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Interceptor PI • NOV0407-02 2004-07-07 11:26 AM Page 1 Josiane 04-07:NOV0407-02 Interceptor PI: Administration
Safety studies were conducted in young cats and kittens begin- INTERCEPTOR Flavor Tabs are highly palatable and may be ning at two weeks of age. Doses of 1X, 3X and 5X demonstrat- Indications
given by hand. They may also be added to dog food or admini- ed no drug-related effects. Tolerability studies at exaggerated INTERCEPTOR Flavor Tabs are recommended for the doses of 10X also demonstrated no drug-related adverse prevention of heartworm disease caused by Dirofilaria
effects in kittens and young adult cats.
Flavor TabsTM
The tablet(s) should be placed into the dog’s mouth on the back immitis and for the treatment and control of parasitic
of the tongue, or can be hidden in food. The dog should be infections due to adult hookworm (Ancylostoma tubaeform)
Heartworm Disease in Cats
watched closely for several minutes following administration of and adult roundworm (Toxocara cati) in cats two weeks of age
Much of the damage due to heartworm disease in cats occurs the INTERCEPTOR Flavor Tab to ensure that the entire dose has before there are any outward signs of the disease, and these been swallowed. If it is suspected that any of the dose has been signs may be quite variable. Prevention of the disease is impor- Safety Studies
Available in four sizes for convenient dosing of cats of various The disease is caused by Dirofilaria immitis which lives in the INTERCEPTOR has been tested and found to have no adverse right side of the heart and adjacent blood vessels. A cat not on reactions in over 75 dog breeds, pregnant females, breeding preventive medication can be infected with several worms. The Ingredient/
adult worms cause disease by damaging blood vessels in the Indications
males and females, and puppies greater than 2 weeks of ageand one (1) kilogram body weight when administered at the Cat Weight
lungs which obstructs normal blood flow. This can result in an INTERCEPTOR® Flavor Tabs™ are recommended for the increased workload on the heart which can cause heart failure.
prevention of heartworm disease caused by Dirofilaria
The adult worms can also migrate into other tissues of the cen- Five pivotal target animal studies provided evidence that milbe-
immitis and for the treatment and control of parasitic
tral nervous system such as the brain.
mycin oxime can be used safely in dogs. Milbemycin was infections due to adult hookworm (Ancylostoma caninum),
administered daily to reproducing dogs, prior to mating and The disease is spread from animal to animal by any one of over adult roundworms (Toxocara canis and Toxascaris leonina),
during gestation, without detectable adverse effects.
70 species of mosquitoes. Female adult heartworms discharge and adult whipworm (Trichuris vulpis) in dogs two weeks of
The minimum dosage level is 2 mg/kg of body weight. Cats larval forms (microfilariae) into the bloodstream of a cat. The In a chronic study (10 months) milbemycin was given to dogs weighing over 11.5 kg should receive the appropriate combina- mosquito becomes infected by sucking up these microfilariae at rates up to 5X the monthly use rate, on three consecutive as it takes a blood meal from an infected cat; during the next days. The only adverse effects found were transient ataxia and For heartworm prevention, administer INTERCEPTOR Flavor
two to three weeks these microfilariae grow and molt twice Available in four sizes for convenient dosing of dogs of various trembling in some 8-week old puppies. An additional study in Tabs once per month on the same day.
inside the mosquito to reach the infective larval stage which 8-week old puppies demonstrated no adverse effects when Reminder stickers are provided for use on a calendar.
enters another cat as the mosquito feeds again. In the cat, it milbemycin was given for 3 days at the proposed rate and only The initial dose must be given within a month after the first indi- takes about seven to eight months for these larvae to grow, minor effects in a few animals at the 5X rate given daily for Ingredient/
cation of mosquito activity and regular dosing should continue move to the heart, mate and start the cycle again.
Dog Weight
until at least one month after the end of the mosquito season.
