Microsoft word - overallprogram25102012

Program Annual PhD Meeting – Thursday, 22 November 2012
Parallel sessions information (2 locations)
Parallel sessions A:
Big lecture hall (Room 30, Day chair: Laura Koenders)
Parallel sessions B:
Kapelzaal (Room 16, Day chair: Bernard Bloem)

Program
09:00 – 09:45 Registration/ Coffee & Tea
09:45 – 09:55 Welcome by day chair (big lecture hall)
10:00 – 11-30 Parallel session oral presentations:
Session 1A: Dementia – Chair: Wiep Scheper
Molecular changes during the development of Alzheimer's disease Marie Orre Reactive glia in Alzheimer’s disease – a genome wide study on glial (dys)function Qian Wang Glucocorticoid receptor protein expression in human hippocampus; changes in ageing, depression and Alzheimer’s disease Sasja Heetveld Regulation of tau exon 10 splicing: a shRNA screen of the human spliceosome Tara Arbab
Hippocampal codes of space in the Fmr1-KO mouse model of Fragile X mental
retardation

Session 1B: From gene regulation to gene therapy – Chair: Guus Smit
Joseph Ndika
Functional relevance of splicing in the creatine transporter gene
Elizabeth Moloney 
AAV-mediated delivery of neuropilin-1 receptor-bodies to skeletal muscle: a gene
therapy strategy to manipulate semaphorin 3A signalling at the NMJ of G93A-hSOD1
ALS mice
Stefan Hoyng
Developing an immunologically-inert reverse tetracycline controlled lentiviral vector for
gene therapy
Nitish Fagoe
Improved nerve regeneration by in vivo overexpression of ATF3 using an AAV dual
promoter vector

11:30 – 11:45 Coffee & Tea
11:45 – 13:00 Parallel session oral presentations:
Session 2A: Development – Chair: Hans van Hooft
Ewoud Schmidt Mesohabenular circuit development depends on axon-axon interactions and DCC–Netrin-1 signaling for target entry Martine Rosa Groen Developmental increase of tonic alpha-5 GABA-A subunit regulates dendritic excitability Julia Dawitz Synaptic mechanisms underlying early entorhinal cortex network development Sarah Burke Sex hormones, gender identity & the developing brain Session 2B: Astrocytes in health and disease – Chair: Vivi Heine
Aspects of GFAPdelta in adult neurogenesis RNA based silencing of GFAP isoforms The role of intermediate filaments in proliferating astrocytes Emanuele Zurolo MicroRNA-146a: a key regulator of astrocyte mediated inflammatory response
13:00 – 14:00 Lunch
14:00 – 14:45 Blitz session 1 (Big lecture hall)
14:45 – 15.15 Printer workshop (Kapelzaal)
15:15 – 16:15 Poster session I & Printers market
16:15 – 18:00 Parallel session oral presentations:
Session 3A: Addiction – Chair: Huib Mansvelder
When the blues bring the booze: the interaction between social defeat and alcohol-taking and alcohol-seeking behaviors in rats Bart Lubbers GABAergic neurotransmission in the dorsal medial prefrontal cortex regulates cue-induced reinstatement of nicotine seeking Matthijs Verhoog Nicotine facilitates spike-timing-dependent potentiation in layer 6 pyramidal neurons of the mouse medial prefrontal cortex Jan-Peter van Wieringen Characterization of 123I- and 18F-labeled pharmaceuticals for imaging dopamine D2- receptors in the high-affinity state Marieke Schouw Dopaminergic dysfunction in amphetamine users during a reward task before and after methylphenidate Marise Machielsen The effect of clozapine and risperidone on craving for cannabis in patients with schizophrenia, an fMRI study
Session 3B: Catching cognition – Chair: Carien Lansink
High throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene Marianne Klanker Phasic dopamine release in the striatum during spatial discrimination and reversal learning Bernard Bloem Cholinergic modulation of the medial prefrontal cortex in mice Nouk Tanke Single cell stimulation can influence perception Remi Soleman Neuroendocrine implications for cognition in adult transsexuals as clinical models
18:00 – 18:15 Coffee & Tea
18:15 – 18:45 Your PhD as Stepping Stone to Success (Big lecture hall)
19:00 – 20:30 Dinner
20:30 – 21:30 Evening Program “BrainBasher: Who’s the crook?!”
Program Annual PhD Meeting – Friday, 23 November 2012
Parallel sessions information (2 locations)
Parallel sessions A:
Big lecture hall (Room 30, Day chair: Emmeke Aarts)
Parallel sessions B:
Kapelzaal (Room 16, Day chair: Rolinka Schippers)

