Microsoft word - koskiniemi, list of public. 2011.doc


Koskiniemi Marjaleena
Publications
Pietiläinen-Nicklén Jenna, Oskari Virtanen, Pekka Kolehmainen, Maija Lappalainen, Lass Uotila, Oili
Salonen, Markus Färkkilä, Marjaleena Koskiniemi
ADEM and virus infection. J Clin Virol. In Press
Jussi O. Virtanen, Jenna Pietilainen-Nicklen, Lasse Uotila, Markus Farkkila, Antti Vaheri, Marjaleena
Koskiniemi. Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating
diseases presenting as oligoclonal bands in cerebrospinal fluid. J Neuroimmunol. 2011, In press.
Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, Kennedy PG. Viral
meningoencephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol
2010;999-1009.
Pietiläinen J, Virtanen JO, Uotila L, Salonen O, Koskiniemi M, Färkkilä M. HHV-6 infection in multiple
sclerosis. A clinical and laboratory analysis. Eur J Neurol 17;506-9, 2010
Loparev VN, Rubtcova EN, Bostik V, Tzaneva V, Sauerbrei A, Robo A, Sattler-Dorbacher E, Hanovcova
I, Stephanova V, Eremin; V, Koskiniemi M, Vancova OE. Distribution of varicella-zoster virus (VZV)
wild type genotypes in northern and southern Europe: evidence for high conservation of circulating
genotypes. Virology 2009;383:216-25.
Koskiniemi M. Viral encephalitis is a multidimensional infection. Leading article. CML Neurology
2008;24:33-38.
Virtanen JO. Herrgård E. Valmari P. Ahlqvist J. Fogdell-Hahn A. Vaheri A. Koskiniemi M. Confirmed
primary HHV-6 infection in children with suspected encephalitis. Neuropediatrics. 38(6):292-7, 2007
Virtanen JO. Färkkilä M. Multanen J. Uotila L. Jääskeläinen AJ. Vaheri A. Koskiniemi M. Evidence for
human herpesvirus 6 variant A antibodies in multiple sclerosis: diagnostic and therapeutic implications. J
Neurovirol 13(4):347-52, 2007
Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, Kennedy PG. Viral encephalitis: a
review of diagnostic methods and guidelines for management. Eur J Neurol. 2005;12:331-43.
Salonen MJH, Vaheri A, Koskiniemi M. IgM and avidity of IgG antibodies in primary HHV-6 infections.
Scand J Infect Dis 2008; 40(5):420-3.
Koskiniemi M. Viral encephalitis through years. A changing panorama, a review.
Comm Curr Res Educ Topics Trends Appl Microbiol. 2008
Koskiniemi M, Virtanen JO. Human herpesvirus 6 in neurological diseases.
Comm Curr Res Educ Topics Trends Appl Microbiol. 2008
Koskiniemi M, Lappalainen M, Schmid S, Rubtcova E, Loparev V.
Genotypic analysis of varicella-zoster virus and its seroprevalence in Finland. Clin Vacc Immunol CVI.
2007;14(9):1057-61.
Mannonen L, Herrgård E, Valmari P, Rautiainen P, Uotila K, Aine M-R, Karttunen-Lewandowski P,
Sankala J, Wallden T, Koskiniemi M.
Primary HHV-6 infection in CNS can cause a severe disease. Ped Neurol 2007;37(3):186-91.
Salonen MJH, Koskiniemi M. Kinnunen E. Aine MR. Junttila O. Linnavuori K. Vaheri A. Ihmisen
herpesvirus 6. Duodecim 2006;122(13):1607-11.
Jaaskelainen AJ. Piiparinen H. Lappalainen M. Koskiniemi M. Vaheri A.
