Microsoft word - manuel-dtc paper.doc
Selling Prescription Drugs Directly to Consumers
Prior to 1989 prescription drug manufacturers rarely used consumer advertising, spending less than
$5 million between 1985 and 1988. The manufacturers’ reluctance was largely due to physicians, which bitterly opposed their use of consumer advertising. However, by 1996, a mere seven years later, the situation had reversed itself, as drug manufacturers spent over $790 million on the marketing, despite continued physician opposition. Over the course of those seven years physicians lost their influence vis-à-vis consumer advertising, and explaining why is the central goal of this paper. Towards that end I address four questions: (1) Why were physicians opposed to consumer advertising?; (2) Why did this opposition influence drug manufacturers prior to 1989?; (3) Why did the opposition cease to deter the drug manufacturers in the 1990’s?; (4) How did drug manufacturers work to overcome physician opposition? In the end I will argue that physician influence was diminished by two factors: 1) the Managed Care revolution circumscribed physician prescribing authority, which, in turn, weakened their influence over the drug industry, and 2) drug manufacturers studied physician opposition, which enabled them to deploy the ads in a way that was less likely to provoke physicians. Moreover, this work will contribute to the market sociology literature.
While prescription drug manufacturers1 have advertised to doctors since at least the 1930’s, their use
of consumer advertising is a recent phenomenon, for it’s only in 1985 that they first used this
marketing approach.2 Moreover, by 1989 their use of Direct-to-Consumer (DTC) ads had grown very
little, for that year drug manufacturers only spent $10 million dollars on this type of marketing (Young
& Surrusco, 2001). Today, however, drug manufacturers spend over $3.2 billion per year on this
marketing strategy (Hollon, 2005), representing a 300-fold increase since 1989.
In and of itself, such explosive advertising growth is remarkable, as it represents a complete reversal
from the previous status quo. What makes it particularly remarkable is that the ads emerged despite the
physicians’ strenuous opposition to them, opposition that had previously deterred the manufacturers
from using the ads (Lipsky & Taylor 1997, Weissman et al. 2004). Consequently, studying this
marketing revolution provides a unique opportunity to identify 1) the factors that account for sudden
shifts in marketing strategies, 2) the social forces that constrain industry from using those strategies,
and 3) how industry manages and overcomes opposition to their new marketing strategies.
To shed greater light on these issues I analyze the relationship between doctors and pharmaceutical
companies, and address four central questions: (1) Why were physicians opposed to DTC ads in the
first place?; (2) Why did this opposition influence drug manufacturers prior to 1989?; (3) Why did that
opposition cease to deter drug manufacturers in the 1990’s?; (4) How did drug manufacturers work to
overcome physician opposition? In the end I will argue that physician influence was diminished by
two factors: 1) the Managed Care revolution circumscribed physician prescribing authority, which, in
turn, weakened their influence over the drug industry, and 2) drug manufacturers studied physician
opposition, which enabled them to deploy the ads in a way that was less likely to provoke physicians.
1. "Prescription drugs" can be defined as drugs whose legal acquisition requires a doctor's prescription. Such drugs are to be differentiated from the Over-The-Counter (OTC) drugs (e.g. aspirin, cough medicine, etc.), which can be purchased without a doctor's prescription. 2. brand-name prescription drugs are to be differentiated from generic drugs, which are cheaper to produce and are far more affordable for consumers.
THE STATE OF KNOWLEDGE ABOUT DTC ADVERTISING
The rise of DTC ads has sparked vigorous debate, both in public as well as academic forums, with
much being written about the potential and realized consequences of this marketing, including how the
ads might impact 1) consumer medical knowledge (Bell et al. 2000, Kaphingst et al. 2004, Young et al.
2005), 2) the physician-patient relationship (Weissman et al. 2005, Robinson et al. 2004, Berndt 2005),
3) prescription decisions (Zachry et al. 2002, Kravitz et al. 2005, Mintzes et al. 2003), 4) prescription
drug spending (GAO 2002, Woloshin et al. 2001, Kaiser Family Foundation 2003), 5) patient safety
(Hochhauser 2005), and 6) the cost of healthcare (Rizzo 1999).
However, with all the focus given to the consequences, very little has been written about the causes
behind this marketing revolution, which is surprising when we consider the consternation the ads have
provoked in the medical community. One of two exceptions is John Abramson’s work, which
attributes the rise of DTC ads to a) the 1997 easing of Food & Drug Association (FDA) regulations,
and b) the Americans’ migration to health plans that cover prescription drug expenditures (Abramson
2004). Although Abramson’s causal explanation is an interesting one, and is worth further
investigation, there are two main problems with it: 1) he provides very little support for his claim, and
2) he posits 1997 as the watershed year in this marketing revolution, whereas drug manufacturers
began using DTC ads in 1989. While it is true that manufacturers only spent $10 million on DTC ads
in 1989, by 1996 that spending had mushroomed to $791 million (Mercola 2002), thus underscoring
The second exception has been my previous work on the issue, which demonstrated that the sudden
shift to DTC ads was driven by three market altering events, each of which strengthened generic drug
producers at the expense of brand-name drug manufacturers (Vallée 2002). Those events were: 1) the
1982 TEFRA Act, which encouraged the growth of the HMO industry, and led to the rationing of
brand name drugs, 2) the 1984 “Drug Price Competition and Patent Restoration" Act, which made it
easier to produce generic drugs, and 3) the generic drug industry’s 1985 court victory over the FDA,
which permitted generic drug manufacturers to use consumer ads for their products. In that altered
environment generic drug manufacturers had a much stronger hand, which gave brand name producers
a much stronger incentive to pursue consumer advertising.