Program

08:00 – 09:15 Breakfast
09:15 – 09:55 Blitz session II
10:00 – 11:45 Parallel session oral presentations:
Session 4A: Neurological Disorders – Chair: Peter Burbach
Genetic differences in myelin and white matter connectivity in mouse recombinant inbred strains Catherine van Engen Identification and characterization of a new modifier gene for X-linked adrenoleukodystrophy Caroline Bruinsma Impaired cerebellar learning and Golgi cell-granule cell transmission in a mouse model of Angelman syndrome Sarah Janssen Gene expression and functional annotation of the human and mouse choroid plexus and in silico analysis of possible implications for glaucoma Vasil Mecollari Functional recovery from spinal cord injury in rats after expression of a soluble variant of the semaphorin/VEGF receptor Neuropilin-1 at the spinal lesion site Session 4B: Connectivity – Chair: Gerard Borst
Function of tomosyn-2 in the mammalian nervous system C2 domain proteins and their role at the synapse Pre-synaptic protein complexes identified by Interaction Proteomics Zimbo Boudewijns Layer specific spiking properties and the occurrence of active calcium events in the prelimbic prefrontal cortex of the rat Paolo Bazzigaluppi Properties of the nucleo-olivary pathway: an in vivo whole-cell patch clamp study
11:45 – 12:45 Lunch
12:45 – 13:45 Poster session II

Parallel session oral presentations:
Session 5A: New tools in fundamental and clinical neuroscience – Chair: Klaus
Linkenkaer Hansen
Torben Hager The dynamics of conditioned contextual fear: long-term monitoring of avoidance and risk assessment of mice in a novel automated home cage system Alexander Diaz The Amsterdam Resting State Questionnaire: a novel tool to measure and characterize resting-state cognition Pieter Klein GMOM analogues for PET imaging of the NMDA receptor: synthesis and evaluation Esther Lips Gene-set association analysis in complex traits Adrian Negrean Pushing the limits of two-photon microscopy Mireille Nieuwenhuis Prediction of disease status and illness course in schizophrenia patients using structural MRI brain pattern classification Session 5B: Vision – Chair: Alexander Heimel
CRB2 and CRB1 in retinal development and maintenance GABA-A agonist reduces visual awareness: a masking-EEG experiment Annelinde Vandenbroucke The influence of object knowledge on color representation in early visual areas Marie-Alice Gariel-Mathis Figure-ground modulation in macaque V1: the role of feedback from V4 Iris Groen Man-made or natural? Tracking neural processing of scene gist using single-trial EEG
15:15 – 15:30 Coffee & Tea
15:30 – 16:30 Swammerdam lecture by Prof. John-Dylan Haynes (Big lecture hall)
Charité - Universitätsmedizin, Berlin Chair for Theory and Analysis of Large Scale
Brain Signals, Director of Berlin Center for Advanced Neuroimaging Bernstein Center
for Computational Neuroscience
Decoding and Predicting Human Decisions

16:30 – 17:00 Awards & closing remarks
 
Blitz Session I – Thursday, 22 November 2012, 14:00 – 14:45
Roeland Struik
Rolinka Schippers
Sanne Menning
Rebecca Steketee
Ozlem Korucuoglu
Andrea Rosenberger
Baukje van der Star
Karlijn Doorn
Daphne Vogel
Lucija Abramovic
Moran Cohn
Margherita Farina
David Hondius
Rozan Vroman
Maria Fernanda Vinueza Veloz
Marcia Spoelder
Judith van der Harg
Emmeke Aarts
Nikhil Pandya
Loek van der Kallen
Johan Winnubst
Cillian King
Jasper Stroeder
Borbala Duray
Bruno Dagnino