Multiplex-PCR and oligonucleotide microarray for detection of eight different herpesviruses from clinical specimens. J Clin Virol. 2006;37(2):83-90. Virtanen OJ. Siren V. Multanen J. Farkkila M. Leivo I. Vaheri A. Koskiniemi M. Plasminogen activators and their inhibitors in human saliva and salivary gland tissue. Eur J Oral Sci. 2006;114(1):22-6. Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, Kennedy PG. Viral encephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol. 2005 May;12(5):331-43. Review. Virtanen JO, Zabriskie JB, Siren V, Friedman JE, Lyons MJ, Edgar M, Vaheri A, Koskiniemi M. Co-localization of human herpes virus 6 and tissue plasminogen activator in multiple sclerosis brain tissue. Med Sci Monit. 2005 Mar;11(3):BR84-7. Koskiniemi M, Donner M. [Neurological examination of a child. A book in Finnish]. 2004:1-234. Jaamaa S, Salonen M, Seppala I, Piiparinen H, Sarna S, Koskiniemi M. Varicella zoster and Borrelia burgdorferi are the main agents associated with facial paresis, especially in children. J Clin Virol. 2003 Jul;27(2):146-51. Mustonen K, Mustakangas P, Uotila L, Muir P, Koskiniemi M. Viral infections in neonates with seizures. J Perinat Med. 2003;31(1):75-80. Mustonen K, Uotila L, Laitinen R, Koskiniemi M. CSF findings in neonates with seizures; infectious and noninfectious. J Perinat Med. 2003;31(1):69-74. Koskiniemi M, Piiparinen H, Rantalaiho T, Eranko P, Farkkila M, Raiha K,Salonen EM, Ukkonen P, Vaheri A. Acute central nervous system complications in varicella zoster virus infections. J Clin Virol. 2002 Dec;25(3):293-301. Teesalu T, Kulla A, Asser T, Koskiniemi M, Vaheri A. Tissue plasminogen activator as a key effector in neurobiology and neuropathology. Biochem Soc Trans. 2002 Apr;30(2):183-9. Review. Salonen MJ, Siimes MA, Salonen EM, Vaheri A, Koskiniemi M. Antibody status to HHV-6 in children with leukaemia. Leukemia. 2002 Apr;16(4):716-9. Gencay M, Koskiniemi M, Fellman V, Ammala P, Vaheri A, Puolakkainen M. Chlamydia trachomatis infection in mothers with preterm delivery and in their newborn infants. APMIS. 2001 Sep;109(9):636-40. Koskiniemi M, Rantalaiho T, Piiparinen H, von Bonsdorff CH, Farkkila M, Jarvinen A, Kinnunen E, Koskiniemi S, Mannonen L, Muttilainen M, Linnavuori K, Porras J, Puolakkainen M, Raiha K, Salonen EM, Ukkonen P, Vaheri A, Valtonen V; Study Group. Infections of the central nervous system of suspected viral origin: a collaborative study from Finland. J Neurovirol. 2001 Oct;7(5):400-8. Mustonen K, Mustakangas P, Valanne L, Professor MH, Koskiniemi M. Congenital varicella-zoster virus infection after maternal subclinical infection: clinical and neuropathological findings. J Perinatol. 2001 Mar;21(2):141-6. Review. Rantalaiho T, Farkkila M, Vaheri A, Koskiniemi M. Acute encephalitis from 1967 to 1991. J Neurol Sci. 2001 Mar 1;184(2):169-77. Juntunen A, Herrgard E, Mannonen L, Korppi M, Linnavuori K, Vaheri A, Koskiniemi M. A major role of viruses in convulsive status epilepticus in children: a prospective study of 22 children. Eur J Pediatr. 2001 Jan;160(1):37-42. Gencay M, Koskiniemi M, Ammala P, Fellman V, Narvanen A, Wahlstrom T, Vaheri A, Puolakkainen M. Chlamydia trachomatis seropositivity is associated both with stillbirth and preterm delivery. APMIS. 