Despite this contribution, however, the analysis was still incomplete, for while the economic
pressures began mounting in the early 1980s, and were quite significant by 1985, the brand-name drug
producers didn’t turn to DTC advertisements until 1989. Moreover, it wasn’t for a lack of interest on
their part. As one 24-year advertising veteran articulated:
"we had long wanted to go to consumer advertising… for the creative and economic benefits that it promised, but always refrained from doing so, for fear of pissing off the doctors." (interview June 1997)
Apart from reflecting the industry’s interest in DTC ads, his comment suggests that physicians were
strongly opposed to this form of marketing, and, importantly, the drug manufacturers knew it and
respected it.3 This underscores that DTC advertising didn’t emerge unopposed, and that many agents
had a stake in opposing the use of this advertising. Along these lines, one could also point to regulatory
agencies4 and HMO bureaucrats5 as other agents who opposed DTC ads. Doctors, though, are
particularly important to this story, for, ever since the emergence of prescription drugs, they have been
the gatekeepers between drug manufacturers and the consumer market, a fact drug manufacturers
3. Some might argue that the FDA's deterrence effect was just as important, citing the lack of DTC ads during the FDA's
mid-1980s moratorium on prescription drug consumer advertising. However, such an argument would be unsatisfactory for
two reasons. First, prior to the moratorium, in 1983, there were no governmental regulations prohibiting the DTC ads, yet
manufacturers refrained using such marketing. This suggests that manufacturer behavior was influenced by other agents
with power. Second, after the moratorium was lifted, in 1985, brand-name manufacturers refrained from using the ads until
1989, thereby also suggesting that manufacturers were being deterred by another source of power. Consequently, while the
FDA's moratorium may have slowed the manufacturers' movement towards consumer advertising, it is the physicians'
opposition that served as the primary deterrence. 4. For instance, the FDA’s monitoring of the pharmaceutical industry has been made more difficult by the additional responsibility of having to monitor and regulate consumer advertising, a task for which they are understaffed, and underfunded.
recognized and respected.6 With that said, something changed in 1989, as physician opposition ceased
to be an effective deterrence against consumer advertising. Shedding light on why will be this paper’s
For theoretical insight on these developments I turned to Paul Starr’s The Social Transformation of
, which illuminated the 150 year relationship between physicians and drug
manufacturers (Starr 1982). Starr showed that 19th century drug manufacturers openly competed
against physicians, using consumer ads that explicitly denigrated the medical profession. As well, he
specified how the medical profession got even with the drug industry in the early 1900s. More
specifically, during the second half of the 19th century medical profession leaders sought to improve
the profession, and over time their efforts led to greater scientific credibility, prestige, wealth, and
political power. In turn, the profession’s newly acquired muscle gave them the power to rein in the
drug manufacturers’ marketing activities, leading the drug producers to abandon their use of consumer
advertising. Given this history, it stands to reason that if greater organizing enabled physicians to
stamp out the original consumer ads, the loss of such organizational power would help explain why
physicians ceased being a deterrence in the late 1980s. This is the main theoretical proposition that this
paper will engage with, and I will return to it in the concluding chapter.
The core of this paper is divided into four sections. The first analyzes the physician opposition, and
elucidates the real concerns they had with DTC ads, while the second explains why drug
manufacturers previously respected physician opposition to. The third section focuses on a) the
medical bureaucrats’ growth in power, b) how that growth in power circumscribed the physicians’
ability to prescribe, and c) how the physicians’ circumscribed power diminished their leverage vis-à-
vis the drug manufacturers. And the fourth section will demonstrate how drug manufacturers worked
5 . The medical bureaucrats’ opposition to DTC ads dates back to 1983, when passage of the TEFRA act gave them far greater incentive to ration medical resources, and reduce the use of expensive resources, such as brand-name prescription drugs. 6. A significant part of the advertiser’s mission is shaping how physicians perceive drug manufacturers and their products, for industry research has demonstrated that while physicians like to posit themselves as making purely ‘rational’ decisions, the truth is far different,
to defuse and control the physicians’ opposition. In the concluding section I will tease out how the
implications of this case for our understanding of A) the likelihood that drug manufacturers will used
DTC ads in other countries, B) the source of physician power, and C) the sociology of markets
THE PHYSICIAN OPPOSITION TO CONSUMER ADVERTISING
1) The Source of Physician Opposition
Why were physicians opposed to consumer advertising? In order to answer that question it is
essential to understand the physician concerns with consumer advertising. Moreover, we can shed light
on the issue by examining the letters that medical associations sent to the FDA, during the agency's
1983-85 moratorium on consumer advertising.
The overarching concern emerging from those letters is that DTC ads would confuse patients,
because they were destined to make overly general claims, and omit pertinent information about side
effects and contraindications.7 In addition, presuming the ads provided all the necessary information,
physicians believed that patients lacked the capacity to properly understand the medical information
In turn, physicians feared that such confusion would impact healthcare in three ways. First, the
ensuing confusion would frighten the patient, and delay them from seeking medical attention. Second,
the ads would lead consumers to pressure doctors into prescribing advertised products when such
products were inappropriate, or were an inferior treatment option (ibid.). And third, the confusion from
the ads would reduce the amount of time dedicated to addressing the patient’s illnesses, as doctors
would have to spend time correcting the misinformation that patients absorbed from the ads. Not only
with emotional factors playing a significant role in physician prescription decisions. Thus, the advertisers try to avoid doing things that could lead physicians to see the drug manufacturer in a negative light.
would they have to correct the misinformed patient, physicians would also be obliged to explain why
advertisements were not a viable source of medical information, thus further reducing the amount of
time dedicated to the patient illnesses (ibid.).
While the FDA letters communicated the medical profession's concern for their patients, they fail to
divulge the physicians' vested interests vis-à-vis DTC advertising. For instance, the letters fail to
communicate that disseminating information to consumers would erode the physician monopoly over
medical-knowledge, which would weaken both their "cultural authority"8, and their control over the
physician-patient relationship. This is not an idle point, for Paul Starr found that the power of
American physicians was founded on the profession’s ability to monopolize medical knowledge in the
1910s & 1920s, which, ironically enough, was achieved by compelling drug manufacturers to restrain
from advertising directly to consumers (Starr, 1982).