Blitz Session II – Friday, 23 November 2012, 09:15 – 09:55
Irina Poslawsky
Roy Cox
Carly Sweegers
Judy Luigjes
Niels Gerrits
Ashutosh Dhingra
Oscar Stassen
Lieke Kros
Marloes Prins
Sarah Moens
Sanne van Rooij
Marta Ruiperez Alonso
Carmen Rietdijk
Jesse Veenvliet
TianTian Wang
Nawal Bahia el Idrissi
Melissa Lopes Pinheiro
Philip Nijland
Debbie Hendrickx
Myrle Kemperman
Niels Kloosterman
Karen Carney
Anna Karataeva
Ioannis Kramvis
Julia Kurps
Joachim Kutzera
Poster Session I, Thursday 22 November 2012, 15:15 – 16:15
Group A: Addiction
Elisabeth Abs
1. Roeland Struik
Metabotropic glutamate receptor 5 antagonist MPEP reduces spontaneous recovery of nicotine
seeking
2. Jochem Jansen
A meta-analysis on the effects of non-invasive neuro-stimulation on craving levels in substance
dependence
3. Han de Jong
Towards an animal model for food addiction
4. Rolinka Schippers
Deep brain stimulation of the nucleus accumbens core reduces relapse to heroin seeking
Group C: Cognition 1
Pascal Bielefeld
Paul Mertens
9. Sanne Menning
Prospective multimodality MRI study into cognitive dysfunction in breast cancer patients – preliminary
baseline results
10. Rebecca Steketee
Focal hypoperfusion in early dementia as assessed by arterial spin labeling magnetic resonance (MR)
11. Susanne Van Veluw
In vivo detection of cerebral cortical microinfarcts with high resolution 7T MRI
12. Lara Wierenga
Developmental trajectories of cortical thickness, surface area and volume are discrete
Group E: Cognition 2
Renske Raaphorst
Rozanna Meijboom
17. Mitzy Kennis
Reduced default mode network resting state functional connectivity in deployed veterans with PTSD
18. Ozlem Korucuoglu
The effect of acute alcohol and stimulus salience on conflict monitoring and error processing
19. Danique Jeurissen
Figure-ground modulation in the primary visual cortex of the macaque monkey
20. Luuk van der Velden
Local network synchronization in the ventral tegmental area
Group G: Degeneration 1
Anne-Lieke van Deijk
25. Veerle Eggens
The role of RNA processing genes in pontocerebellar hypoplasia
26. Nathaly Espitia Pinzon
Astrocyte-derived TG2 contributes to ECM production and aggregation, and cell adhesion
27. Andrea Rosenberger
Protein kinase activity profiling on cerebrospinal fluid to find diagnostic biomarkers for Alzheimer’s
disease
28. Berend van der Wildt
Development of a positron emission tomography (PET) tracer for in vivo determination of tissue
transglutaminase activity in neurodegenerative diseases
29. Maria Renner
Role of the GluR3-containing AMPA receptor in the maintenance of memories and Alzheimer’s
disease
Group I: Diseases 1
Anna Bennis
Sanne Verkooijen
34. Jamie Lim
Reactive oxygen species in multiple sclerosis: from source to solution
35. Baukje van der Star
Autoimmunity to neurofilament light reveals pathogenic T cell epitopes and implicates a role for CD4+
T cells in disease
36. Sovann Kaing
On the origin of proteins in Human Bruch’s membrane and Drusen
37. Karlijn Doorn
Development of a novel rat model for Parkinson’s disease
Group K: Diseases 2
Lotte Houtepen
42. Marlien Niesten
Effect of superior canal dehiscence size and location on clinical presentation, audiometric and cVEMP
testing
43. Mieke de Jager
Role of tissue transglutaminase in cross-linking of extracellular matrix proteins in cerebral amyloid
angiopathy
44. Laura Peferoen
MOG-antibodies trigger pre-active lesion formation in Multiple Sclerosis
45. Daphne Vogel
The effect of classical or alternative activation on macrophage motility in the CNS
Group M: Psychiatric disorders 1
Maik Derksen
50. Laura Koenders
Brain volume in first episode schizophrenia: a sMRI study
51. Lucija Abramovic