2000 Sep;108(9):584-8. Rantala H, Mannonen L, Ahtiluoto S, Linnavuori K, Herva R, Vaheri A, Koskiniemi M. Human herpesvirus-6 associated encephalitis with subsequent infantile spasms and cerebellar astrocytoma. Dev Med Child Neurol. 2000 Jun;42(6):418-21. Mustakangas P, Sarna S, Ammala P, Muttilainen M, Koskela P, Koskiniemi M. Human cytomegalovirus seroprevalence in three socioeconomically different urban areas during the first trimester: a population-based cohort study. Int J Epidemiol. 2000 Jun;29(3):587-91. Ahtiluoto S, Mannonen L, Paetau A, Vaheri A, Koskiniemi M, Rautiainen P, Muttilainen M. In situ hybridization detection of human herpesvirus 6 in brain tissue from fatal encephalitis. Pediatrics. 2000 Feb;105(2):431-3. Koskiniemi M. Progressive myoclonus epilepsies. In Handbook of Clinical Nneurology (eds. Vinken PJ, Bruyn GW). The Epilepsies. Part II (ed. H. Meinardi). 2000:73(29);293-306. Nybo T, Koskiniemi M. Cognitive indicators of vocational outcome after severe traumatic brain injury (TBI) in childhood. Brain Inj. 1999 Oct;13(10):759-66. Friedman JE, Lyons MJ, Cu G, Ablashl DV, Whitman JE, Edgar M, Koskiniemi M, Vaheri A, Zabriskie JB. The association of the human herpesvirus-6 and MS. Mult Scler. 1999 Oct;5(5):355-62. Lappalainen M, Soderlund M, Piiparinen H, Puolakkainen M, Mannonen L, Suni J, von Bonsdorff CH, Koskiniemi M, Hyypia T, Vaheri A, Hedman K. [Gene amplification methods in viral diagnostics]. Duodecim. 1999;115(9):1031-6. Review. Finnish. No abstract available. Lehesjoki AE, Koskiniemi M. Progressive myoclonus epilepsy of Unverricht-Lundborg type. Epilepsia. 1999;40 Suppl 3:23-8. Review. Akenami FO, Siren V, Wessman M, Koskiniemi M, Vaheri A. Tissue plasminogen activator gene expression in multiple sclerosis brain tissue. J Neurol Sci. 1999 May 1;165(1):71-6. Lehesjoki AE, Koskiniemi M. Clinical features and genetics of progressive myoclonus epilepsy of the Univerricht-Lundborg type. Ann Med. 1998 Oct;30(5):474-80. Review. Mustonen K, Mustakangas P, Smeds M, Mannonen L, Uotila L, Vaheri A, Koskiniemi M. Antibodies to varicella zoster virus in the cerebrospinal fluid of neonates with seizures. Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F57-61. Koskiniemi M, Van Vleymen B, Hakamies L, Lamusuo S, Taalas J. Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study comparing the efficacy and safety of three dosages of oral piracetam with placebo. J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):344-8. Gencay M, Puolakkainen M, Wahlstrom T, Ammala P, Mannonen L, Vaheri A, Koskiniemi ML. Chlamydia trachomatis detected in human placenta. J Clin Pathol. 1997 Oct;50(10):852-5. Farkkila M, Tiainen T, Koskiniemi M. Epidemiology and prognosis of acute myelitis in Southern Finland. J Neurol Sci. 1997 Nov 25;152(2):140-6. Koskiniemi M, Korppi M, Mustonen K, Rantala H, Muttilainen M, Herrgard E, Ukkonen P, Vaheri A. Epidemiology of encephalitis in children. A prospective multicentre study. Eur J Pediatr. 1997 Jul;156(7):541-5. Akenami FO, Koskiniemi M, Ekanem EE, Bolarin DM, Vaheri A. Seroprevalence and coprevalence of HIV and HBsAg in Nigerian children with/without protein energy malnutrition. Acta Trop. 1997 Apr 15;64(3-4):167-74. Virtaneva K, D'Amato E, Miao J, Koskiniemi M, Norio R, Avanzini G, Franceschetti S, Michelucci R, Tassinari CA, Omer S, Pennacchio LA, Myers RM, Dieguez-Lucena JL, Krahe R, de la Chapelle A, Lehesjoki AE. Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1. Nat Genet. 1997 Apr;15(4):393-6. Akenami FO, Koskiniemi M, Farkkila M, Vaheri A. Cerebrospinal fluid plasminogen activator inhibitor-1 in patients with neurological disease. J Clin Pathol. 1997 Feb;50(2):157-60. Akenami FO, Koskiniemi M, Siimes MA, Ekanem EE, Bolarin DM, Vaheri A. Assessment of plasma fibronectin in malnourished Nigerian children. J Pediatr Gastroenterol Nutr. 1997 Feb;24(2):183-8. Virkola K, Lappalainen M, Valanne L, Koskiniemi M. Radiological signs in newborns exposed to primary Toxoplasma infection in utero. Pediatr Radiol. 1997 Feb;27(2):133-8. Koskiniemi M, Mannonen L, Kallio A, Vaheri A. Luminometric microplate hybridization for detection of varicella-zoster virus PCR product from cerebrospinal fluid. J Virol Methods. 1997 Jan;63(1-2):71-9. Koskiniemi M, Ammala P, Narvanen A, Saikku P, Soderlund M, Koskela P, Laurila P, Vaheri A. Stillbirths and maternal antibodies to Chlamydia trachomatis. A new EIA test for serology. Acta Obstet Gynecol Scand. 1996 Aug;75(7):657-61. Akenami FO, Siren V, Koskiniemi M, Siimes MA, Teravainen H, Vaheri A. Cerebrospinal fluid activity of tissue plasminogen activator in patients with neurological diseases. J Clin Pathol. 1996 Jul;49(7):577-80. Pennacchio LA, Lehesjoki AE, Stone NE, Willour VL, Virtaneva K, Miao J, D'Amato E, Ramirez L, Faham M, Koskiniemi M, Warrington JA, Norio R, de la Chapelle A, Cox DR, Myers RM. Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1) Science. 1996 Mar 22;271(5256):1731-4. Koskiniemi M, Piiparinen H, Mannonen L, Rantalaiho T, Vaheri A. Herpes encephalitis is a disease of middle aged and elderly people: polymerase chain reaction for detection of herpes simplex virus in the CSF of 516 patients with encephalitis. The Study Group. J Neurol Neurosurg Psychiatry. 1996 Feb;60(2):174-8. Koskiniemi M, Gencay M, Salonen O, Puolakkainen M, Farkkila M, Saikku P, Vaheri A. Chlamydia pneumoniae associated with central nervous system infections. Eur Neurol. 1996;36(3):160-3. Koskiniemi M, Saarinen A, Klapper PE, Sarna S, Cleator G, Vaheri A. Familial herpes encephalitis. Lancet. 1995 Dec 9;346(8989):1553. No abstract available. Gencay M, Koskiniemi M, Saikku P, Puolakkainen M, Raivio K, Koskela P, Vaheri A. Chlamydia trachomatis seropositivity during pregnancy is associated with perinatal complications. Clin Infect Dis. 1995 Aug;21(2):424-6. Koskiniemi M, Piiparinen H, Leikola M, Farkkila M, Vaheri A. Poor antibody production in fatal herpes encephalitis. Study Group. J Infect Dis. 1995 Jun;171(6):1692-3. No abstract available. Lappalainen M, Koskiniemi M, Hiilesmaa V, Ammala P, Teramo K, Koskela P, Lebech M, Raivio KO, Hedman K. Outcome of children after maternal primary Toxoplasma infection during pregnancy with emphasis on avidity of specific IgG. The Study Group. Pediatr Infect Dis J. 1995 May;14(5):354-61. Koskiniemi M, Kyykka T, Nybo T, Jarho L. Long-term outcome after severe brain injury in preschoolers is worse than expected. Arch Pediatr Adolesc Med. 1995 Mar;149(3):249-54. Kaasinen S, Pyykko I, Koskiniemi ML, Vaheri A. Culturing of acoustic neuroma--methodological aspects. Acta Otolaryngol Suppl. 