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Microsoft word - k.zlem.nyek_petheogl_2011.doc

Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM Eredeti közlemények (cikkek):

1: Petheő GL, Orient A, Baráth M, Kovács I, Réthi B, Lányi A, Rajki A, Rajnavölgyi
E, Geiszt M. Molecular and functional characterization of Hv1 proton channel in human
granulocytes. PLoS One. 2010 Nov 23;5(11):e14081. IF: 4.351 (2010-ben), Cit:0
2: Petheo GL, Girardin NC, Goossens N, Molnar GZ, Demaurex N. Role of nucleotides
and phosphoinositides in the stability of electron and proton currents associated with the
phagocytic NADPH oxidase. Biochem J. 2006 Dec 15;400(3):431-8. IF:4.100, Cit:6
3: Demaurex N, Petheo GL. Electron and proton transport by NADPH oxidases. Philos
Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2315-25. If:4.128 (2004-ben),
Cit:19 (Review)
4: Petheo GL, Demaurex N. Voltage- and NADPH-dependence of electron currents
generated by the phagocytic NADPH oxidase.Biochem J. 2005 Jun 1;388(Pt 2):485-91.
If:4.278 (2004-ben), Cit:9
5: Petheo GL, Maturana A, Spat A, Demaurex N. Interactions between electron and
proton currents in excised patches from human eosinophils. J Gen Physiol. 2003
Dec;122(6):713-26. If:5.120, Cit:10
6: Makara JK, Koncz P, Petheo GL, Spat A. Role of cell volume in K+-induced Ca2+
signaling by rat adrenal glomerulosa cells. Endocrinology. 2003 Nov;144(11):4916-22.
If:5.063, Cit:1
7: Molnar Z, Petheo GL, Fulop C, Spat A. Effects of osmotic changes on the
chemoreceptor cell of rat carotid body. J Physiol. 2003 Jan 15;546(Pt 2):471-81. If:4.352,
Cit:5
8: Petheo GL, Molnar Z, Roka A, Makara JK, Spat A. A pH-sensitive chloride current
in the chemoreceptor cell of rat carotid body. J Physiol. 2001 Aug 15;535(Pt 1):95-106.
If:4.476, Cit:8
9: Czirjak G, Petheo GL, Spat A, Enyedi P. Inhibition of TASK-1 potassium channel by
phospholipase C. Am J Physiol Cell Physiol. 2001 Aug;281(2):C700-8. If:3.896, Cit:52
10: Makara JK, Petheo GL, Toth A, Spat A. pH-sensitive inwardly rectifying chloride
current in cultured rat cortical astrocytes. Glia. 2001 Apr 1;34(1):52-8. If:4.193, Cit:6
11: Makara JK, Petheo GL, Toth A, Spat A. Effect of osmolarity on aldosterone
production by rat adrenal glomerulosa cells. Endocrinology. 2000 May;141(5):1705-10.
If:4.79, Cit:6
12: Deak F, Lasztoczi B, Pacher P, Petheo GL, Valeria Kecskemeti, Spat A. Inhibition
of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells.
Neuropharmacology. 2000 Apr 3;39(6):1029-36. If:4.125, Cit:40
Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM
13: Varnai P, Petheo GL, Makara JK, Spat A. Electrophysiological study on the high
K+ sensitivity of rat glomerulosa cells. Pflugers Arch. 1998 Feb;435(3):429-31. If:2.529,
Cit:8
A fenti közlemények kumulatív impakt faktora: 56.216 összes/független idézettsége:
217/165, H-index: 8
Konferencia kiadványban megjelent idézhető absztraktok:
Petheo GL
, Demaurex N
Voltage-dependence of the phagocyte NADPH-oxidase measured in excised patches
BIOPHYSICAL JOURNAL 86 (1): 555A-555A Part 2 Suppl. S JAN 2004
Petheo GL
, Molnar Z, Roka A, et al.