Moreover, the FDA letters also failed to disclose the physician concern that such a loss of authority
could drive a wedge between themselves and some of their clients, thereby impacting their livelihood.
More specifically, many physicians feared that consumer advertising would lead patients to arrive at
the clinical encounter with expectations of getting a specific medication, and predisposed to taking
their business elsewhere if the physician didn't comply. Such concerns are exemplified with the
"one morning this month, Dr. Michael Buenaflor, a family practitioner in Northampton, PA.,
took a call from a patient who wanted a prescription. And not just any prescription. The caller insisted on Nicorette, a drug intended to help people stop smoking. How did he find out about it? From an advertisement. When Buenaflor suggested that the drug might not be appropriate for prolonged use, since the patient had a heart condition and an ulcer, the man hung up and took his 'business' elsewhere. Concludes Buenaflor: 'The pressure to use these drugs is incredible.' "(Purvis 1990)
7. "Contraindications" refers to conditions under which the patient should not be taking a particular drug. These can include having a certain illness, or be undergoing another medical therapy, such as other pharmaceutical medications. 8. In The Social Transformation of American Medicine
Paul Starr argued that the physicians’ success at monopolizing medical knowledge is what enabled them to accrue their “cultural authority” that physicians were able to consolidate their "cultural authority" because they successfully monopolized medical knowledge, which was partially accomplished by diminishing the amount of information that drug manufacturers disseminated to consumers (p. 128-133).
Similar episodes emerged during physician interviews, with one physician relating how he lost a client
due to his unwillingness to prescribe Sporanox, a medication designed to eliminate toe-nail fungus.
"a few months ago one of my long-time patients called me, asking me to prescribe Sporanox.
However, I refused because that drug was contraindicated with the pharmaceuticals he was already taking. Unfortunately, he wasn't ready to take 'no' for an answer, and spent the next 15 minutes trying to change my mind… Having failed to do so, he hung up in a huff and I haven't heard from him since." (Interview Nov. 1997)
Such episodes suggest that physicians were justified in being concerned about the ads, both for their
impact on physician interests, as well as patient well-being. What I now turn to is addressing how the
physician opposition manifested itself over time, as well as why such opposition deterred the drug
manufacturers from using DTC advertising.
2) The Source of Physician Power
Why was physician opposition previously a deterrence to DTC ads? In order to answer that question
we need to historicize the relationship between drug manufacturers and physicians, for the struggle
over consumer advertising stretches back to the mid 19th century, and tracing that struggle will
illuminate why the balance of power changed at the end of the 20th century.
Ever since its inception, in 1844, the American Medical Association (AMA) opposed consumer ads
for pharmaceutical products, because drug manufacturers were competing directly with physicians, and
their ads explicitly denigrated the medical profession. The medical profession’s first organized
response to the ads occurred in 1849, when the AMA attempted, unsuccessfully, to establish a council
dedicated to regulating the drug industry (Starr 1982). In the ensuing decades the AMA pursued
several other efforts to rein in drug advertising, but the AMA always lacked the financial resources
By 1900, however, the situation began to change. The medical profession, thanks to the AMA’s
efforts, had finally achieved a high degree of professional unity, which enabled the AMA to accrue
tremendous financial resources. With such resources in hand, the AMA took another stab at regulating
the advertising, asking medical journals to reject all advertisements that were either A) marketed to the
public, or B) whose ingredients weren’t disclosed to the public. Although that request fell on deaf ears,
they tried again in 1905 and succeeded, as the profession's leading medical journal (e.g. The Journal of
the AMA (JAMA)) took the editorial decision to reject all ad submissions for products that were also
advertised to consumers. Other medical journals quickly followed JAMA’s lead, and effectively forced
drug manufacturers to choose between marketing their products to consumers or to physicians. Given
physicians’ growing medical authority, the drug manufacturers were left with little real choice in the
matter. Furthermore, in 1924 the medical profession strengthened its assault against consumer
advertising, as JAMA extended its advertising policy to exclude all drug companies who used
consumer advertising for any product (Starr 1982). From this point onwards, drug manufacturers had
to decide to either dedicate themselves entirely to the consumer market or to the medical profession,
with the majority choosing the latter. The self-imposed ban on consumer ads even persisted during the
1950s, the Golden age of pharmaceuticals, when drug manufacturers made one discovery after another,
and had millions to spend on advertising.
However, in the early 1980s something changed, as manufacturers openly expressed their interest
in consumer ads, which, in turn, prompted physicians to re-manifest their opposition to the marketing.
In particular, the opposition manifested itself during the FDA public discussions on DTC advertising 9,
held between 1983-85, where numerous medical associations (including the American Medical
Association, the American Society of Internal Medicine, The American Academy of Family
Physicians, and the American Academy of Ophthalmology) voiced their explicit opposition to all
9. The FDA organized these discussions in conjunction with their 1983-85 moratorium on consumer advertising, and their main purpose was to identify the consequences that might follow the legalization of DTC ads, as well as predict their potential impact on healthcare.
prescription drug consumer advertising (US Gov. 1984). A decade later physician opposition was still
alive and well, as as 80% of surveyed physicians believed the ads were a bad idea, citing that such ads
lead to increased costs and promote "misleading, and biased views" of prescription drugs (Lipsky et
al., 1998). As well, such opposition manifested itself in the physician interviews I conducted, as the
physicians complained that the ads a) undermined their authority, b) strained their relations with
patients, and c) led consumers to pursue treatments that were either inappropriate, or dangerous for
their given condition (interview April 1997).
Thus, we see that physicians were explicitly opposed to DTC ads, and that the opposition
maintained itself right through the 1990s. However, despite the unyielding opposition, drug
manufacturers pursued consumer advertising, which suggests that physicians lost their power to deter.
Accounting for why that happened is what we now turn to.