1995;520 Pt 1:25-6. Piiparinen H, Koskiniemi M, Vaheri A. [Polymerase chain reaction assay of HSV in the rapid diagnosis of encephalitis] Duodecim. 1995;111(2):129-33. Finnish. No abstract available. Lappalainen M, Sintonen H, Koskiniemi M, Hedman K, Hiilesmaa V, Ammala P, Teramo K, Koskela P. Cost-benefit analysis of screening for toxoplasmosis during pregnancy. Scand J Infect Dis. 1995;27(3):265-72. Lappalainen M, Koskela P, Hedman K, Teramo K, Ammala P, Hiilesmaa V, Raivio KO, Koskiniemi M. Screening of toxoplasmosis during pregnancy. Isr J Med Sci. 1994 May-Jun;30(5-6):362-3. No abstract available. Koskiniemi M. CNS manifestations associated with Mycoplasma pneumoniae infections: summary of cases at the University of Helsinki and review. Clin Infect Dis. 1993 Aug;17 Suppl 1:S52-7. Review. Lehesjoki AE, Koskiniemi M, Norio R, Tirrito S, Sistonen P, Lander E, de la Chapelle A. Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: linkage disequilibrium allows high resolution mapping. Hum Mol Genet. 1993 Aug;2(8):1229-34. Farkkila M, Koskiniemi M, Vaheri A. Clinical spectrum of neurological herpes simplex infection. Acta Neurol Scand. 1993 Apr;87(4):325-8. Lappalainen M, Koskela P, Koskiniemi M, Ammala P, Hiilesmaa V, Teramo K, Raivio KO, Remington JS, Hedman K. Toxoplasmosis acquired during pregnancy: improved serodiagnosis based on avidity of IgG. J Infect Dis. 1993 Mar;167(3):691-7. Koskiniemi M. [Diagnosis and treatment of congenital toxoplasmosis] Duodecim. 1993;109(14):1260-4. Review. Finnish. No abstract available. Lehesjoki AE, Koskiniemi M, Pandolfo M, Antonelli A, Kyllerman M, Wahlstrom J, Nergardh A, Burmeister M, Sistonen P, Norio R, et al. Linkage studies in progressive myoclonus epilepsy: Unverricht-Lundborg and Lafora's diseases. Neurology. 1992 Aug;42(8):1545-50. Lappalainen M, Koskela P, Hedman K, Teramo K, Ammala P, Hiilesmaa V, Koskiniemi M. Incidence of primary toxoplasma infections during pregnancy in south. Finland: a prosp. cohort study. Scand J Infect Dis. 1992;24(1):97-104. Rajantie J, Siimes MA, Taskinen E, Lappalainen M, Koskiniemi M. White blood cells in infants with congenital toxoplasmosis: transient appearance of cALL antigen on reactive marrow lymphocytes. Scand J Infect Dis. 1992;24(2):227-32. Lehesjoki AE, Koskiniemi M, Sistonen P, Norio R, de la Chapelle A. [Localization of progressive myoclonus epilepsy gene opens new horizons for epilepsy research] Duodecim. 1992;108(4):355-7. Review. Finnish. No abstract available. Koskiniemi M, Lappalainen M, Koskela P, Hedman K, Ammala P, Hiilesmaa V, Teramo K. The program for antenatal screening of toxoplasmosis in Finland: a prospective cohort study. Scand J Infect Dis Suppl. 1992;84:70-4. Rautonen J, Koskiniemi M, Vaheri A. Prognostic factors in childhood acute encephalitis. Pediatr Infect Dis J. 1991 Jun;10(6):441-6. Koskiniemi M, Rautonen J, Lehtokoski-Lehtiniemi E, Vaheri A. Epidemiology of encephalitis in children: a 20-year survey. Ann Neurol. 1991 May;29(5):492-7. Lehesjoki AE, Koskiniemi M, Sistonen P, Miao J, Hastbacka J, Norio R, de la Chapelle A. Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3696-9. Koskiniemi M, Rajantie J, Rautonen J, Laipio ML, Salonen EM, Siimes MA, Vaheri A. Fibronectin concentration in cerebrospinal fluid reflects early central nervous system involvement in children with acute lymphoblastic leukemia. Leuk Res. 1990;14(5):449-52. Koskiniemi M, Vaheri A, Farkkila M. [Neurovirological diagnostics] Duodecim. 1990;106(21):1482-7. Review. Finnish. No abstract available. Lehtokoski-Lehtiniemi E, Koskiniemi ML. Mycoplasma pneumoniae encephalitis: a severe entity in children. Pediatr Infect Dis J. 1989 Sep;8(9):651-3. No abstract available. Rajantie J, Koskiniemi M, Siimes M, Salonen EM, Vaheri A. CSF fibronectin in Burkitt's lymphoma: an early marker for CNS involvement. Eur J Haematol. 1989 Mar;42(3):313-4. No abstract available. Blokziji ML, Koskiniemi M. Echovirus 6 encephalitis in a preterm baby. Lancet. 1989 Jul 15;2(8655):164-5. No abstract available. Koskiniemi M, Lappalainen M, Hedman K. Toxoplasmosis needs evaluation. An overview and proposals. Am J Dis Child. 1989 Jun;143(6):724-8. Review. No abstract available. Rautonen J, Koskiniemi M, Siimes MA, Salonen EM, Vaheri A. Elevated cerebrospinal fluid fibronectin concentration at diagnosis indicates poor prognosis in children with acute lymphoblastic leukemia. Int J Cancer. 1989 Jan 15;43(1):32-5. Koskiniemi M, Vaheri A. Effect of measles, mumps, rubella vaccination on pattern of encephalitis in children. Lancet. 1989 Jan 7;1(8628):31-4. Koskiniemi M, Paetau R, Linnavuori K. Severe encephalitis associated with disseminated echovirus 22 infection. Scand J Infect Dis. 1989;21(4):463-6. Koskiniemi M, Happonen JM, Jarvenpaa AL, Pettay O, Vaheri A. Neonatal herpes simplex virus infection: a report of 43 patients. Pediatr Infect Dis J. 1989 Jan;8(1):30-5. Koskiniemi M. Malignancy markers in the cerebrospinal fluid. Eur J Pediatr. 1988 Oct;148(1):3-8. Review. Lappalainen M, Koskiniemi M. [Congenital toxoplasmosis] Duodecim. 1988;104(4):239-46. Finnish. No abstract available. Koskiniemi M, Donner M. [Neurological examination of a child. A book in Finnish]. 1987:1-156. Koskiniemi M, Wilska M, Icen A, Julkunen I, Leisti J, Vaheri A. Mental retardation associated with elevated cerebrospinal fluid antibody levels to herpes simplex, adeno and mumps viruses. Neuropediatrics. 1987 May;18(2):110-1. No abstract available. Ahokas A, Rimon R, Koskiniemi M, Vaheri A, Julkunen I, Sarna S. Viral antibodies and interferon in acute psychiatric disorders. J Clin Psychiatry. 1987 May;48(5):194-6. Koskiniemi M. Baltic myoclonus. Ann Clin Res. 1987;19(5):311-2. No abstract available. Peltola H, Turpeinen M, Koskiniemi M. An infant with simultaneous beta-lactamase-positive Haemophilus influenzae meningitis and beta-lactamase-negative H. influenzae septicemia, Escherichia coli pyelonephritis and herpes encephalitis. Acta Paediatr Scand. 1986 May;75(3):499-501. Julkunen I, Koskiniemi ML, Lehtokoski-Lehtiniemi E, Sainio K, Vaheri A. [Chronic encephalitis caused by mumps virus] Duodecim. 1986;102(8):463-9. Finnish. No abstract available. Koskiniemi M. [Diagnosis and treatment of encephalitis] Duodecim. 1986;102(11):739-47. Finnish. No abstract available. Koskiniemi ML. Baltic myoclonus. Adv Neurol. 1986;43:57-64. Julkunen I, Koskiniemi M, Lehtokoski-Lehtiniemi E, Sainio K, Vaheri A. Chronic mumps virus encephalitis. Mumps antibody levels in cerebrospinal fluid. J Neuroimmunol. 