Characterization of a pH-sensitive anion current in the chemoreceptor cell of rat carotid
body JOURNAL OF PHYSIOLOGY-LONDON 526: 5P-5P Suppl. S AUG 2000
Petheo GL, Varnai P, Spat A
Electrophysiological differences between rat adrenal glomerulosa and fasciculata cells
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 356 (4): 106-106
Suppl. 1 1997
Spat A, Varnai P, Deak F, Petheo G
Potassium activates an inward rectifying calcium current (I-gl) NAUNYN-
SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 356 (4): 100-100 Suppl. 1
1997

Közleményeimet idéző független munkák (közlemények számmal jelezve a fentebbi
listának megfelelően). A válogatott közlemények sorszáma vastaggal szedve:

1: 0
2: 1. Musset B, Cherny VV, Morgan D and DeCoursey TE (2009) The intimate and mysterious
relationship between proton channels and NADPH oxidase. Febs Letters 583:7-12 2. DeCoursey TE (2008) Voltage-gated proton channels: what's next ? Journal of Physiology- 3. DeCoursey TE (2008) Voltage-gated proton channels. Cellular and Molecular Life Sciences 4. Ahluwalia J (2008) Characterisation of electron currents generated by the human neutrophil NADPH oxidase. Biochemical and Biophysical Research Communications 368:656-661 5. DeCoursey TE and Cherny VV (2007) Pharmacology of voltage-gated proton channels. Current Pharmaceutical Design 13:2406-2420 Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM 6. Morgan D, Cherny VV, Finnegan A, Bollinger J, Gelb MH and DeCoursey TE (2007) Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA(2)alpha activity. Journal of Physiology-London 579:327-344
3: 1. Murphy R and DeCoursey TE (2006) Charge compensation during the phagocyte
respiratory burst. Biochimica et Biophysica Acta-Bioenergetics 1757:996-1011 2. Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirjak G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM et al (2006) The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. Journal of General Physiology 127:659-672 3. DeCoursey TE (2010) Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes. Physiology 25:27-40 4. Li Q, Spencer NY, Oakley FD, Buettner GR and Engelhardt JF (2009) Endosomal Nox2 Facilitates Redox-Dependent Induction of NF-kappa B by TNF-alpha. Antioxidants & Redox Signaling 11:1249-1263 5. Oakley FD, Abbott D, Li Q and Engelhardt JF (2009) Signaling Components of Redox Active Endosomes: The Redoxosomes. Antioxidants & Redox Signaling 11:1313-1333 6. Lamb FS, Moreland JG and Miller FJ (2009) Electrophysiology of Reactive Oxygen Production in Signaling Endosomes. Antioxidants & Redox Signaling 11:1335-1347 7. Fisher AB (2009) Redox Signaling Across Cell Membranes. Antioxidants & Redox 8. Giambelluca MS and Gende OA (2009) Effect of glycine on the release of reactive oxygen species in human neutrophils. International Immunopharmacology 9:32-37 9. Brechard S and Tschirhart EJ (2008) Regulation of superoxide production in neutrophils: role of calcium influx. Journal of Leukocyte Biology 84:1223-1237 10. De Simoni A, Allen NJ and Attwell D (2008) Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current. European Journal of Neuroscience 28: 1146-1156 11. Nauseef WM (2008) Nox enzymes in immune cells. Seminars in Immunopathology 30:195- 12. Matteucci E and Giampietro O (2008) Flow cytometry study of leukocyte function: Analytical comparison of methods and their applicability to clinical research. Current Medicinal Chemistry 15:596-603 13. Bogeski I, Mirceski V and Hoth M (2008) Probing the redox activity of T-lymphocytes deposited at electrode surfaces with voltammetric methods. Clinical Chemistry and Laboratory Medicine 46:197-203 14. Cheng YM, Kelly T and Church J (2008) Potential contribution of a voltage-activated proton conductance to acid extrusion from rat hippocampal neurons. Neuroscience 151:1084-1098 15. Morihata H, Kawawaki J, Okina M, Sakai H, Notomi T, Sawada M and Kuno M (2008) Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms. Pflugers Archiv-European Journal of Physiology 455:829-838 16. Lassegue B (2007) How does the chloride/proton antiporter ClC-3 control NADPH oxidase? 17. DeCoursey TE (2008) Voltage-gated proton channels: what's next ? Journal of Physiology- Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM 18. DeCoursey TE (2008) Voltage-gated proton channels. Cellular and Molecular Life Sciences 19. DeCoursey TE and Cherny VV (2007) Pharmacology of voltage-gated proton channels. Current Pharmaceutical Design 13: 2406-2420