Global brain volume in bipolar disorder: the effects of lithium and age
52. Wanda Tempelaar
Educational level and not underachievement is related to general mental health problems in
adolescents at secondary school
53. Moran Cohn
Fear conditioning in adolescents with persistent versus desistent patterns of early-onset Disruptive
Behavior Disorders: a functional MRI study
Group O: Sensory Systems
Anke Hammerschlag
58. Andrius Plauska
The tone complex stimulation for the juxtacellular recordings in the MSO of the gerbil
59. Dyan Ramekers
Temporal response properties of the electrically stimulated auditory nerve in the deafened guinea pig
60. Daniela Camillo
Calcium imaging of contextual modulation in mouse V1
61. Marit Arp
A role of the mineralocorticoid receptor in navigational strategies
Group Q: Synapse
Lisanne Wisse
66. Margherita Farina
Proteins that control spatial and temporal release of vesicles in neurons
67. Fatima Farzana
Functional importance of neurobeachin and sap102 interaction in the synapse
68. Wendy Timmermans
Corticosteroid effects on synaptic transmission: role of Rab GTPases in AMPAR trafficking through the
endosomal pathway?
69. David Hondius
Changes in the human hippocampus proteome during Alzheimer’s disease
Group S: Networks
Martijn Kool
73. Mariette Lenselink
Towards a systems biology approach of investigating glutamatergic synapses of transgenic mouse
models of migraine
74. Rozan Vroman
Negative feedback from horizontal cells to cones induces glutamate spillover
75. Yoshiyuki Onuki
Cerebellum and hippocampus show functional connectivity during learning-dependent prediction
timing of movements
76. Jorrit Montijn
Motivation and awareness in mouse visual cortex
Group U: Behavior
Dwayne Holmes
81. Joerg Schreiber
TRIM3 is a synaptic E3 ubiquitin ligase that affects hippocampal learning
82. Maria Fernanda Vinueza Veloz
The role of motor-related brain areas in Foxp2-deficient mice
83. Marcia Spoelder
Effects of acute and repeated alcohol exposure on performance in a rat gambling task: reduced
sensitivity to punishment and behavioral disinhibition
84. Eva Naninck
Chronic early-life stress programs hippocampal neurogenesis and function: what are the responsible
molecular mechanisms?
Group W: Metabolism
Zhi Zhang
90. Judith van der Harg
Unfolded protein response (UPR) and tau phosphorylation in the brain during metabolic stress
91. Daniela Herrera Moro Chao
Iminosugars and correction of metabolic syndrome
92. Su Yan
Effects of adrenalectomy on day/night rhythms in gene expression in rat suprachiasmatic nucleus,
paraventricular nucleus of the hypothalamus and white adipose tissue
93. Hui Xiong
Hormonal Regulation of AMPA receptor function
Group Y: Modeling
Marleen van Coevorden - Hameete
98. Emmeke Aarts
Take the hierarchical road: bias due to dependency in (neuroscience) data and how to avoid it
99. Richard Hardstone
EEG correlates of resting-state cognition
100. Tafadzwa Sibindi
An optimal control model of the compensatory eye movements system
101. Bart te Lindert
Affordable sleep estimates using micro electro-mechanical systems (MEMS) accelerometry
Group AA: Plasticity 1
Esther Remmelink
106. En-qi He
Post docking role of Munc18
107. Nikhil Pandya
Structural and functional characterization of novel AMPA receptor protein: Pancortin
108. Loek van der Kallen
Regulation of hippocampal synaptic plasticity by the basic leucine zipper transcription factors CREB
and NFIL3
109. Johan Winnubst
Spontaneous network activity during development drives the clustering of temporally-related synaptic
inputs
Group AC: Electrophysiology
Sander Lindeman
114. Cillian King
Characterization of a novel synaptic E3-ligase