3) The Managed Care Revolution and the Physician Loss of Power
The Managed Care revolution had a profound effect on the physicians’ power, for the revolution
gave medical bureaucrats a growing incentive to cut medical costs, thereby encouraging them to play a
larger role in prescription decisions. As this pertains to prescription drugs, the bureaucrats sought to
limit prescriptions via four different tactics. First, bureaucrats prohibited hospital pharmacies from
carrying the costliest drugs, which left physicians with little choice but to either prescribe generic
equivalents, or prescribe the cheaper brand-name drugs that had similar therapeutic effects. A second
tactic was to institute "generic substitution" practices, whereby HMO and hospital pharmacists were
required to fill prescriptions with the generic version of a drug, even when physicians had specifically
prescribed the more expensive brand-name version (American College Physicians, 1990). Third,
bureaucrats instituted "therapeutic substitution" practices, whereby prescriptions for expensive brand-
name drugs are automatically filled with drugs that differ in chemical composition, but are cheaper,
and are believed to have the same therapeutic effect (ibid.). Although this tactic faced strong
opposition from medical associations (Meyer 1987), by 1990 therapeutic substitution was occurring in
"more than 52% of the nation's acute care hospitals and more than 30% of health maintenance
organizations" (American College Physicians, 1990).
The fourth bureaucratic tactic was to formalize the physicians' decision-making process, by
implementing "step-care protocols." These protocols require physicians to prescribe less expensive
drugs for initial office visits, and to only prescribe costlier drugs if the patient returns with the same
ailments. For example, the first time a patient complains to his doctor about abdominal pains, the
doctor is to prescribe an inexpensive Over-The-Counter (OTC) pain-killer (such as Tylenol, Ibuprofen
or Advil). If the patient returns with the same symptoms, the doctor is authorized to prescribe a
generic prescription drug. If the patient returns for a third visit, the doctor can prescribe an inexpensive
brand-name prescription medicine, such as Rodixin. If the patient comes back for a fourth visit, then,
and only then, is the doctor authorized to prescribe the strongest, and costliest, drug Naprosyn
(interview May 1997). Even if the doctor knows from the beginning that Naprosyn is needed, their
hands are tied until they can prove, to medical bureaucrats, that the less expensive medicines have
Consequently, the step-care protocol reduced the flow of expensive drugs in four ways. First,
consuming over-the-counter pain-killers was sufficient to heal some patients (whether due to organic
reasons or the placebo effect), who otherwise would have received Naprosyn. Second, prescribing an
inexpensive prescription drug, in the second visit, also led to healing efficacy in some patients, thereby
also reducing Naprosyn sales. Third, even if the first two drugs were not efficacious, the patient might
not present him/herself for a third visit, due to either frustration and/or the loss of faith in drugs, their
doctor, and/or the medical system. Fourth, because the Managed Care prescribing process imposes a
greater delay between the initial symptoms and a potential Naprosyn prescription, it is possible that the
patient's body will have healed itself before Naprosyn ever gets prescribed. Each of these scenarios
plays a role in diminishing the number of patients who will purchase Naprosyn, thus diverting money
By implementing their four tactics medical bureaucrats effectively circumscribed the physicians’
prescribing authority, and achieved their goal of reducing prescription drug expenditures. Importantly,
this weakened the drug manufacturers’ ability to drive drug demand through physicians, and gave them
a much greater incentive to drive demand through consumers. At the same time, however,
manufacturers didn’t rush out to use consumer ads, and that’s because they knew that physicians still
had to sign off on every prescription. If they were to use DTC advertising, they had to do so very
carefully, deploying the ads in a way that was unlikely to antagonize physicians. Towards that end
manufacturers began studying the physician opposition to consumer advertising, which is what I now
4) Managing Physician Opposition to DTC ads
When it became clear that physicians were opposed to DTC ads, drug manufacturers turned to
studying that opposition, in order to better understand it, and defuse it. Towards that end, their
researchers studies four aspects of the opposition, including 1) the variance in opposition from one
physician to the next, 2) the general concerns physicians had vis-à-vis consumer advertising, 3) how
physicians were likely to react to specific ad campaigns, and 4) how specific DTC ad campaigns
impacted prescribing behavior. In what follows I will elucidate each of these four discoveries, and
show how the knowledge helped manufacturers to deploy consumer advertising in a way that was less
likely to provoke the medical profession.
4.1) The First Set of Findings – Varying Levels of Physician Opposition
Although the medical profession often presents a united front to the public, physicians actually differ
significantly on a whole host of issues. This is amply demonstrated in the JAMA’s "Letters to the
Editor" section, where diverging opinions are voiced on a variety of topics. Importantly, drug company
researchers are well aware of this variance, and accounting for it has become an important strategy in
devising effective physician-targeted advertising campaigns.
Unsurprisingly, the physician opposition to DTC ads wasn’t as complete as it first appeared, and that
variance was one of the first things drug company researchers tried to study. Although most
advertising research is proprietary and therefore inaccessible by the public, one exception is the work
carried out by Petroshius and colleagues. In the early 1990s these marketing researchers studied the
relationship between physician characteristics (such as medical specialty, age, number of years in
practice, etc.) and physician attitudes towards consumer ads (1995). In particular, they had drug
company representatives hand-deliver questionnaire surveys to the physicians, with the surveys
probing the doctors about their personal characteristics, as well as their attitudes towards consumer
advertising. In turn, their research identified significant fault lines within the profession, with
physician opposition being weaker among physicians who a) had fewer years of experience, b) were
younger, c) practiced a specialty other than internal medicine, d) practiced in urban settings (as
opposed to rural ones), and e) practiced in group practices (as opposed to private practice).
Identifying that variation served the pharmaceutical manufacturers in two inter-related ways. First, it
allowed the manufacturers to identify the physicians who had the weakest opposition to consumer ads.