4:
1. Musset B, Smith SME, Rajan S, Cherny VV, Sujai S, Morgan D and DeCoursey TE (2010)
Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating. Journal of Physiology-London 588:1435-1449 2. Musset B, Capasso M, Cherny VV, Morgan D, Bhamrah M, Dyer MJS and DeCoursey TE (2010) Identification of Thr(29) as a Critical Phosphorylation Site That Activates the Human Proton Channel Hvcn1 in Leukocytes. Journal of Biological Chemistry 285:5117-5121 3. Ramsey IS, Ruchti E, Kaczmarek JS and Clapham DE (2009) Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proceedings of the National Academy of Sciences of the United States of America 106:7642-7647 4. Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Gudermann T, Schulz R, Seeger W, Grimminger F and Weissmann N (2008) Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. European Respiratory Journal 32:1639-1651 5. Rada B, Hably C, Meczner A, Timar C, Lakatos G, Enyedi P and Ligeti E (2008) Role of Nox2 in elimination of microorganisms. Seminars in Immunopathology 30:237-253 6. DeCoursey TE and Ligeti E (2005) Regulation and termination of NADPH oxidase activity. Cellular and Molecular Life Sciences 62 :2173-2193 7. DeCoursey TE (2008) Voltage-gated proton channels. Cellular and Molecular Life Sciences 8. DeCoursey TE and Cherny VV (2007) Pharmacology of voltage-gated proton channels. Current Pharmaceutical Design 13:2406-2420 9. Murphy R and DeCoursey TE (2006) Charge compensation during the phagocyte respiratory burst. Biochimica et Biophysica Acta-Bioenergetics 1757:996-1011
5:
1. Nemeth T, Futosi K, Hably C, Brouns MR, Jakob SM, Kovacs M, Kertesz Z, Walzog B,
Settleman J and Mocsai A (2010) Neutrophil Functions and Autoimmune Arthritis in the Absence of p190RhoGAP: Generation and Analysis of a Novel Null Mutation in Mice. Journal of Immunology 185:3064-3075 2. DeCoursey TE (2010) Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes. Physiology 25:27-40 3. DeCoursey TE (2008) Voltage-gated proton channels: what's next ? Journal of Physiology- 4. DeCoursey TE (2008) Voltage-gated proton channels. Cellular and Molecular Life Sciences 5. DeCoursey TE and Cherny VV (2007) Pharmacology of voltage-gated proton channels. Current Pharmaceutical Design 13:2406-2420 6. Morgan D, Cherny VV, Finnegan A, Bollinger J, Gelb MH and DeCoursey TE (2007) Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA(2)alpha activity. Journal of Physiology-London 579:327-344 7. Rada BK, Geiszt M, Hably C and Ligeti E (2005) Consequences of the electrogenic function of the phagocytic NADPH oxidase. Philosophical Transactions of the Royal Society B-Biological Sciences 360:2293-2300 Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM 8. Morgan D, Cherny VV, Murphy R, Katz BZ and DeCoursey TE (2005) The pH dependence of NADPH oxidase in human eosinophils. Journal of Physiology-London 569:419-431 9. DeCoursey TE and Ligeti E (2005) Regulation and termination of NADPH oxidase activity. Cellular and Molecular Life Sciences 62 :2173-2193 10. Bankers-Fulbright JL, Kephart GM, Bartemes KR, Kita H and O'Grady SM (2004) Platelet- activating factor stimulates cytoplasmic alkalinization and granule acidification in human eosinophils. Journal of Cell Science 117:5749-5757 1. Yamamoto S, Shioya T, Ehara T, Iwamoto T. Method and apparatus for studying cell volume regulation. Folia Pharmacol Jap. 2010;135(6):245-9. 1. Muñoz-Cabello AM, Villadiego J, Toledo-Aral JJ, López-Barneo J, Echevarría M. AQP1 mediates water transport in the carotid body. Pflugers Archiv European Journal of Physiology. 