1985 May;8(2-3):167-75. Koskiniemi M, Laakso J, Kuurne T, Laipio M, Harkonen M. Indole levels in human lumbar and ventricular cerebrospinal fluid and the effect of L-tryptophan administration. Acta Neurol Scand. 1985 Feb;71(2):127-32. Ahokas A, Koskiniemi ML, Vaheri A, Rimon R. Altered white cell count, protein concentration and oligoclonal IgG bands in the cerebrospinal fluid of many patients with acute psychiatric disorders. Neuropsychobiology. 1985;14(1):1-4. Julkunen I, Lehtokoski-Lehtiniemi E, Koskiniemi M, Vaheri A. Elevated mumps antibody titers in the cerebrospinal fluid suggesting chronic mumps virus infection in the central nervous system. Pediatr Infect Dis. 1985 Jan-Feb;4(1):99. No abstract available. Koskiniemi M, Vaheri A, Taskinen E. Cerebrospinal fluid alterations in herpes simplex virus encephalitis. Rev Infect Dis. 1984 Sep-Oct;6(5):608-18. Review. Taskinen E, Koskiniemi ML, Vaheri A. Herpes simplex virus encephalitis. Prolonged intrathecal IgG synthesis and cellular activity in the cerebrospinal fluid with transient impairment of blood-brain barrier. J Neurol Sci. 1984 Mar;63(3):331-8. Ketonen L, Koskiniemi ML. Gyriform calcification after herpes simplex virus encephalitis. J Comput Assist Tomogr. 1983 Dec;7(6):1070-2. Laakso JT, Koskiniemi ML, Wahlroos O, Harkonen M. Simultaneous determination of tryptophan and its 5-hydroxy metabolites in human cerebrospinal fluid by reversed phase liquid chromatography with electrochemical detection. Scand J Clin Lab Invest. 1983 Oct;43(6):463-72. Koskiniemi M, Donner M, Pettay O. Clinical appearance and outcome in mumps encephalitis in children. Acta Paediatr Scand. 1983 Jul;72(4):603-9. Vaheri A, Keski-Oja J, Salonen EM, Koskiniemi ML. Cerebrospinal fluid IgG bands and virus-specific IgG, IgM, and IgA antibodies in herpes simplex virus encephalitis. J Neuroimmunol. 1982 Dec;3(4):247-61. Vaheri A, Julkunen I, Koskiniemi ML. Chronic encephalomyelitis with specific increase in intrathecal mumps antibodies. Lancet. 1982 Sep 25;2(8300):685-8. Koskiniemi ML, Vaheri A. Diagnostic value of cerebrospinal fluid antibodies in herpes simplex virus encephalitis. J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):239-42. Koskiniemi ML, Vaheri A, Valtonen S. [Early diagnosis of acute herpesvirus encephalitis] Duodecim. 1982;98(1):10-7. Review. Finnish. No abstract available. Koskiniemi ML, Vaheri A. Acute encephalitis of viral origin. Scand J Infect Dis. 1982;14(3):181-7. Koskiniemi ML, Vaheri A, Valtonen S, Haltia M, Kaste M, Manninen V, Salonen EM, Icen A, Cantell K. Trial with human leucocyte interferon and vidarabine in herpes simplex virus encephalitis: diagnostic and therapeutic problems. Acta Med Scand Suppl. 1982;668:150-60. Koskiniemi ML, Vaheri A, Manninen V, Nikki P. Ascending myelitis with high antibody titer to herpes simplex virus in the cerebrospinal fluid. J Neurol. 1982;227(3):187-91. No abstract available. Koskiniemi M, Manninen V, Vaheri A, Sainio K, Eistola P, Karli P. Acute encephalitis. A survey of epidemiological, clinical and microbiological features covering a twelve-year period. Acta Med Scand. 1981;209(1-2):115-20. Koskiniemi M, Ketonen L. Herpes simplex virus encephalitis: progression of lesion shown by CT. J Neurol. 