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Significance of sutherlandia

TERRA TREATMENT - the treatment you can trust! The Significance of Sutherlandia - PRO
Sutherlandia has application in the treatment of all conditions that are associated with
impaired immune function, stress or general debility of the body. It strengthens the body's
natural immune response, supports the healing system and accelerates the recovery process.
The full botanical name of Sutherlandia is Sutherlandia frutescens subspecies microphylla
elite SU1™ chemotype. It has been commonly referred to as: Kankerbossie (Afrikaans) and
Cancer Bush (English).
Another traditional name is ‘Phetola’ which means ‘it changes’ - meaning that the plant
changes the course of many illnesses towards a favourable outcome. (This is similar to the
European concept of an alterative.)
Sutherlandia enjoys a long history as a highly valued component of African Traditional
Medicine for:
-Colds and flu
-Asthma and bronchitis
-Mild to moderate hypertension
-Digestive disorders, peptic ulcers, gastritis and reflux oesophagitis
-Hot flushes and irritability in menopause
-Type 2 diabetes
-Viral hepatitis
-General immune system support and longevity
Sutherlandia frutescens is regarded as the most significant and multi-purpose of the medicinal
plants in Southern Africa. It powerfully assists the body to mobilize its own resources
(the immune system) to cope with physical and mental stresses, and is therefore, correctly
speaking, an adaptogen (in the class of herbs such as Astragalus, Ginseng, and Ashwagandha)
and has even been referred to as ‘African Ginseng’.
In fact, Sutherlandia is considered the African adaptogen par excellence. It is an herb with a
profound effect on the body-mind-energy system, maintaining and optimizing physical,
mental and emotional wellness, and it is as if Nature has combined, in a single plant, the
immune stimulating benefits of Echinacea, the adapatogenic effects of Panax Ginseng and the
energy of Ashwagandha.
The Sutherlandia PRO formulation is a product that has been carefully designed to strengthen
and support the immune system thereby enhancing the body’s ability to ward off illness and
mitigate the effects of stress, be it mental or physiological.
Each capsule of Sutherlandia – PRO formulation (including co-factors) contains:
*Sutherlandia frutescens microphylla (elite SU1™ chemotype)
*L-Arginine (free base)
*Vitamin B6 (from Pyridoxine hydrochloride)
*Zinc (from Zinc L-monomethionine)
*Selenium (from Se-methylseleno-L-cysteine)
Terra Treatment BV, Tel: +31 (0) 346 266263 The Netherlands TERRA TREATMENT - the treatment you can trust! Chemistry and Pharmacology

Terra Treatment sells three orally taken products that contain Sutherlandia frutescens.
They are our pure Sutherlandia frutescens tablets 300 mg, the vegi-capsuled Sutherlandia 400
mg, also known as African Ginseng™, and our new product, the Adaptogenic Immuno-
modulator Sutherlandia - PRO formulation, a combination of products whose key ingredient is
Sutherlandia frutescens.
The Sutherlandia-PRO Formulation contains:

*Sutherlandia frutescens SU1 Chemotype
The second ingredient, L-Arginine, is an amino acid present in the proteins of all life forms. It
is classified as a semi-essential, or conditionally essential, amino acid. This means that under
normal circumstances the body can synthesize sufficient L-Arginine to meet physiological
demands. However, there are conditions, such as prolonged exposure to a highly stressful
environment (whether physiological or mental), where the body cannot keep up. These put an
increased demand on the body for the synthesis of L-Arginine. Specifically, Arginine is
important in the formation of polyamines, molecules that newly formed B cells and T cells
require during their rapid growth and proliferation in the early stages of an infection. Arginine
also promotes wound healing and regeneration of the liver. The form of Arginine used in this
formulation is L-Arginine (L is the natural form), free form and freebase for high bio-
availability and rapid absorption into the bloodstream.
*Vitamin B6
The third ingredient, Vitamin B6, is pyridoxine hydrochloride, which is both stable and bio
available. Pyridoxine or Vitamin B6 is a water-soluble B-complex vitamin necessary for the
proper function of over 70 different enzymes that participate in amino acid metabolism.
Pyridoxine also aids in maintaining sodium and potassium balance. It is required by the
nervous system, and is needed for normal brain function and for the synthesis of the nucleic
acids RNA and DNA, which contain the genetic instructions for the reproduction of all cells
and for normal cellular growth. It activates many enzymes and aids in the absorption of
vitamin B12, supports immune system function, and is necessary for antibody production.
The forth ingredient, Selenium, is in the form: Se-methylseleno-L-cysteine (SeSMC, patent
pending). SeSMC or Methylselenocysteine is a seleno-amino-acid that is synthesized by
vegetables such as garlic and broccoli. It is a newly developed, bio-available and safe form of
the essential trace mineral nutrient, Selenium. Selenium in the form of Selenocysteine is an
essential component of antioxidant enzymes such as glutathione peroxidase and is also found
in several proteins in the body.
The immunological role of Selenium is well documented. Additionally, adequate Selenium
nutrition offers a line of defence against viral infections and chronic diseases as well.
Methylselenocysteine, in light of its high bioavailability and natural occurrence in food
sources, is the most efficacious Selenium supplement available.
Terra Treatment BV, Tel: +31 (0) 346 266263 The Netherlands TERRA TREATMENT - the treatment you can trust!
The fifth ingredient is Zinc. This is in the form of Zinc L-monomethionine (U.S. Patent Nos.
4,764,633 and 5,278,329). This is the most bio available form of Zinc currently available.
In a high proportion of studies, including those involving the entire range of essential
micronutrients, both vitamins and minerals, Zinc continues to show the most specific and, in
many ways, one of the strongest effects on the functioning of the immune system of any
micronutrient. Zinc has a unique role in thymus dependent T-cell mediated immune response.
Zinc's immunomodulatory effects may be accounted for by its membrane-stabilization effect,
which affects signalling processes involved, in cell-mediated immunity. Another role of zinc
is in the maintenance of the integrity of biological membranes resulting in their protection
against oxidative injury. Zinc has immunomodulatory activity and antioxidant activity. Zinc
also has putative, antiviral, fertility-enhancing and retinoprotective properties.
Clinical and Supplement Uses:
Preliminary scientific research, published peer-reviewed scientific research, and clinical
experience suggests that the key phytochemicals in select chemotypes of Sutherlandia
varieties are:
-Anti-viral, anti-fungal and anti-bacterial
-Inhibitors of Tumor Necrosis Factor (TNF) - excess production of TNF known to drive the
wasting process in Cancer and TB patients.