2010;459(5):775-83. 2. Abudara V, Eyzaguirre C. Mechanical sensitivity of carotid body glomus cells. Respiratory Physiology and Neurobiology. 2008;161(2):210-3. 3. Kumar P, Bin-Jaliah I. Adequate stimuli of the carotid body: More than an oxygen sensor? Respiratory Physiology and Neurobiology. 2007;157(1):12-21. 4. Ward DS, Voter WA, Karan S. The effects of hypo- and hyperglycaemia on the hypoxic ventilatory response in humans. J Physiol (Lond ). 2007;582(2):859-69. 5. Jiang RG, Eyzaguirre C. Calcium channels of cultured rat glomus cells in normoxia and acute hypoxia. Brain Res. 2005;1031(1):56-66. 1. Abboud FM. In search of autonomic balance: The good, the bad, and the ugly. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2010;298(6):R1449-67. 2. Tan Z-, Lu Y, Whiteis CA, Simms AE, Paton JFR, Chapleau MW, et al. Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res. 2010;106(3):536-45. 3. Holzer P. Acid-sensitive ion channels and receptors [Internet]; 2009 [cited 2011 Feb 24]. 4. Tan Z-, Lu Y, Whiteis CA, Benson CJ, Chapleau MW, Abboud FM. Acid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells. Circ Res. 2007;101(10):1009-19. 5. López-López JR, Pérez-García MT. An ASIC channel for acid chemotransduction. Circ 6. Pilarski JQ, Hempleman SC. Imidazole binding reagent diethyl pyrocarbonate (DEPC) inhibits avian intrapulmonary chemoreceptor discharge in vivo. Respiratory Physiology and Neurobiology. 2006;150(2-3):144-54. 7. Putnam RW, Filosa JA, Ritucci NA. Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons. American Journal of Physiology - Cell Physiology. 2004;287(6 56-6):C1493-526. 8. Wray S, Smith RD. Mechanisms of action of pH-induced effects on vascular smooth muscle. Mol Cell Biochem. 2004;263(1):163-72. Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM 9. Kim HS, Kam KY, Ryu PD, Hong SJ, Jeon JS, Jeon BH, et al. A gadolinium and pH- sensitive hyperpolarization-activated cation current in acutely isolated single neurones from fasciola hepatica. Parasitology. 2002;125(5):423-30.
9:1. Niemeyer MI, Stutzin A and Sep+¦lveda FV (2002) A voltage-independent K+ conductance
activated by cell swelling in Ehrlich cells is modulated by a G-protein-mediated process. Biochimica et Biophysica Acta - Biomembranes 1562:1-5 2. Talley EM and Bayliss DA (2002) Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels. Volatile anesthetics and neurotransmitters share a molecular site of action. Journal of Biological Chemistry 277:17733-17742 3. Sirois JE, Lynch III C and Bayliss DA (2002) Convergent and reciprocal modulation of a leak K+ current and I<sub>h</sub> by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones. Journal of Physiology 541:717-729 4. Han J, Truell J, Gnatenco C and Kim D (2002) Characterization of four types of background potassium channels in rat cerebellar granule neurons. Journal of Physiology 542:431-444 5. Girard C, Tinel N, Terrenoire C, Romey G, Lazdunski M and Borsotto M (2002) p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. EMBO Journal 21:4439-4448 6. O'Connell AD, Morton MJ and Hunter M (2002) Two-pore domain K+ channels - Molecular sensors. Biochimica et Biophysica Acta - Biomembranes 1566:152-161 7. Han J, Gnatenco C, Sladek CD and Kim D (2003) Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus. Journal of Physiology 546:625-639 8. Elliott JI and Higgins CF (2003) IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis. EMBO Reports 4:189-194 9. Talley EM, Sirois JE, Lei Q and Bayliss DA (2003) Two-pore-domain (KCNK) potassium channels: Dynamic roles in neuronal function. Neuroscientist 9:46-56 10. Lauritzen I, Zanzouri M, Honor+¬ E, Duprat F, Ehrengruber MU, Lazdunski M and Patel AJ (2003) K+-dependent cerebellar granule neuron apoptosis. Role of TASK leak K+ channels. Journal of Biological Chemistry 278:32068-32076 11. Chemin J, Girard C, Duprat F, Lesage F, Romey G and Lazdunski M (2003) Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels. EMBO Journal 22:5403-5411 12. Borg JJ, Hancox