatrics, Pediatric Nutrition Handbook, 6e Édition, 2009:1500p.
Abrégés publiés
Darsigny M, Babeu J, Dupuis A, Furth E, Seidman E, Lévy E, Gendron F, Boudreau F. Loss of HNF4α reduces claudin-15 expression, impairs colonic epithelial permeability and leads to spontaneous chronic inflammation and crypt hyperplasia resembling inflammatory bowel disease. Can J Gastroenterol 2009;23:70A. Delaloëy JR, Kassir N, Litalien C, Théorêt Y, Alvarez F, Martin S, Lapeyraque L. Limited sampling strategies for Tacrolimus monitoring in pediatric liver transplant recipents. Pediatr Transplant 2009;13(Suppl 1):98. Halac U, Noble A, Giguère L, Faure C. Rectal sensory threshold for pain measured by barostat is a biological marker of irritable bowel syndrome and functional abdominal pain in children. Neurogastroenterol Motil 2008;20(S2):72. Khour H, Martin S, Alvarez F, Djilali-Saiah I. HLA-DQ2 molecule could increase the risk of developing celiac disease in patients with autoimmune hepatitis. Can J Gastroenterol 2009;23(Suppl A):77A. Mailhot G, Gauthier C, Franco A, Moreau A, Faure C. 6-OH melatonin sulfate excretion in children with functional gastrointestinal disorders. Gastroenterology 2009;134:S1. Moreau B, Lévesque D, Faure C. Association of ectopic pancreas and esophageal
atresia/tracheo-esophageal fistula in children. Gastroenterology 2009;134:S1.
Rayonnement

Conférence scientifique / Congrès /Colloque
Delaloëy JR, Kassir N, Litalien C, Théorêt Y, Alvarez F, Martin S, Lapeyraque L. Limited sampling strategies for Tacrolimus monitoring in pediatric liver transplant recipents. 5th Congress of the International Pediatic Transplant Association, Istanbul (Turquie), avril 2009. Service de gastroentérologie, hépatologie et nutrition - Rapport annuel 2008-2009 Delvin E, Lambert M, Lévy E, O’Loughlin J, Gray-Donald K, Paradis G. Vitamin D nutritional status and insulin resistance in a representative sample of Canadian youth. Annual Meeting of the American Association for Clinical Chemistry, Washington (DC), juillet 2008. Halac U, Noble A, Giguère L, Faure C. Rectal sensory threshold for pain measured by barostat is a biological marker of irritable bowel syndrome and functional abdominal pain in children. 3rd World Congress of Pediatric Gastroenterology and Nutrition, Iguassu Falls (Brésil), août 2008. Joint International meeting on Neurogastroenterology, Lucerne (Suisse), novembre 2008. Lochard N, Lévy E, Lambert M, Paradis G, O’Loughlin J, Delvin EE. Effect of paraoxonnase 1 and 2 polymorphisms on LDL size. Annual Meeting of the Canadian Society of Clinical Chemistry, St-Jean (Terre-Neuve), juin 2008. Luo ZC, Delvin E, Nuyt AM, Audibert F, Deal C, Shatenstein B, Julien P, Lévy E, Fraser W. Maternel glycemic status during pregnancy may program fetal insulin sensitivity. 5e International Symposium on Diabetes and Pregnancy, Sorrento (Italie), mars 2009. 3rd International Congress on Prediabetes and the Metabolic Syndrome, Nice (France), avril 2009. Mailhot G, Gauthier C, Franco A, Moreau A, Faure C. 6-OH melatonin sulfate excretion in children with functional gastrointestinal disorders. Digestive Diseases Week, Chicago (Illinois), mai 2009. Marchand V, Willot S, Rasquin AM, Alvarez F, Martin SR. Systemic progression of type IV glycogen storage disease (GSD IV) after liver transplantation; report of two cases. Congrès de la North American Society for Pediatric Gastroenterology and Nutrition, San Diego (Californie), octobre 2008. Marchand V, Lemale J, Bouthillier L, Pineault M, Ouimet A. Reversal of severe parenteral nutrition induced cholestasis with Omegaven. Congrès de la North American Society for Pediatric Gastroenterology and Nutrition, San Diego (Californie), octobre 2008. Mas E, Sassolas A, Lévy E, Collet X. Caractérisation d’un déficit en MTP (microsomal triglyceride transfer protein) chez une fratrie ayant également une agammaglobulinémie. 5e Congrès Annuel de la Nouvelle Société Française d’Athérosclérose, Biarritz (France), juin 2008. Moreau B, Lévesque D, Faure C. Association of ectopic pancreas and esophageal atresia/tracheo-esophageal fistula in children. Digestive Diseases Week, Chicago (Illinois), mai 2009. Nistor AL, Martineau LC, Arnason JA, Lévy E, Haddad PS. Inhibition of intestinal glucose transport by cree medicinal plant extracts. Annual Meeting of the Canadian Diabetes Association, Montréal (Québec), octobre 2008. Rodrigue-Way A, Demers A, Garofalo C, Lévy E, Tremblay A. Role of Scavenger receptor CD36 in cholesterol metabolism in hepatocytes. Annual Meeting of the Canadian Diabetes Association, Montréal (Québec), octobre 2008. Willot S, Noble A, Deslandres C. Methotrexate in the treatment of inflammatory bowel disease: an 8 year retrospective study on 91 patients treated in a Canadian pediatric IBD center. Canadian Digestive Disease Week, Banff (Alberta), mars 2009. Service de gastroentérologie, hépatologie et nutrition - Rapport annuel 2008-2009

Source: http://www.pediatrie.umontreal.ca/documents/rapport_2008-2009/gastroenterologie.pdf