Such data has parallels with army reconnaissance reports, as it enabled manufacturers to identify the
weaknesses in physician opposition, and to deploy the ads precisely where opposition was weakest. At
the beginning, physician opposition was weakest among dermatologists, and, not surprisingly, the first
extensive use of the ads was for Rogaine, the anti-balding medication that was mostly prescribed by
Second, the research findings enabled manufacturers to identify the physicians who had the strongest
opposition to consumer advertising. This allowed them to avoid using the advertising for drugs that
those physicians were most likely to prescribe. For instance, early on it was the internists who had the
strongest opposition to DTC ads, and such ads were not initially used for the drugs prescribed by those
specialists (such as drugs for heart attacks, high cholesterol, etc.). In fact, manufactures did not use
DTC ads for those products until August 1994, which was after the marketing tactic had been
successfully deployed for anti-balding medication, anti-allergy medications, and anti-smoking
4.2) The 2nd Set of Findings – The Physicians’ General Concerns with DTC Ads
The second insight manufacturers gained was a better understanding about the physicians’ general
concerns with consumer advertising. More specifically, they found that physicians were concerned
with two overarching issues: 1) the impact of the ads on physician relationships with patients, and 2)
their impact on patient well-being. Knowing these concerns informed manufacturers about how their
use of the ads might exacerbate physician ire, thereby enabling them to craft consumer ads that
respected the physicians' concerns, and, thus, reduced the chances of triggering a physician reaction.
Regarding the patient/physician relationship, physicians had two concerns, with one being that the
proliferation of the ads would prompt patients to ask more questions in the medical encounter.
Although physicians did not necessarily perceive this as a threat to their medical authority, many
perceived that the question-answering would be a nuisance, which would burn valuable clinical time
and reduce the number of patients that they could see in a day (Oct. & Nov. interviews 1997, Purvis
A second, and more important, physician concern was that consumer advertising would lead patients
to self-diagnose their own symptoms, thereby fostering expectations to get the advertised product from
their doctor. Physicians believed that such expectations would increase patient assertiveness in the
clinical encounter, thereby undermining the physician's medical authority. In turn, the ensuing
confrontation would obligate the physician to spend valuable time explaining why the advertised
product was not suitable for that patient's case, while also explaining why advertisements were not a
reliable source of medical information. An even more dire possibility was that the patient's increased
assertiveness would threaten the patient-physician relationship, leading patients to lose faith in their
physician, and to seek one who was more amenable to prescribing the desired drug product, as was
However, knowing this physician concern enabled manufacturers to craft consumer ads that
minimized the threat to physician authority. In the beginning (eg 1985 to 1988) this meant restricting
themselves to ‘public service’ ads, an advertising strategy that ostensibly ‘educated’ consumers about a
specific disease, without referring to any drug product.10 An example of such ads is the 'anti-balding'
advertisement found on the next page. As is demonstrated in that example, while "Upjohn" is clearly
identified as the ad sponsor, no mention is made of any 'anti-balding' medication, even though Upjohn
was the manufacturer of Rogaine, the leading anti-balding medication of the era. As well, the ad
doesn’t even mention that pharmaceutical medicines are a potential treatment for 'hair-loss'. Instead,
the emphasis is on informing consumers that A) hair loss can be treated, and that B) they should
consult their physicians about such treatments. With this marketing strategy manufacturers were able
to stimulate consumer interest for hair-loss treatments11 without providing information that could
undermine the physicians' medical authority, or antagonize them.
The second phase of consumer advertising began in 1989, when the manufacturers started deploying
ads that not only mentioned specific drug products, but made bold medical claims about those
products. Such advertising was much more likely to raise the physicians ire. However, such a risk was
tempered by the fact that prior to using claim-making ads, manufacturers invariably used less
10 . Though it’s worth mentioning that the only manufacturers who used these ads were the ones who had drugs on the market, and could
thus benefit from increasing consumer awareness about the condition. This was particularly true of those who had the top selling products. 11. It bears mentioning that since Rogaine was the top selling product of its class, Upjohn stood to gain the most from informing consumers that that hair-loss could be treated.
provocative ad formats, which included 'public service' ads, “Brand Awareness ads”12, or “Brand-
Comparison” ads13. As TABLE 1 demonstrates, out of the 20 product types14 advertised, 15 of them
were first advertised via one of the more palatable advertising forms. Moreover, it wasn’t until
November of 1993 that any product began to be advertised with claim-making ads. Thus, the data
indicates that manufacturers deployed the advertising conservatively and incrementally.
TABLE 1 - The Gradual Progression Towards Claim-Making Ads *
1st Use of Public 1st use of Brand 1st use of Brand
Awareness Ads Comparison Ads Claim-Making Ads
12. “Brand-Awareness” ads are advertisements that promote a product, and make implicit suggestions about what the drug’s use may be, without making any explicit claims about the drug. Because the ads weren’t making specific claims about the drugs, physicians were less likely to feel that manufacturers were encroaching on their turf. An additional benefit is that the lack of product claims meant the ads didn’t require FDA approval. An example of this ad genre would be the ads produced for Nicorette gum (e.g. the smoking-cessation product), which made no medical claims, but whose function was implied by the product’s name. 13. Product-comparison ads compare the promoted product to another product, but without providing medical information on either product, thereby also preserving the physician's monopoly over medical information, while also escaping the FDA scalpel.
14. This only includes the drugs that were the first in their class to be advertised via consumer advertising, for once a drug had been advertised successfully to the consumers, the ice was broken for all the products in its class. For example, after Seldane’s (eg an allergy-
relief medicine) manufacturer was able to successfully use consumer advertising, consumer ads were used for the other allergy relief
medications, including Flonase, Allegra, Claritin, Hismanal.