JC, Hogg DS, James AF and Kozlowski RZ (2004) Actions of the anti- oestrogen agent clomiphene on outward K+ currents in rat ventricular myocytes. Clinical and Experimental Pharmacology and Physiology 31:86-95 13. Wulff T, Hougaard C, Klaerke DA and Hoffmann EK (2004) Co-expression of mCysLT<sub>1</sub> receptors and IK channels in Xenopus laevis oocytes elicits LTD<sub>4</sub>-stimulated IK current, independent of an increase in [Ca2+]<sub>i</sub>. Biochimica et Biophysica Acta - Biomembranes 1660:75-79 14. Patel AJ and Lazdunski M (2004) The 2P-domain K+ channels: Role in apoptosis and tumorigenesis. Pflugers Archiv European Journal of Physiology 448:261-273 15. Cotten JF, Zou HL, Liu C, Au JD and Yost CS (2004) Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2). Molecular Brain Research 128:112-120 16. Holter J, Carter D, Leresche N, Crunelli V and Vincent P (2005) A TASK3 channel (KCNK9) mutation in a genetic model of absence epilepsy. Journal of Molecular Neuroscience 25:37-51 Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM 17. Chemin J, Patel AJ, Duprat F, Lauritzen I, Lazdunski M and Honor+¬ E (2005) A phospholipid sensor controls mechanogating of the K+ channel TREK-1. EMBO Journal 24:44-53 18. Larkman PM and Perkins EM (2005) A TASK-like pH- and amine-sensitive 'leak' K+ conductance regulates neonatal rat facial motoneuron excitability in vitro. European Journal of Neuroscience 21:679-691 19. Roh+ícs T, Lopes CMB, Michailidis I and Logothetis DE (2005) PI(4,5)P<sub>2</sub> regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nature Neuroscience 8: 626-634 20. Roper P (2005) Frequency-dependent depletion of secretory vesicle pools modulates bursting in vasopressin neurones of the rat supraoptic nucleus. Neurocomputing 65-66:485-491 21. Suh BC and Hille B (2005) Regulation of ion channels by phosphatidylinositol 4,5- bisphosphate. Current Opinion in Neurobiology 15:370-378 22. Kim D (2005) Physiology and pharmacology of two-pore domain potassium channels. Current Pharmaceutical Design 11:2717-2736 23. Besana A, Robinson RB and Feinmark SJ (2005) Lipids and two-pore domain K+ channels in excitable cells. Prostaglandins and Other Lipid Mediators 77:103-110 24. Chen X, Talley EM, Patel N, Gomis A, McIntire WE, Dong B, Viana F, Garrison JC and Bayliss DA (2006) Inhibition of a background potassium channel by Gq protein +¦-subunits. Proceedings of the National Academy of Sciences of the United States of America 103:3422-3427 25. Clark MA and Lambert NA (2006) Endogenous regulator of G-protein signaling proteins regulate the kinetics of G+¦<sub>q/11</sub>-mediated modulation of ion channels in central nervous system neurons. Molecular Pharmacology 69:1280-1287 26. Meuth SG, Aller MI, Munsch T, Schuhmacher T, Seidenbecher T, Meuth P, Kleinschnitz C, Pape HC, Wiendl H, Wisden W and Budde T (2006) The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons. Molecular Pharmacology 69:1468-1476 27. Holt AG, Asako M, Keith Duncan R, Lomax CA, Juiz JM and Altschuler RA (2006) Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus. Hearing Research 216-217:146-153 28. Kang D and Kim D (2006) TREK-2 (K<sub>2P</sub>10.1) and TRESK (K<sub>2P</sub>18.1) are major background K+ channels in dorsal root ganglion neurons. American Journal of Physiology - Cell Physiology 291: 29. Zanzouri M, Lauritzen I, Duprat F, Mazzuca M, Lesage F, Lazdunski M and Patel A (2006) Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway. Journal of Biological Chemistry 281:28910-28918 30. Fujiwara Y and Kubo Y (2006) Regulation of the desensitization and ion selectivity of ATP- gated P2X<sub>2</sub> channels by phosphoinositides. Journal of Physiology 576:135-149 31. Zanzouri M, Lauritzen I, Lazdunski M and Patel A (2006) The background K+ channel TASK-3 is regulated at both the transcriptional and post-transcriptional levels. Biochemical and Biophysical Research Communications 348:1350-1357 32. Kang D, Han J and Kim D (2006) Mechanism of inhibition of TREK-2 (K<sub>2P</sub>10.1) by