1981;225(1):9-13. Koskiniemi M, Vaheri A, Manninen V, Valtonen S, Ketonen L, Taskinen E, Sainio K, Karli P, Haltia M. Herpes simplex virus encephalitis: new diagnostic and clinical features and results of therapy. Arch Neurol. 1980 Dec;37(12):763-7. Koskiniemi M, Hyyppa M, Sainio K, Salmi T, Sarna S, Uotila L. Transient effect of L-tryptophan in progressive myoclonus epilepsy without Lafora bodies: clinical and electrophysiological study. Epilepsia. 1980 Aug;21(4):351-7. Koskiniemi ML. Deficient intestinal absorption of L-tryptophan in progressive myoclonus epilepsy without Lafora bodies. J Neurol Sci. 1980 Jul;47(1):1-6. Ketonen L, Koskiniemi ML. Computed tomography appearance of Herpes Simplex encephalitis. Clin Radiol. 1980 Mar;31(2):161-5. Koskiniemi M, Hakamies L. Valporic acid and coma. Neurology. 1979 Oct;29(10):1430. No abstract available. Norio R, Koskiniemi M. Progressive myoclonus epilepsy: genetic and nosological aspects with special reference to 107 Finnish patients. Clin Genet. 1979 May;15(5):382-98. Koskiniemi M, Palo J. Urinary excretion of indican in progressive myoclonus epilepsy without Lafora bodies. The effect of sodium valproate. J Neurol Sci. 1978 Dec;39(2-3):235-9. Raivio M, Koskiniemi M. Hearing disorders after Haemophilus influenzae meningitis. Comparison of different drug regimens. Arch Otolaryngol. 1978 Jun;104(6):340-4. Koskiniemi M, Pettay O, Raivio M, Sarna S. Haemophilus influenzae meningitis. A comparison between chloramphenicol and ampicillin therapy with special reference to impaired hearing. Acta Paediatr Scand. 1978 Jan;67(1):17-24. Koskiniemi M. Findings in routine laboratory examination in progressive myoclonus epilepsy. Acta Neurol Scand. 1975 Jan;51(1):12-20. Koskiniemi M. Psychological findings in progressive myoclonus epilepsy without Lafora bodies. Epilepsia. 1974 Dec;15(4):537-45. No abstract available. Koskiniemi M, Toivakka E, Donner M. Progressive myoclonus epilepsy. Electroencephalographical findings. Acta Neurol Scand. 1974;50(3):333-59. No abstract available. Koskiniemi M, Donner M, Majuri H, Haltia M, Norio R. Progressive myoclonus epilepsy. A clinical and histopathological study. Acta Neurol Scand. 1974;50(3):307-32. No abstract available. Koskiniemi M, Donner M. [Progressive myoclonus epilepsy] Duodecim. 1972;88(1):30-4. Finnish. No abstract available.

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the near future. To be accepted, however, the nitraterespiratory rate and a greater increase in oxygen saturationformulation may need further refinement. with isosorbide dinitrate than with furosemide. The fall inheart rate is of interest, because it suggests reducedDepartment of Cardiovascular Medicine, University of Birmingham andsympathetic drive; in other studies heart rate did notUnive

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Drugs and breastfeeding: There are actually few medications that are contraindicated during breastfeeding, including bromocriptine, cyclophosphamide, cyclosporine, doxorubicin, ergotamine, lithium, methotrexate and phenindione. Many other medications may require temporarily stopping breastfeeding, are compatible with breastfeeding, can be used with caution, or the effect on the baby is unkn

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