* : Based on a survey of all TIME Magazines from Jan. 1989 to Jan. 1998
*** : This category includes prescription medications to treat hair-loss, dandruff, psoriasis, toe fungus, &
When manufacturers did proceed to claim-making ads, they still did so with caution, and heeded the
physician concerns about this marketing form. A particular physician concern was that patients might
arrive in the clinical encounter knowing more than the physician about a particular drug product
(interview 1997), for if that would occur, it would place the physician at a disadvantageous position,
which could undermine their medical authority. Such a concern seems well warranted for Edward
Shorter found that patients of the late 20th century expect their doctors to be on the cutting edge of
medical knowledge, and when they aren’t, they lose both their “scientific credibility”15, (Shorter 1991)
and the control over the patient-doctor relationship. Consequently, the advertising agencies who knew
about this concern made a point of only informing consumers about a drug after they had informed
physicians about it, either through medical journal advertising, Continuing Medical Education (CME)
conferences, or sales visits from pharmaceutical marketing representatives. In turn, timing the use of
consumer advertising in this way diminished the chances that a patient would catch a physician flat-
footed, thereby decreasing the chances of provoking physician resentment vis-à-vis the use of
Beyond the timing of ad deployment, manufacturers also paid attention to physician concerns about
ad copy. As one advertising executive revealed, “in deploying these new ads we (e.g. manufacturers &
their advertising agencies) knew that physicians were still concerned that the advertisements would
weaken their medical authority, and so we made sure to always word the ads in a way that would
explicitly affirm physicians' authority.” Examples of such a practice included: "Ask Your Doctor if
this Product is Appropriate for You", as well as, "Only Your Doctor Knows if This Medication is
15 Steven Epstein defines “scientific credibility” as that which gives a person the power to pronounce authoritatively on a disease and its treatment (Epstein, 1995).
Appropriate for Your Symptoms." All of this underscores the point that manufacturers deployed DTC
ads conservatively and incrementally. In turn, this deployment pattern helped ease the physicians into a
new marketing culture, one where DTC ads were growing increasingly ubiquitous, and were
increasingly directing patients to the doctor.
4.3) Studying Physician Reactions to Specific DTC Ads
Beyond studying physician opposition as an abstract concept, manufacturers also studied physician
opposition to specific consumer ads, doing so through their drug representatives and the use of focus
Drug representatives (also called detail men and detail women) visit doctors on a monthly to bi-
weekly basis, and while their main objective is to "educate" physicians on the company's drug
products, their interpersonal contact with physicians makes them privy to solicited and unsolicited
feedback about the company's products and/or behavior. Consequently, if physicians were upset with a
company's use of consumer advertising, the company's sales reps were likely to detect that
dissatisfaction, and report it back to the company. In turn, the marketing department would use this
information to adjust the advertising, so that they were less likely to antagonize physicians.
A second, and more systematic, way to elicit feedback has been through ad pre-testing, which
marketers accomplished through focus group research and/or one-on-one interviews. To carry out this
research, marketers recruit the medical specialists who are most likely to prescribe the drug in question
(interview July 1997). For example, if the product is a cosmetic drug, then dermatologists will be
selected for the research. If the drug targets cancer, oncologists will be chosen. If the drug addresses
psychiatric issues, psychiatrists will be recruited, and so on. In building their sample, marketers were
concerned about generalizing from too small a population pool, and so enticed physician participation
by offering healthy honorariums (ranging from $250 to $1000 per physician, per session), as well as
fancy meals (Stolberg et al., 2000). The marketers were also concerned about regional idiosyncracy,
and so often pre-tested the ads in different regions of the country.
After the recruitment of the physicians, the next step was to elicit their responses to the ads. Towards
that end, marketers presented the physicians with trial versions of an ad campaign, and requested their
feedback on the individual components of each ad. The components that were tested included
headlines, ad copy, photographs used, colors used, and even the placement of each component. With
such feedback in hand, marketers were able to isolate the elements of an ad that were likely to offend
or disturb physicians, before the advertising launch. In turn, this enabled them to change the ads, and
reduced the risk of angering physicians.
This process is exemplified by a local advertising agency, which pre-tested consumer ads for a
Multiple Sclerosis drug. For this product the ad agency recruited numerous neurologists (the medical
specialists identified as the most likely to prescribe the drug), who offered valuable feedback on the ad.
One particularly salient feedback pertained to the ad's headline, for, one after another, physicians
expressed discomfort (which ranged from medium to serious) with the headline "Are You Losing
Your Mind?". The neurologists felt that such a headline was inappropriate in addressing the sufferers
of Multiple Sclerosis, for it was likely to exacerbate the patients’ anxieties. Consequently, the
feedback led the agency to change the headline to “Are you experiencing performance issues?,” a
headline that physicians found much more palatable, and which drastically diminished the odds of a
physician backlash against either the ad, and/or the drug manufacturer who deployed it.16
4.4) Monitoring the Physicians’ Prescribing Behavior
16. Another benefit derived from the interviews is that they informed advertisers about the interaction between doctors and patient,
information that the agencies used to strengthen their advertising efforts. Specifically, some advertising executives discovered that when
doctors and patients discuss particular drug options, physicians tend to discredit ads as a viable source of information and direct patients to acquire knowledge from magazine articles and/or editorials. Subsequently, this led to the manufacturers’ deployment of advertorials,
veiled advertisements that take the guise of unbiased editorials. This veiled advertisement is used to inform the reader about a specific
medical condition, and to recommend a specific drug therapy for the illness, a therapy that happens to be a drug product of the advertorial’s sponsor. Then, a few pages later, the message is reinforced with a full-blown ad for the same sponsor's medical product.
After an ad has been pre-tested the next step is to launch it and monitor its effects on prescribing
behavior. Previously drug manufacturers pursued such monitoring through their sales reps, who would
report on physician reactions to both new drug products and the manufacturer’s marketing behavior.
However, in the early 1990s the manufacturers’ surveillance power became considerably stronger, due
to tremendous advances in computer technology. More specifically, as computers became faster and
cheaper, medical organizations (such as the AMA) turned to computerizing their databases, which
made it more accessible to pharmaceutical manufacturers and/or their advertising lackey.