the G <sub>q</sub>-coupled M<sub>3</sub> muscarinic receptor. American Journal of Physiology - Cell Physiology 291: 33. Mathie A (2007) Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors. Journal of Physiology 578:377-385 Dr. Petheő Gábor OTKA pályázatokhoz csatolandó közleményjegyzéke, Created on 2/24/2011 12:00 PM 34. Lotshaw DP (2007) Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels. Cell Biochemistry and Biophysics 47:209-256 35. Chemin J, Patel AJ, Delmas P, Sachs F, Lazdunski M and Honore E (2007) Regulation of the Mechano-Gated K<sub>2P</sub> Channel TREK-1 by Membrane Phospholipids. Current Topics in Membranes 59:155-170 36. Veale EL, Kennard LE, Sutton GL, MacKenzie G, Sandu C and Mathie A (2007) G+¦<sub>q</sub>-mediated regulation of TASK3 two-pore domain potassium channels: The role of protein kinase C. Molecular Pharmacology 71:1666-1675 37. Putzke C, Wemh+¦ner K, Sachse FB, Rinn+¬ S, Schlichth+¦rl G, Li XT, Ja+¬ L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-M++ller R et al (2007) The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovascular Research 75:59-68 38. Shirahata M, Balbir A, Otsubo T and Fitzgerald RS (2007) Role of acetylcholine in neurotransmission of the carotid body. Respiratory Physiology and Neurobiology 157:93-105 39. Yuill KH, Stansfeld PJ, Ashmole I, Sutcliffe MJ and Stanfield PR (2007) The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1: Contributions of the pore domains. Pflugers Archiv European Journal of Physiology 455:333-348 40. Duprat F, Lauritzen I, Patel A and Honor+¬ E (2007) The TASK background K<sub>2P</sub> channels: chemo- and nutrient sensors. Trends in Neurosciences 30:573-580 41. Thyagarajan B, Lukacs V and Rohacs T (2008) Hydrolysis of phosphatidylinositol 4,5- bisphosphate mediates calcium-induced inactivation of TRPV6 channels. Journal of Biological Chemistry 283:14980-14987 42. Doroshenko P and Renaud LP (2009) Acid-sensitive TASK-like K+ conductances contribute to resting membrane potential and to orexin-induced membrane depolarization in rat thalamic paraventricular nucleus neurons. Neuroscience 158:1560-1570 43. Matavel A and Lopes CMB (2009) PKC activation and PIP<sub>2</sub> depletion underlie biphasic regulation of IKs by Gq-coupled receptors. Journal of Molecular and Cellular Cardiology 46:704-712 44. Tang B, Li Y, Nagaraj C, Morty RE, Gabor S, Stacher E, Voswinckel R, Weissmann N, Leithner K, Olschewski H and Olschewski A (2009) Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology 41:476-483 45. Thompson CM, Troche K, Jordan HL, Barr BL and Wyatt CN (2010) Evidence for functional, inhibitory, histamine H3 receptors in rat carotid body Type I cells. Neuroscience Letters 471:15-19 46. Koizumi H, Smerin SE, Yamanishi T, Moorjani BR, Zhang R and Smith JC (2010) TASK channels contribute to the K+-dominated leak current regulating respiratory rhythm generation in vitro. Journal of Neuroscience 30:4273-4284 47. Ortiz FC and Varas R (2010) Muscarinic modulation of TASK-like background potassium channel in rat carotid body chemoreceptor cells. Brain Research 1323:74-83 48. 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Washout Periods for Brimonidine for latanoprost ( n ؍ 17) was 4.4 ؎ 3.2 weeks ( P ؍ .24). 0.2% and Latanoprost 0.005% In all but one patient, brimonidine returned to baseline by 5 weeks and latanoprost returned by 8 weeks. William C. Stewart, MD, Keri T. Holmes, and CONCLUSION: After discontinuing latanoprost or bri- Mark A. Johnson monidine, a wide variation exist

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3/2. Multiple Choice The following questions have one or more correct answers. Use the notations given below: A: only the 1st , 2nd and 3th are correct B: only the 1st and 3th are correct C: only the 2nd and 4th answers are correct D: only the 4th answers is correct E: all of the answers are correct 131. Choose the compounds whose UV spectra display a significant shift u

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