115. Jasper Stroeder
Shisa proteins and AMPA-receptor function
116. Borbala Duray
Neuronal oscillatory changes in an animal model of Parkinson’s disease
117. Bruno Dagnino
Attention, reward and perceptual decision making in the primary visual cortex
118. Zbigniew Zielinski
On the contributions of hippocampal ripple-associated activity to information processing in nucleus
accumbens.
Poster Session II, Friday 23 November 2012, 12:45 – 13:45
Group B: Cognition 3
Lana Beex
Hemanth Mohan
5. Irina Poslawsky
Oxytocin enhances paternal sensitivity to a child with autism: a double-blind within-subject experiment
with intranasally administered oxytocin
6. Roy Cox
The influence of sleep on the context reinstatement effect
7. Carly Sweegers
Immediate sleep leads to spontaneous recovery of a conditioned fear response
8. Devavrat Vartak
Separable effects of attention and contrast on the spread of object-based attention
Group D: Cognition 4
Kim Dekker
13. Judy Luigjes
Effective deep brain stimulation in heroin addiction: a case report with complementary intracranial
EEG
14. Annabel Vreeker
Advanced paternal age and vulnerability to psychotic-like experiences in the offspring
15. Niels Gerrits
Gray matter volume changes and cognition in Parkinson’s disease
16. Gerben Klein
The role of neural plasticity in conscious perception
Group F: Degeneration 2
Callan Attwell
21. Tatiana Cerveira
Role of Munc18 in neuronal viability
22. Ashutosh Dhingra
Patient specific induced pluripotent stem cells as a model to study Parkinson's disease
23. Chris Vriend
Depression in Parkinson’s disease is related to reduced dopamine in the caudate nucleus
24. Oscar Stassen
The role of the intermediate filament GFAP in mechanotransduction in astrocytomas
Group H: Genetics
Cátia Pereira Frias
30. Sofia Kanatsou
Mineralocorticoid receptors as genetic resilience factor under chronic stress?
31. Sietske Kevelam
Exome sequencing reveals mutated SLC19A3 in patients with a lethal, early-infantile encephalopathy
32. Peter Quinn
Manipulation of isolated müller glia cells towards discrete retinal neuronal cell fates
33. Ricardo Paap
FoxO transcription factors in control of neural stem cell fate
Group J: Diseases 3
Joyce de Wit
Premnath Thamizharasu
38. Lieke Kros
Epileptic signatures in cerebellar activity of cacna1a mutant mice
39. Eline Hamilton
Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation - study of the
phenotype and genotype and their correlation
40. Marloes Prins
CCL2 in the hippocampus of Multiple Sclerosis patients and its cuprizone model
41. Sarah Moens
The different faces of insomnia: defining insomnia subgroups
Group L: Psychiatric disorders 2
Anne Marije Kaag
46. Tanja Su
Beyond the Blood-Brain Barrier: detection of brain abnormalities in older HIV-infected individuals in the
cART era compared to matched non-infected controls
47. Suriya Navaneetha Manivannan
The dynamics of conditioned fear behavior of C57BL/6J mice in an automated home cage (Dualcage)
environment
48. Sanne van Rooij
Neural correlates of impaired response inhibition in PTSD
49. Koen van Lith
Enhancing fear conditioning in adolescents with Disruptive Behavior Disorders: a functional MRI study
Group N: Receptors
Celine Heldring
54. Marta Ruiperez Alonso
The AMPAR interacting protein Shisa-9 alters hippocampal neuronal network synchronization
55. Leanne Schmitz
The role of synaptic plasticity in reconsolidation of contextual fear memories: an optogenetics
approach.
56. Carmen Rietdijk
Enteric neurons express functional toll-like receptors
57. Marijn Schouten
Dynamics of stress hormone exposure and neural stem cell quiescence
Group P: Signaling
Niels Reinders
62. Girish Kedar