Particularly salient to this story are the pharmacies, the American Medical Association (AMA), and
the Drug Enforcement Agency (DEA), for each of them compile information on the physicians, which
they sell to pharmaceutical companies (Stolberg et al., 2000). Pharmacists, in particular, compile and
sell information on each prescription they fill, information that enables the drug company to
"identify the highest and lowest prescribers of a particular medicine in a single ZIP code, county
state or the entire country. They can learn, for example, which antidepressants a particular psychiatrist favors" (Stolberg et al., 2000)
Although the pharmacy records don't identify physicians by name, it does identify their DEA code
(which the DEA issues to each doctor in order to track controlled substances). Moreover, this code is
matched with physician names in the AMA physician database, which contains a personal biography
for every doctor practicing in the United States, and which the AMA routinely sells to drug
manufacturers.17 Consequently, the access to these databases enables manufacturers to link individual
physicians with their prescribing behaviors, thereby granting them an effective way to measure
marketing efficacy, whether the marketing is consumer advertising or physician-targeted marketing.
For consumer advertising this was particularly important, for tracking the prescribing behavior enabled
manufacturers to detect the negative reactions that physicians might be having to consumer
advertising, information that would help them 1) track down the cause of the reaction, and 2) adjust the
17. The AMA biographies also provide information about each physician’s academic and personal interests, which manufacturers use to determine how they will attempt to influence specific physicians.
The medical profession has long opposed the drug manufacturers’ use of consumer advertising, and,
for most of the 20th century, that opposition deterred manufacturers from using the ads. However, that
ceased to be true in the early 1990s, and uncovering why has been this paper’s central goal. Towards
that goal, I have identified four contributing factors, with the first being the rise of HMOs, and their
cost-cutting approach to healthcare. This event had effectively circumscribed the physicians’
prescribing power, and weakened their leverage vis-à-vis the pharmaceutical companies. Secondly, the
drug manufacturers actively studied the medical profession, so as to a) better understand the
physicians’ general concerns about consumer advertising, and b) use that knowledge to create ads that
were less likely to provoke the medical profession. Third, prior to launching particular ads the
manufacturer would test the ads in physician focus groups, so as to, again, identify and avoid any
element that might provoke a negative reaction. And fourth, after deploying the ads, manufacturers
monitored physician prescribing practices, so as to ensure that the consumer ads didn’t negatively
affect physician prescribing behavior, and/or their perceptions of the manufacturers.
THE FUTURE OF DTC ADS IN AMERICA
Now that the genie is out of the bottle, it is doubtful that the situation will reverse itself. What seems
particularly certain is that there is little that the medical profession can do about it, for now that the
profession has allowed itself to be studied, the manufacturers know exactly how to manage the
physicians’ opposition. Moreover, there is nothing the profession can do to retract that knowledge. In
addition, it seems the physicians’ powerlessness will only grow, for those with the greatest resistance
to DTC ads were physicians of the pre-DTC era. As those physicians cycle out of the profession, the
professional resistance to the ads will continue to diminish.
While physicians are unlikely to bring about change, change might emerge from consumers, and this
for two reasons. First, the recent prescription drug scandals (such as those relating to VIOXX & the
prescription of anti-depressants to kids (Harris 2004)) might prompt consumers to realize the extreme
dangers associated with prescription drugs, which, in turn, might lead them to pressure the FDA into
strengthening regulations around the marketing of prescription drugs. Secondly, consumers might be
prompted to act by the growing healthcare expenditures. More specifically, as the marketing continues
to drive up medical expenses, consumers might start thinking twice about always demanding the latest
and most expensive medication, opting instead for older generation drugs that are just as effective, but
cheaper. This would diminish the effectiveness of consumer advertising, and potentially prompt the
manufacturers to use different marketing strategies. However, for either of these possibilities to occur,
American consumers would have to become more savvy about drug industry marketing, as well as far
DTC ADVERTISING IN THE REST OF THE WORLD
As of June 2007, New Zealand was the only other country that permitted consumer advertising for
prescription drugs. However, that permission might be withdrawn, as the country’s health minister
recently concluded that the potential benefits of the marketing do not justify the harms, and discussed
plans to end it (Mansfield 2005). That political fight is one well-worth watching, as it might provide
valuable insight on how consumer advertising could be retracted from the American scene.
Elsewhere, in 2004 the Canadian parliamentary inquiry “recommended against direct to consumer
advertising because ‘Drug advertisements could endanger rather than empower consumers by
minimizing risk information and exaggerating benefits’ and ‘could contribute to increased or
inappropriate drug consumption’”(ibid.). This development is of debatable consequence, however, for
while the ads haven’t been legalized in Canada, Canadians are, in fact, exposed to them every day, via
their consumption of American media, which includes television programming, newspapers and
magazines. Moreover, there doesn’t seem to be anything that can be done about this situation,
effectively linking the plight of Canadians with that of the Americans.
While the Canadian and New Zealand cases are interesting in their own right, drug manufacturers are
undoubtedly more interested in the European case, for if they can get their way with the European
Union (EU) bureaucracy, manufacturers could target their ads at over 450 million consumers.
However, the manufacturers attempts have been rebuffed thus far, for in 2003 the EU Health Ministers
rejected the proposal to legalize a limited use of DTC ads (Watson 2003). Undoubtedly, the drug
manufacturers will persist in their lobbying efforts, and should they succeed, the deployment of the ads
will vary from country to country, a variance that will be mediated by three overarching factors: 1) the
economic pressure on drug manufacturers, 2) consumer receptivity to the advertising, and 3) the
medical profession’s resistance to the advertising.
Regarding the economic pressures, in the United States the pressures came primarily from the
emergence of “Managed Care”, where medical bureaucrats placed increasing importance on the cost-
benefit analysis of treatments. This shift, in turn, benefited the generic drug manufacturers, thereby
increasing the pressure on brand name drug manufacturers (Vallee 2002). While similar economic
pressures might arise in Europe, economic pressures could also arise from other sources, such as
tougher drug approval regulations, and/or the growing use of alternative medicines.
If such economic pressures emerge, the second necessary factor will be consumer receptivity. In
order for consumer ads to work, they will need to be targeted at a population that is 1) predisposed to
receive and integrate medical knowledge, and 2) predisposed to use medical knowledge in the clinical
encounter. These characteristics were present among the Americans of the late 20th century(Vallee
1999), and this explains why the drug consumer advertising has been so successful in America.