2 Capsules per day. Sutherlandia-PRO can be used in conjunction with both Shilajit and
Sceletium-PRO, together they form our Health Trilogy.
Side Effects

In keeping with World Health Organization guidelines for the assessment of herbal medicines,
Sutherlandia is generally regarded as safe on the basis of its long history of safe use in South
It is one of the few medicinal plants on the world market that has been formally studied for
safety, in this case, in Vervet monkeys. The Medical Research Council of South Africa tested
elite chemotype Sutherlandia dried leaf powder for safety in 2001. The study was part of a
Medical Research Council Indigenous Knowledge Systems (IKS) process to establish a
"clinical platform" to assess the safety and efficacy of promising South African indigenous
medicinal plants.
No toxicity was apparent in any variable studied by the MRC.
Terra Treatment BV, Tel: +31 (0) 346 266263 The Netherlands TERRA TREATMENT - the treatment you can trust!

None documented at this time. It is not recommended for pregnant and breastfeeding women,
since the safety study did not include these situations.
Raw Materials: SU1 chemotype

In the interests of consistent product quality, and to prevent environmental damage, we use
only certified organically cultivated plant material that has been selected from natural strains
of plants with a typical and reproducible phytochemical profile.
An elite chemotype (called SU1™) of Sutherlandia frutescens (based specifically on the
Microphylla subspecies) has been developed, where specific phytochemical compounds (with
particular reference to the triterpenoid glucoside, SU1), and including amino acids, are
assayed and quantified and it is the seeds of this chemotype that are re-sown for our
Sutherlandia products.
This chemotype has been developed to ensure that batches of Sutherlandia are of reproducible
quality, and so that research, such as safety studies, can be reliably applied to the actual
product being sold.
Sutherlandia frutescens subspecies microphylla elite (SU1™) chemotype is also the form of
Sutherlandia that was used in the Medical Research Council Safety Study.
As you can see from the summaries of each of the 5 components that make up the
Sutherlandia PRO- formulation, the components chosen all have similar, related,
complementary and synergistic effects in the body-mind-emotional-energy system.
We believe that this formulation will be significantly more effective than the sum of its parts
and will be a premium and highly efficacious supplement to use as a general adaptogen and
immune strengthener in healthy people and as a very useful, safe and effective nutritional
remedy for those challenged by diseases such as Cancer, TB and Chronic Fatigue Syndrome.
The effects of Sutherlandia are particularly profound and subjectively noticeable, and with the
support of the other 4 nutritional co-factors, this product will also be a highly effective
Quality of Life and overall Wellness supplement.
Terra Treatment BV, Tel: +31 (0) 346 266263 The Netherlands


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Original Research Received: August 11, 2005 Accepted after revision: March 15, 2006 Enhanced External Counterpulsation Reduces Lung/Heart Ratio at Stress in Patients with Coronary Artery Disease Chii-Ming Lee a Yen-Wen Wu a Hsiang-Yiang Jui a Ming-Fong Chen a a National Taiwan University Hospital, Taipei , Taiwan; b University of Pittsburgh, Pittsburgh, Pa. , USA Key Words

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