Two specifically designed target animal safety studies in pup- If the interval between doses exceeds 30 days, the efficacy of pies 2 weeks of age were conducted. These studies demon- INTERCEPTOR may be reduced. If regular monthly treatment is This product has not been tested in breeding cats, in pregnant strated a very adequate margin of safety for the use of milbe- delayed, it is essential to immediately recommence treatment at queens or in heartworm positive cats.
mycin in young puppies between 2 and 8 weeks of age.
the recommended dosage rate. If treatment has been delayed Testing: Despite the fact that the sensitivity of the heartworm Seven supportive animal safety studies provided evidence that
beyond two months, the advice of a veterinarian should be antigen tests is relatively low in cats, it is still considered good The minimum dosage level is 0.5 mg/kg of body weight. Dogs milbemycin oxime would not be expected to have adverse medical practice to test before administering chemoprophylax- weighing over 45 kg should receive the appropriate combina- effects in dogs under normal use conditions and up to 3X the is for the first time, if at least 8 months have passed since there For hookworm and roundworm, control will be obtained in
conjunction with heartworm prevention, or by separate was an opportunity for infection. The cat should be examined For heartworm prevention, administer INTERCEPTOR Flavor
administration of INTERCEPTOR Flavor Tabs. Kittens should by a veterinarian prior to starting heartworm prevention med- Tabs once per month on the same day.
be treated every 2 weeks from 3 weeks of age to 3 months of Reminder stickers are provided for use on a calendar.
Prior to initiation of INTERCEPTOR Flavor Tab treatment for the age, then monthly until 6 months of age. In non-heartworm first time, dogs 6 months of age or older should be tested for The initial dose must be given within a month after the first indi- endemic areas, adult cats should be treated a minimum of 4 existing heartworm infections. Dogs on preventive medication cation of mosquito activity and regular dosing should continue times per year, or as directed by the veterinarian.
should be retested at the start of the following season.
until at least one month after the end of the mosquito season.
Thereafter, testing is performed at the veterinarian’s discretion.
If the interval between doses exceeds 30 days, the efficacy of Administration
If positive, dogs should be converted to negative status by the INTERCEPTOR may be reduced. If regular monthly treatment is INTERCEPTOR Flavor Tabs are highly palatable and may be use of appropriate heartworm adulticides prior to INTERCEP- delayed, it is essential to immediately recommence treatment at given by hand. They may also be added to cat food or adminis- Presentation
the recommended dosage rate. If treatment has been delayed beyond two months, the advice of a veterinarian should be When milbemycin was administered to heartworm-infected The tablet(s) should be placed into the cat’s mouth on the back four Flavor Tab sizes, formulated and package colour coded sought. When replacing an existing diethylcarbamazine citrate dogs, a relatively mild shock-like reaction was observed, prob- of the tongue, or can be hidden in food. The cat should be according to the weight range of the cat.
(DEC) or ivermectin based product, the initial dose of INTER- ably due to the microfilaricidal effect of milbemycin.
watched closely for several minutes following administration of Available in the following package size: 6 INTERCEPTOR Flavor CEPTOR may be given at any time within 30 days of the last the Flavor Tab to ensure that the entire dose has been Tabs packaged 10 per display carton.
swallowed. If it is suspected that any of the dose has been lost, Keep out of reach of children. If accidentally swallowed, call For hookworm, roundworm and whipworm, control will
Storage Conditions
be obtained in conjunction with heartworm prevention, INTERCEPTOR Flavor Tabs should be stored at room tempera- or by separate administration of INTERCEPTOR Flavor Tabs.
Presentation
Safety Studies
INTERCEPTOR should be given to puppies at 2, 4, 6, 8, 10 and INTERCEPTOR Flavor Tabs (milbemycin oxime) has been test- INTERCEPTOR is available in four Flavor Tab sizes, formulated 12 weeks of age, then monthly to 6 months of age. In non- ed safely in over 8 different breeds of cats and kittens, two and package colour coded according to the weight range of heartworm endemic areas, adult dogs should be treated a weeks of age or greater. In clinical field studies, 310 cats com- minimum of 4 times per year, or as directed by the veterinarian.
pleted treatment with milbemycin oxime. Milbemycin oxime Available in the following package size: 6 INTERCEPTOR Flavor was used safely in animals receiving frequently used veterinary Tabs packaged 10 per display carton.
products such as vaccines, anthelmintics, anesthetics, antibi- ® Registered Trademark of Novartis Animal Health Canada Inc.
TM Trademark of Novartis Animal Health Canada Inc.
otics, steroids, flea collars, shampoos and dips.

Source: http://www.ah.novartis.ca/downloads/companion/interceptor_monograph_cats.pdf

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