Assuming the consumer factor is met, the third factor mediating the use of the ads would be the
resistance of that country’s medical profession to such marketing, along with the drug manufacturers’
ability to manage that resistance. As demonstrated in this paper, the manufacturers’ ability to use
consumer advertising in the U.S. was mediated by the role played by the AMA and individual
physicians, who willingly helped drug manufacturers study and better understand the physicians’
THE THEORETICAL CONTRIBUTIONS TO THE STUDY OF MARKETS
This case study makes five theoretical contributions to the study of markets. First, it demonstrates
that governments aren’t the only entities that limit industry conduct. While Fligstein (2001) posited
that governments play a central role in controlling industry behavior, here we saw that physicians also
significantly influenced the pharmaceutical industry. Consequently, future research on markets should
pay close attention to the way that non-governmental actors shape the marketing behavior of other
industries. For instance, which non-governmental actors influence the marketing behavior of toy
manufacturers, record companies, or food manufacturers? The range of behavior in each of those
industries is influenced by more than just government regulations, and greater attention to those
influences will give us a more comprehensive understanding of marketing behavior.
Secondly, the analysis revealed that the influence of non-governmental actors changes over time.
More specifically, while the physicians’ deterrence effect was nearly non-existent in the 1850s, by the
1920s it had become dominating, only to weaken again in the late 1980s. Thus, it behooves us to avoid
reifying the deterrence effect of any particular actor, and view the deterrence effect as being dynamic
Third, we saw that the change in deterrence effect was mediated by a number of different factors,
including those that were intrinsic to the medical profession. More specifically, the profession’s
original power, vis-à-vis drug companies, was the result of 19th century organizing activities, which
consolidated the profession, and strengthened its unity, credibility, prestige, wealth and political
power. Their unanimous unity against consumer ads, in the 1920’s, seems to have been particularly
important, for its absence in the 1980s significantly undermined their leverage over the drug
Fourth, I showed that another factor mediating the deterrence effect is the industry’s work to manage
or defuse it. In their pursuit of consumer advertising, the drug manufacturers actively studied the
physicians’ opposition, so as to understand how to skirt and defuse it. Thus, future research should
study the way that industry tries to identify and defuse the opposition to its marketing activities.
Fifth, we saw that the deterrence effect was also mediated by the economic context. More
specifically, while the physicians held a lot of leverage during most of the 20th century, that leverage
was diminished by the healthcare inflation, which brought on the HMO industry, and the curtailing of
physician prescribing authority. Thus, in trying to understand why an actor’s influence changes over
time, it’s vitally important to place the change within its economic context.
APPENDIX 1 - Methods
In pursuing this project I relied on four types of data: 1) secondary sources, 2) congressional
records, 3) interviews, and 4) consumer ads appearing in the print media.
The secondary sources consisted of mainstream and academic articles published on the issue. For
the latter I conducted article searches in Pubmed and JSTOR, using “DTC ads”, “DTC
advertisements”, “Direct-to-consumer advertising”, “consumer advertising and pharmaceutical”, “drug
advertising”, “pharmaceutical advertising”, and “prescription drug advertising.” For my search of
mainstream media I used Lexis-Nexis to find all DTC articles that were written in newspapers from
1985 to 1998. The mainstream and academic articles enabled me to identify 1) the overall form of the
marketing phenomenon, 2) the main actors who struggled over the emergence of DTC ads, and 3) their
The Congressional records I used were those covering the FDA’s moratorium on Direct-to-
Consumer advertising.18 Importantly, the records provided congressional testimonies from the FDA
hearings, which, in turn, helped to a) identify the key agents who struggled for and against the
emergence of DTC advertising, and b) elucidate the concerns and motivations of the respective
For this project I interviewed 17 individuals, between April 1997 and January 1999, including 6
practicing physicians, as well as 11 key informants from a local award-winning ‘healthcare’ ad agency.
The latter included individuals from a wide assortment of positions, including advertising directors,
studio managers, client representatives, traffic personnel, as well as a client representative who
previously worked in the marketing department of a major drug manufacturer. Interviewing these
employees helped me better understand the perspective of those working within the pharmaceutical
industry, as well as illuminate how the industry sought to mollify physician concerns.
18. The agency imposed this moratorium between 1983 and 1985, in order to evaluate how legalizing the ads might impact consumers and the healthcare system.
The fourth component of my research approach was surveying the DTC ads that were published in
the mainstream print media. For this task I identified and tracked every prescription drug ad that
appeared in TIME magazine between January 1989 and December 1996. Aside from tracking which
products got advertised and when, I also coded each ad according to their format: e.g. “educational”
ads, “Brand-awareness” ads, and “claim-making” ads. The significance of those categories is discussed
in section 4.2. TIME magazine was chosen because it is a general interest magazine, and, as such,
represents an ideal site to track how the ads were disseminated to the general public. I picked January
1989 as the start date because that was the first month that claim-making ads were used. As for the end
date, December 1996 was selected because it was the last month before the legalization of TV
consumer advertisements, which ushered in a new and very different phase of the marketing
phenomenon. Conducting this media survey served to link the analysis to the actual use of the ads.
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5th Floor, ‘A’ Wing, Shastri Bhavan, Settlement of prosecutions cases – regarding pending prosecution cases. Ministry of Corporate Affairs has decided following actions to be taken by RDs and ROCs immediately. 1. Lok Adalats should be organized on 9th, 16th, 23rd & 30th June by RDs in the offices of concerned ROCs within your jurisdiction between 10.00 AM to 1.00 P.M by giving an adv
Sesso F | Data di nascita 01/08/1971 | Nazionalità italiana Docente di Patologia Clinica presso il Corso di Laurea del e Professioni Sanitarie in Igiene Dentale, l’Università di Docente presso i corsi di aggiornamento professionale organizzato dal ’ Assiprofar-Federfarma (“Il farmacista e Responsabile tecnico Mineralometria Ossea Computerizzata (MOC) presso studio Scud