Synaptotagmin-1: involvement of the C2B domain in secretory vesicle docking
63. Arie van Vliet
Wnt5a in peripheral neuroregeneration
64. Simone Mesman
A role for Gli2A-mediated Sonic Hedgehog-signalling in midbrain development
65. Jesse Veenvliet
A homeodomain code for dopaminergic subset specification
Group R: White matter
Louise Pape
Mariska van Lier
70. Stephanie Dooves
Glial differentiation of Vanishing White Matter mutated iPS cells
71. Mohit Dubey
Astrocytic MLC1 is involved in brain water homeostasis and myelin integrity
72. Mustapha Hamada
Functional consequence of acute demyelination in layer 5 neocortical axons
Group T: Pharmacology
Linde Boekhoudt
77. Eline Zaaijer
Effect of naltrexone on striatal 123I-FP-CIT binding in rats
78. TianTian Wang
Low ambient GABA concentration in the mouse auditory brainstem in vivo
79. Iris Overwater
RATE: randomised trial of rapamycin in children with TSC and intractable epilepsy
80. Maaike Labots
Magnesium deficiency and anxiety-related behaviour of C57BL/6 mice housed under reversed
light/dark cycle conditions
Group V: Immunology
Anneloes Opperhuizen
85. Nawal Bahia el Idrissi
Complement inhibition is neuroprotective in a mouse model of leprosy
86. Melissa Lopes Pinheiro
Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial
barrier
87. Philip Nijland
Source and role of mitochondrial antioxidants in MS white matter lesions
88. Debbie Hendrickx
Selective upregulation of scavenger receptors in and around demyelinated areas in multiple sclerosis
89. Grazia Forte
Effects of rapamycin treatment on status epilepticus-induced brain inflammation and development of
epilepsy in the rat
Group X: Neuroimaging
Cheima Bouziane
Bieneke Janssen
94. Myrle Kemperman
The very late neurotoxic effects of chemotherapy in breast cancer survivors on white matter integrity
and brain function: preliminary results of a multimodality MRI study
95. Juliette Driessen
Laryngeal and hypopharyngeal carcinoma: correlation between diffusion weighted MRI and tissue
components
96. Niels Kloosterman
Neural activity in human visual cortex predicts bistable perceptual state durations
97. Judy van Hemmen
Sex hormones, sex chromosomes and sexual differentiation of the human brain
Group Z: Plasticity 2
Wobbie van den Hurk
102. Karen Carney
Identification of astrocyte-expressed proteins involved in structural plasticity
103. Anna Karataeva
Identification of protein interactors of Shisa9, a modulator of AMPAR function
104. Marc Lammers
Comparing electrically cortical potentials in pre- and postlingually deafened
105. Josta Kevenaar
Liprin-a2 regulates presynaptic plasticity by organizing active zone composition
Group AB: Neurodevelopment
Roel Mocking
110. Avanita Prabowo
Fetal brain lesions in tuberous sclerosis complex (TSC): TORC1 activation and inflammation
111. Ioannis Kramvis
GABAergic Transmission in the developing hippocampus of Fmr1-KO mice
112. Marinka Koenis
Does efficiency come with puberty? A study on structural brain network development
113. Willemieke Kouwenhoven
Homeodomain transcription factor Engrailed 1 plays a dominant role in early embryonic mid-hindbrain
patterning
Group AD: Methods
Ivana Milojevic
119. Julia Kurps
Novel image analysis tool to study the subcellular localization of secretory proteins and cortical actin in
neurosecretory cells
120. Anouk Schrantee
Investigating the 1.28ppm resonance ex vivo in neuronal progenitor cells and in vivo in rat dentate
gyrus
121. Sizar Kamar
Functional properties of photoreceptors in cultured human retina
122. Joachim Kutzera
Inferring protein-protein interaction complexes from immunoprecipitation data

 

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