SIGMA-ALDRICH Material Safety Data Sheet Date Printed: 15/DEC/2004 Date Updated: 14/MAR/2004 Version 1.2 According to 91/155/EEC 1 - Product and Company Information Product Name TETRACYCLINE Product Number 87128 Company Sigma-Aldrich Pte Ltd #08-01 Citilink Warehouse Singapore 118529 Singapore Technical Phone # 65 271 1089 Fax 65 271 1571 2 - Composition/Information on Ingredients Product Name CAS # EC no Annex I Index Number TETRACYCLINE FREE BASE 60-54-8 200-481-9 None Formula C22H24N2O8 Molecular Weight 444.44 AMU Synonyms Abramycin * Abricycline * Achromycin (naphthracene derivatives) * Agromicina * Ambramicina * Ambramycin * Amycin * Biocycline * Cefracycline suspension * Criseociclina * Cyclomycin * Cytome * Deschlorobiomycin * Hostacyclin * Liquamycin * Medocycline * 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide * Micycline * Neocycline * Oletetrin * Omegamycin * Orlycycline * Panmycin * Polycycline (antibiotic) * Resteclin * Roviciclina * Sumycin syrup * Tetrabon * Tetra-Co * Tetracycline * Tetracycline I * Tetracycline II * Tetracyn * Tetradecin * Tetrafil * Tsiklomitsin * T-125 * Veracin * Vetacyclinum 3 - Hazards Identification SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT Harmful if swallowed.
4 - First Aid Measures AFTER INHALATION If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
AFTER INGESTION If swallowed, wash out mouth with water provided person is conscious. Call a physician.
5 - Fire Fighting Measures EXTINGUISHING MEDIA Suitable: Noncombustible. Use extinguishing media appropriate to surrounding fire conditions.
SPECIAL RISKS Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
6 - Accidental Release Measures PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
7 - Handling and Storage HANDLING Directions for Safe Handling: Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE Conditions of Storage: Keep tightly closed.
Store at 2-8°C SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties FLUKA - 87128 www.sigma-aldrich.com Page 2
Appearance Color: Yellow Form: Powder Property Value At Temperature or Pressure pH N/A BP/BP Range N/A MP/MP Range 172 °C Flash Point N/A Flammability N/A Autoignition Temp N/A Oxidizing Properties N/A Explosive Properties N/A Explosion Limits N/A Vapor Pressure N/A SG/Density N/A Partition Coefficient N/A Viscosity N/A Vapor Density N/A Saturated Vapor Conc. N/A Evaporation Rate N/A Bulk Density N/A Decomposition Temp. N/A Solvent Content N/A Water Content 4 - 11 % Surface Tension N/A Conductivity N/A Miscellaneous Data N/A Solubility N/A 10 - Stability and Reactivity STABILITY Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides.
HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur 11 - Toxicological Information RTECS NUMBER: QI8750000 ACUTE TOXICITY LDLO Multiple Woman 310 MG/KG Remarks: Gastrointestinal:Nausea or vomiting. Liver:Jaundice, other or unclassified. Nutritional and Gross Metabolic:Changes in:Metabolic acidosis.
LD50 Oral Rat FLUKA - 87128 www.sigma-aldrich.com Page 3
807 mg/kg LD50 Intraperitoneal Rat 310 MG/KG LD50 Intravenous Rat 129 MG/KG LD50 Oral Mouse 678 mg/kg LD50 Intraperitoneal Mouse 120 MG/KG LD50 Subcutaneous Mouse 400 MG/KG LD50 Intravenous Mouse 157 MG/KG LD50 Oral Guinea pig 1875 mg/kg SENSITIZATION Sensitization: Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.
Skin: Can cause skin photosensitization.
SIGNS AND SYMPTOMS OF EXPOSURE Can cause phototoxic reactions, gastrointestinal disturbances, turn teeth yellow and reduce mineralization.
ROUTE OF EXPOSURE Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION Liver. Teeth. Bones.
CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is probably not carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.
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CHRONIC EXPOSURE - MUTAGEN Mouse 110 MG/KG Intraperitoneal 24H Micronucleus test S. typhimurium ZNEG Histidine reversion (Ames) CHRONIC EXPOSURE - TERATOGEN Result: Possible risk of congenital malformation in the fetus.
Species: Rat Dose: 100 UG/M3/24H Route of Application: Inhalation Exposure Time: (1-20D PREG) Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat Dose: 1 MG/M3/24H Route of Application: Inhalation Exposure Time: (1-20D PREG) Result: Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord).
Species: Rat Dose: 3 GM/KG Route of Application: Unreported Exposure Time: (9-14D PREG) Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse Dose: 700 MG/KG Route of Application: Oral Exposure Time: (14D POST) Result: Specific Developmental Abnormalities: Skin and skin appendages.
Species: Mammal Dose: 55 MG/KG Route of Application: Intravenous Exposure Time: (8-18D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Species: Woman Dose: 200 MG/KG Route of Application: Unreported Exposure Time: (34-35W PREG) Result: Effects on Newborn: Delayed effects.
Species: Woman Dose: 80 MG/KG Route of Application: Unreported Exposure Time: (1-39W PREG) Result: Effects on Newborn: Other postnatal measures or effects.
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Species: Rat Dose: 10 GM/KG Route of Application: Oral Exposure Time: (8-21D PREG/7D POST) Result: Effects on Newborn: Behavioral.
Species: Rat Dose: 863 MG/KG Route of Application: Oral Exposure Time: (4D POST) Result: Effects on Newborn: Behavioral. Effects on Newborn: Physical.
Species: Rat Dose: 413 MG/KG Route of Application: Oral Exposure Time: (3D POST) Result: Effects on Newborn: Behavioral. Effects on Newborn: Physical.
Species: Rat Dose: 700 MG/KG Route of Application: Intramuscular Exposure Time: (8-14D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
12 - Ecological Information No data available.
13 - Disposal Considerations SUBSTANCE DISPOSAL Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.
14 - Transport Information RID/ADR Non-hazardous for road transport.
IMDG Non-hazardous for sea transport.
IATA Non-hazardous for air transport.
15 - Regulatory Information CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES INDICATION OF DANGER: Xn Harmful.
R-PHRASES: 22 Harmful if swallowed.
S-PHRASES: 22 36 Do not breathe dust. Wear suitable protective clothing.
16 - Other Information FLUKA - 87128 www.sigma-aldrich.com Page 6
WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
DISCLAIMER For R&D use only. Not for drug, household or other uses.
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